Conserved Protein Domain Family
GT_2_like_d

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cd04196: GT_2_like_d 
Subfamily of Glycosyltransferase Family GT2 of unknown function.
GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Statistics
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PSSM-Id: 133039
View PSSM: cd04196
Aligned: 61 rows
Threshold Bit Score: 217.498
Threshold Setting Gi: 118587021
Created: 29-Jun-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Probable
Feature 1:Probable Catalytic site
Evidence:
  • Comment:Residues conserved among GT families of 2, 7, 13 and 43

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                           
gi 88800567   13 DVLILTYNGgsYLHPQLTSIAEQLep--gdRIIVSDDGSTDDTLRIlqefqqtylkenvellvyqGPGKGVIQNFFSG-- 88
gi 68644521    4 SVAMTTYNGadYLLEQLESLRTQSlm--adEVIIVDDCSTDNTVELldmyiqkyh-ldnwvlirnSSNIGWRKNFRKA-- 78
gi 134300870   5 TVLLSTYNGqaYLRELLDSVFAQKnv--iaSIVIRDDGSSDNTVDIieeyisng----yditllkESNVGATRSFHLLtq 78
gi 160894485   5 NVLVSTYNGekYIEEQLKSIDCQTys--nvHVYVRDDGSTDHTVELvnryirene-lsdkytvatGENIGFSKSFHLLm- 80
gi 24413066    5 AVLMATYNGekFISEQLDSIRQQTlk--pdYVLLRDDCSTDETVNVvnnyiakhe-legwkivknDKNLGWRLNFRQLli 81
gi 24637408    4 SVIIATYNGskFIEEQFDSILAQSvq--pdEVVITDDGSKDNTREVvqryidehdlnkkwhlhvnEKNKGYARNFLDG-- 79
gi 139439913  10 CIVLPTYNGgkYLAKQLDSILEQTwp--ncSVYIRDDGSTDETVEIaqwycrsns--sihliqdsIGNLGCPNSFYEIi- 84
gi 118587021   6 TVIMATFNGskYIHDQLQSIFNQSil--ptRVIIRDDKSSDDTAEIvnqfidgnnlraswdfkvnQKRKGWRENFISM-- 81
gi 68643740    6 AILMATYNGe-KYIKEQIESILNQdtdfdfTLIIRDDGSTDNTKNIireyvds-----gkiifieGQNKGAARGFISLl- 78
gi 29376675    8 TVVMATYNGekNILEQLDSLKNQSkk--idEVLIWDDCSTDSTVKIienfisenklgetwhlqinTENLGWRKNFFNL-- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        ##                                                              
gi 88800567   89 ---IQHTKAEYTFIADQDDVWLPGKRQLFAkq--mqCSSKPHLIFSDAWLWNSLDtntdtsfwqqqkinps---harqls 160
gi 68644521   79 ---LQETTGDIVFLCDQDDIWNKDKISLMVke--fhKSPSIELLASNYEILDFGRndkikirdveldngav---vpfslk 150
gi 134300870  79 yvyGQKEKTPFYAYCDQDDIWNPDKLNVAVdklralSEDLPNMYFSNLILYDGKTirnelafdvpcnf--------epqk 150
gi 160894485  81 ---QMADSGEYWAFCDQDDVWYPNKLSNAVkwmqtqKNDIPLLYQSKIAIGNSDLseivpykyenyny---------nfq 148
gi 24413066   82 --dVLAYEVDYVFFSDQDDIWYLDKNERQFai--msDKPQIEVLSADVDIKTMSTeasvphfltfsssdr----isqypk 153
gi 24637408   80 ---AMLTTGDIVFFCDQDDIWISDRVKKMSev--meKNPKINLLCSNLEPFYYEEdtrkwsekdlkamktdgsleicdlt 154
gi 139439913  85 ---KRVPEYDYYAFADQDDIWKTDKIERAVraiensGDKVPTVYFSSFSYVNEDGetiresapqdkyl---------sfh 152
gi 118587021  82 ---LRQTETDVVFYSDQDDIWQENKVEATLta--feAEEEMEVLVSDYVIIPKEQnllvvrqleetpvssq--lykvdlt 154
gi 68643740   79 ---CDNPGYDYYAFSDQDDVWNHNKLQKGIws--lsKYTGPALYCSNCELVDSELnsigrnthrkrpny-------tles 146
gi 29376675   84 ---LNAATKEIVFTCDQDDIWDASKIEVMCea--faNTDVKVLVSDYTELVEPGGlaeelkkidsvklpnqk-aeqiifn 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                                      
gi 88800567  161 tlifrntvqGASMAINRALIERISLHPdi---------vMHDWWCALHANa-fGSISIIFEPtllYRQHDANQIGALR 228
gi 68644521  151 nksisvmrpGCTFAVKRELIVLLEKYDid--------rfGHDNILWNLAMi-rGTLYLYLKRlihFRRHETSASAPNQ 219
gi 134300870 151 kafarvftyGCTCVFNQEALKTISLAGgen-------kiYHDNWLFEVCAf-lGNTVFDQSSyilYRQHSNNVSGEIK 220
gi 160894485 149 kaftsniffGFAMVINRELYDRLIRADfdq-------ikYHDWFAAIIVSa-fGKYVFSEEIeavHRQHENNASPLYF 218
gi 24413066  154 vydyqtfrpGWTIAMKRDFAQAIADNWtfg------aniSHDNLIETTASi-iGNGYNLNESvgvHIRYGGNASGNSK 224
gi 24637408  155 peyfhlkrsGCTMCIRKTFLEEIMPYWta--------nwPHDDFVWKMAVi-sSSCAILHFVsmrRRMHSNNATVIRV 223
gi 139439913 153 ntlfytpglGFTIVFNRLACRAFILEVdpg-------neMHDRWLIRCASa-fGKVLFDSVCtasHVRHSSAVTSGDN 222
gi 118587021 155 ltnlavyrpGCGMALRKSIIDSTIEIFrrvkvdfnavaqTHDQAAWLAAVa-rGTLYHLHQPlfiRRIHPDSTWQTEK 231
gi 68643740  147 ilclascaqGCTSVFNKELASIIQENDvpd------tfiMHDSLITCLCAligGKIIYDEIPsmkYRMHDDNIFGMVS 218
gi 29376675  158 ennlflrrpGCVYAIRKSFIANVNLYAsem------enpVHDMAMWGSSLl-sDGLYIVREElirWRKHGQSSFKKEI 228

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