Conserved Protein Domain Family
Glucan_BSP_ModH

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cd04191: Glucan_BSP_ModH 
Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan.
Periplasmic Glucan Biosynthesis protein ModH is a glucosyltransferase that catalyzes the elongation of beta-1,2 polyglucose chains of glucan, requiring a beta-glucoside as a primer and UDP-glucose as a substrate. Glucans are composed of 5 to 10 units of glucose forming a highly branched structure, where beta-1,2-linked glucose constitutes a linear backbone to which branches are attached by beta-1,6 linkages. In Escherichia coli, glucans are located in the periplasmic space, functioning as regulator of osmolarity. It is synthesized at a maximum when cells are grown in a medium with low osmolarity. It has been shown to span the cytoplasmic membrane.
Statistics
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PSSM-Id: 133034
View PSSM: cd04191
Aligned: 17 rows
Threshold Bit Score: 381.626
Threshold Setting Gi: 126734550
Created: 17-Jul-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Ligand bindingDXD motif
Feature 1:Ligand binding site
Evidence:
  • Comment:Predicted ligand binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             # #                                                                        
gi 91787013  160 TAIIMPICNEDVRTVFAGLRATCESVAmtgh-vknfDVFVLSDSSHPAIIRaeraawedlrsqlashpeqpqievYYRLR 238
gi 146329303 119 CAIVMPVYGEDPAMTGAALLAIADDLKnsai-aarcELFILSDTQNVDAWLketaafsll-------rarcalplWYRRR 190
gi 189036520 134 TAILMPTYNESPDRVFSAVSVMAETLSqtgh-ghafDWFILSDTTDPDIALleeqaflvlr-----qethkhsrvYYRRR 207
gi 114562481 129 TAVLLPIYNEDPLRIRATIEAMSADLIatap--gkyAFFILSDTNRADAWIaeeqtfldli-----nnsqpqcpvYYRRR 201
gi 33301413  145 TAILMPVYNEDAAAVFARLRAMDASIAetgs-arnfDIFVISDTRDAQVALaeqacfarf-------rreancnvYYRIR 216
gi 90419818  166 TAIVMTLRNEAPEPSFERLEAMRRSLAktgl-adhfRFFILSDTDDAEIGQreeaafegft-----aifapghepVYRRR 239
gi 32444759   89 TAVLVPVYNESPIDVFARVEAMVRSLGpdq----rfDFFVLSDTNDSEVWLaeelawsqlmdr-leeqvstscnvYYRHR 163
gi 69938827  148 IAVVMPVYHEDAAATTGLLAALARDLYrvgl-adraEIFVLSDSREPRAVFeemaaisrl-------rdispvpvWYRRR 219
gi 46206064   95 TAAVVAIHAEDPIAVFSAIRVMARSLQreggdgsdiDIFVLSDTREGAISAveeheftriqaw-arregrgmpriRYRRR 173
gi 126734550  85 TAVLVALCGEDAGPLAAYLNHFTRGLGavgl-gsetTVFVLSDTSAAPQIAaeeaalad---------liaqgriVYRRR 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                                                 
gi 91787013  239 KRRTDRKAGNVADFCRRWGKdyRYMVVLDADSvmsgdclvamvklMEANPKAGIIQTATQAIGHVTLHARAQQFASRVTG 318
