Conserved Protein Domain Family
eIF-2B_gamma_N

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cd04198: eIF-2B_gamma_N 
The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2.
N-terminal domain of gamma subunit of the eukaryotic translation initiation factor 2B (eIF-2B): eIF-2B is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2.GTP complex. EIF2B is a complex multimeric protein consisting of five subunits named alpha, beta, gamma, delta and epsilon. Subunit gamma shares sequence similarity with epsilon subunit, and with a family of bifunctional nucleotide-binding enzymes such as ADP-glucose pyrophosphorylase, suggesting that epsilon subunit may play roles in nucleotide binding activity. In yeast, eIF2B gamma enhances the activity of eIF2B-epsilon leading to the idea that these subunits form the catalytic subcomplex.
Statistics
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PSSM-Id: 133041
View PSSM: cd04198
Aligned: 22 rows
Threshold Bit Score: 196.341
Threshold Setting Gi: 146450928
Created: 3-Mar-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966779     3 FQAVVMAVGg--GSRMTDLTSs-----iPKPLLPVGNKPLIWYPLNLLEr--vGFEEVIVVTTrdvqkalcaefkm---- 69
gi 3023677    39 FQAVVFAGF---GNSLYPLTGsd---alPKALLPIGNKPMLHYPLYWLEa--aGFTSAILICMeeaeahinawlrsgy-- 108
gi 46228677   14 FKGVIFAGGs--GRMLGPLAKn-----iSKAMIPVCNKPMIWYPLSNLIq--hRIRDICIFCEeefensirkyisetfsn 84
gi 57229191   19 FQAVILVGY---GENLYPFNQgtn--viSKALLPVGNVPIINCVIDWVLa--aGLLDILIIVPnafhdqiadhiaeaynk 91
gi 89286578    5 YQVVILAGGq--GTELYPLCEr-----fPKALLPVNNKPLIIYQLEKLEs--nGFTNVLILTSkntskieryikeyy--- 72
gi 74025334   18 FDIVVFAGGk--APGLNPLCDn-----ePKPMLCICNRPMIWYCLSPWIk--aGCSTFFVCVNedyaalqsylcrefp-- 86
gi 146450928   3 FTAVILCGN---GKALFPFSEtrs-tglPKALIPVANKSILTYVLDWCFt--aSFSKILVVTSqesseqvqteidafqne 76
gi 116508385  15 FLAVLIAGF---GNELLPLTSdhgdepyPKALLPVANKPLLEYILSWLEq--aGIKDVLLICPaihrpalyhhihsdvs- 88
gi 145521406   5 YQAIILGGGqkaGSMLFPLCQd-----ySKSLLPICNKPMILYQLDLLEtagfGPQDILILLTknhqavadlvq------ 73
gi 49650114    5 FKVFILCGQ---GKNMAPLSSvra-sgvPKALLPMANVPVIDYTLKWCEt--iPNPKVFVCCStadeaeisayvdsfka- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966779    70 -----------------kmkpdivcipddADMGTADSLRYIYPkl----------ktDVLVLSCDLITDValhevv---- 118
gi 3023677   109 --------------eghmrihveaptildDSKSSADALRAVSHliksqkmltdthqnDFVCLSCDSIVGLppiygldk-- 172
gi 46228677   85 dtiikrfefeetyqqnikiiglkedesllESSGTWSILSEYGKefl--------rdsDFFVLTCDVIGPLdllgla---- 152
gi 57229191   92 sthsr---vrinlrknsegerdedegdseEKDGTARILKKFRSfi----------ksDFVLLPCDISPPSylplktil-- 156
gi 89286578   73 ----------------qgqvkyelitipdEKKETFEAIRHVSNki----------nkDFILIACDSITDLglddvi---- 122
gi 74025334   87 --------------kvafvfvlvpltqnqTPTTTCDVVRGYLKhkeslksdrlskprDALLLSCDTFLPGvdvehfi--- 149
gi 146450928  77 krlnl--sldlkdydksttsnvsidlmgiTADHSGEAIYNICTeskyk-----ietqNFIILSCDFITNLppqvliem-- 147