gi 146329303 191 SKNIGRKAGNIEQFIKTWGGryAYFLLLDADSlmsaetivkmvarMDADPNLALLQTQPRLLGAESLLARTIQFAGGLYG 270
gi 189036520 208 RKNVARKAGNVADFCRRWGSryDHLLVLDADSlmesstitglaqrMQADPDAGLIQTIPSLINGTTLMARLQQFAARIYG 287
gi 114562481 202 HQNSERKAGNIGDWVQRWGGdyEAMIVLDADSimsaksmvtlsrrLAGAPGVGLIQTLPTLVFANTLYSRLQQFANQCFG 281
gi 33301413  217 KENTGRKAGNVADWVSRWGSayEHMLVLDADSlmtgeamvrladaMERHPGAGLIQTMPMIINGQTIFARTLQFATRLYG 296
gi 90419818  240 RDNAGYKAGNIAAFLADEGAayDYFLPLDSDSvmagdvivrmvaaMERHPRLGILQSLVVGMPANSGFARIFQFGMRHGM 319
gi 32444759  164 RENVARKAGNIADFCRRWSDpyPFMIVLDADSllepdtmiemvrrMRADDRLGILQVPPTPIGRQSWFARMQQFAAAAYG 243
gi 69938827  220 SSNKGRKAGNVGEFVRRWGGryDQMVVLDADSvvgaatirtlsarMNADPAIGLIQTMPMLVGGQTIFARLTQFAGRIYG 299
gi 46206064  174 TENTGRKAGNIAEFCETYGPeyDFMIVLDADSlmtgaamrrlarlMEENPRLGLIQTVSYAAGRDTLFARIQQFAVRLYA 253
gi 126734550 155 VENTNKKPGNIADWLDSHGSdfDYMVVKDADSrmtpdsikqliwqLESRPDTGLLQAAIALIPGRTRFGRHQRISSRLLG 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 91787013  319 RLFTLGMQFWQMGESHYWGHNAIIRIAPFMQHCALAhIKGTGGMAGSIMSHDFVEAALMRRAGfhvwlvadlVGSYEQQP 398
gi 146329303 271 KIVGRGISAWQGYEGNYWGHNALIRTQAFAESCGLPvLKGRRPIGGHIMSHDFVEAALLCRRGwqvrmdsdlNGSYEGLP 350
gi 189036520 288 PVIGTGLGWWVQKEGNFWGHNAIIRTEAFMTAAGLPnLKGKPPFGGHIMSHDFVEAALIRRAGwsvviaydlPGSYEECP 367
gi 114562481 282 PIYAEGLSAWHGLSSNFWGHNAIIRTKAFAESCHLPiLSGKAPFGGHVLSHDFIEAALLRRAGwgvrfdtdiEASFEEAP 361
gi 33301413  297 RVAWTGLAWWSGSESSFWGHNAIVRTRAFAETCGLPhLPGPKPFGGEVMSHDALESALLRRGGwsvhlapylDGSYEESP 376
gi 90419818  320 RSFTMGAAWWNADCGPYWGHNAVIRTAAFRAHCKLPnLPGRPPLGGPVLSHDQLEAAYMRRAGyevrvipveTRSYETNP 399
gi 32444759  244 PVFCEGFDAWAAEQGNYWGHNAIIRVEAFCDCCDLPvLPGQAPLGGEILSHDFVEASLLVRRGwkvrlandlGGSYEECP 323
gi 69938827  300 PAVARGVAAWSGDSGNFWGHNAIIRVEAFAQCCGLPeLPGKPPFGGTILSHDFVEAALLRRAGwkvrldhdlRQSFEGCP 379
gi 46206064  254 PLSLRCLETWQGPDGSYWGHNAILRVEAFANNAELPvLSGKPPLGGEILCHDIGEGALLRRAGwevrllpemGGTWEEMP 333
gi 126734550 235 PAFGRGFAAWSGKAGNYWGHNAIMRVAAFRSAAALPrLSGQAPFGGDLLSHDFVEAAWMRRAGwdielapdmRGSAEDAP 314
                        250       260
                 ....*....|....*....|
Feature 1                            
gi 91787013  399 PDLlaelqRDRRWCQGNLQN 418
gi 146329303 351 PTLeelsrRERRWAQGNLQH 370
gi 189036520 368 PSIidlavRDRRWCQGNLQH 387
gi 114562481 362 PSLidvmiRDRRWCQGNLQH 381
gi 33301413  377 SNLldfatRDRRWCRGNIQH 396
gi 90419818  400 PTLpdfakRDLRWCQGNMQY 419
gi 32444759  324 TTLtdyaqRDQRWCQGNLQH 343
gi 69938827  380 PTLldmavRERRWAQGNLQH 399
gi 46206064  334 TNLidllgRERRWCQGNLQH 353
gi 126734550 315 QTLhaffrRDRRWCQGNLQH 334

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