gi 116508385  89 -------------spslridlqtyeetqeSPAGTCELLRHFSNri----------teDFVLVPCDFLAPPslplsqllnt 145
gi 145521406  74 -------------------rraeifyvseDSESGSALLEAHEKik-----------kDFILLSCDSMIGAnildll---- 119
gi 49650114   78 -------------ehstsvvasnvticskTDAKSGDFILELTRge----------psDFIVVGCDFITDIpasslvd--- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966779   119 --dlfrayDASLAMLMrkgqdsiepvpg---------------------------------------------------- 144
gi 3023677   173 frldnpsaLAVYSPVLkyehitsq-------------------------------------------------------- 196
gi 46228677  153 --nkhrltQAVCTILLtespdlskikgsgkqtsnsnn------------------------------------------- 187
gi 57229191  157 -dkhrsspKAVMTSVFyepiesv--------------------------------------------------------- 178
gi 89286578  123 --eqhiltGAYLTAVLkedkvdeennki---------------------------------------------------- 148
gi 74025334  150 --hnfyasVASVSVLLfrpisssngnscgtqlgptargnsastpagsgkgnkgsqgsgacaakpythhftcvayeeksgd 227
gi 146450928 148 -frnrpsnQLGITVAYrnqldiedkk------------------------------------------------------ 172
gi 116508385 146 frvestsdNNLLTTCWypvhvpdktvl----------------------------------------------------- 172
gi 145521406 120 --dfhyskKATITCLIkeedldkkqgr----------------------------------------------------- 144
gi 49650114  132 -tyrsrdsDSLLTAFYypntlenvdk------------------------------------------------------ 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966779   145 -------------qkgkkkaveqrdFIGVDSTGK-RLLFMANEADLDEElvi---kgsILQKHpriRFHTGLVDAHLYCL 207
gi 3023677   197 -----------------skeidakqLIGIEEKTS-RLLYAKSSADVGSDftf---rmsLLWKHprvTLNTNLSDAHIFVF 255
gi 46228677  188 ----qaqanpiggisvdlqkdknrsIFVIDEKDE-VILSIKDFYSAKQEnevselsklQLFWHpnvSLRTDLVDLHVYLF 262
gi 57229191  179 ------------------kdaeekiLVGLDKTSD-ELLLITPLEGMEEDlel---rmsLLNRHptlSLTTRILDAHVYVF 236
gi 89286578  149 --------------inpsssadnhdVFLIDETNN-KILYVNSFYEIKENglki--kksILASNpeaSIKTNLFDSHIYIC 211
gi 74025334  228 hvrndnnnngsalcpvasgvtensnKGSNCVSHH-RLHFICPREDEPEPcis----fgFAARRpnlTFAADVVDVHAYLV 302
gi 146450928 173 ----------------lkvfpkkytVYSDDSLMGsCLLDQYTKEDTDMSkvll-irskMCFTYpnsVISTKLLDSGIFMG 235
gi 116508385 173 --------------sdewgpapsppAIVVDPATG-SLLHIDTPDDRDRNnedfqfsmgMISRFsrtKLTASFQDSHVYIC 237
gi 145521406 145 --------------apiscnldesfDIMFIGSDQ-SLLHITSQEDDDQVnlqv-srnvLLSCQs-vQIMTNLFDTHVYVC 207
gi 49650114  157 ----------------ksllkdvtvHSSLDSRTP-RLLDSYSRDYIENKktmp-irrsMLWHFpksLVSTQLLNASVYFC 218

                 ....*
gi 9966779   208 KKYIV 212
gi 3023677   256 KHWVI 260
gi 46228677  263 KSSIF 267
gi 57229191  237 RRTFL 241
gi 89286578  212 KRQIL 216
gi 74025334  303 RNWVL 307
gi 146450928 236 SREIF 240
gi 116508385 238 QNKIL 242
gi 145521406 208 QYEVL 212
gi 49650114  219 TADVC 223
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