Conserved Protein Domain Family
GT1_Glycogen_Phosphorylase_like

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cd04299: GT1_Glycogen_Phosphorylase_like 
This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The members of this family are found in bacteria and Archaea.
Statistics
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PSSM-Id: 99995
View PSSM: cd04299
Aligned: 41 rows
Threshold Bit Score: 1155.77
Threshold Setting Gi: 55975605
Created: 23-Jun-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative activeputative
Feature 1:putative active site pocket [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         # #             
gi 2660639     12 LESLAYNLWWSWSRpaqrlwrmiDSEKWEEH-RNPVKILREVSKERLEELSKDedfiALYELTlERFTdymeREDTWFN- 89
gi 119961238   23 LARLATNLRWSWHRptrelfaslNPALWEESqHDPIALLGSISREQLQDLANDgelvNRVQGAaADLDry-lSEPRWYQg 101
gi 15608468    22 QLSTNLRWSWDKPTqdlf--aaiDPALWEQCgHDPVALLGAVNPARLDELALDaeflGALDELaADLNdy-lSRPLWYQe 98
gi 119716045   20 LGRLAGNLRWSWDPesqdvfesiDPVLWESTgRDPVKLLGAVGRRRLEELAADegflARLGVAvGHLDqy-lTGDRWYQr 98
gi 158520866   20 LEVLVRNLWWCWNLevidlfrriNPKLWEESgRNPIIFFTMIDQNQLDRLAEDtsflTNMAEVkEKFThd-vMAPSADAg 98
gi 148272579   20 LDELAGNLRWSWYEptrrvfahvSPELWEGTgHDPVALLGAVDQERLRELAADegfvAWAEEQrADLRay-vREPRWYQ- 97
gi 84494479    20 LGDLAMNLRWSWHPplrdlfesiDPERWASVgSDPVAMLSATPVEELDRLAADdtfvARVEDAkRGLDdy-lGQDRWYQ- 97
gi 72160990    20 LCTLAANLRWTWHAptravfaavEPRLWEAVgRDPIRLLGEVTPERLRELAADaefrARLDAAaADLDry-lTAPLWYQq 98
gi 117927888   20 LAELVMNLRWSWHPptlelfaaiDPLVWRAVrGDPVRLLGEVPPSRLAELAADegflRRLDHAlEDLHay-lTGDRWYQt 98
gi 134102653  627 LGTLATNLRWTWHPptqdlfasvDPEVWSAVgGDPLRLLAEVPAGRLSRLARDedflARTRAVdDDLRry-lTVPRWYQq 705
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            ###                                          
gi 2660639     90 ---VNYPEWDEKi-----vYMCMEYGLTkALPIYSGGLGILAGDHLKSASDlglPLIAVGLLYKHGYFTQQIdsDGRQIE 161
gi 119961238  102 --lGEDAPACIA-------YFSPEFGITeVLPQYSGGLGILAGDHLKAASDlgvPLIGVGLLYQAGYFKQSLsrDAWQQE 172
gi 15608468    99 ---QQDAGVAAQalptgiaYFSLEFGVAeVLPNYSGGLGILAGDHLKSASDlgvPLIAVGLYYRSGYFRQSLtaDGWQHE 175
gi 119716045   99 rlaAGEEGPRAIg------YFSPEFGITaVLPQYSGGLGILAGDHLKAASDlgvPIVGVGLLYRHGYFKQALsrEGWQQE 172
gi 158520866   99 --pRPRGEKEVIa------YFSMEFGIHeSLPLFAGGLGILAGDHLKAASDlglPIAGVGLFYTNGYFHQYLnhDGWQQE 170
gi 148272579   98 ---QLEGDVPEAi-----gYFSPEFGIAaALPQYSGGLGILAGDHLKSASDlgvPLVGVGLFYRSGYFRQGIssDGWQQE 169
gi 84494479    98 ---QWATEQGEAgapaaiaYFSPEFGIAaALPQYSGGLGILAGDHLKAASDiglPIVGVGLFYKTGYFRQSFnrDGWQQE 174
gi 72160990    99 l-tDSSDTPPPAai----aYFSAEYGLDaTLPQYSGGLGILAGDHLKSASDlgiPVIGVGLLYRHGYFSQTLspDGWQLE 173
gi 117927888   99 --tAVDGPRAVA-------YFSPEYGITsVLPQYSGGLGILAGDHLKTASDlgiPLIGVGLLYRRGYFNQSLsrDGWQQE 169
gi 134102653  706 ---RQDEGGLLPds---vaYFSMEFGVAeALPNYSGGLGVLAGDHLKSASDlgvPLVGVGLLYRSGYFRQALssEGWQVE 779
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 ## #    
gi 2660639    162 IFPEydIEglpMKPLRded-----gnQVIVEVPI-DNDTVk-aRVFEVQVGRVKLYLLDTDFEENEDRFRKICDYLYNPE 234
gi 119961238  173 TYPVldPDglpLTLLRhpakdgaqgkPVHISLPLpNGRELh-aHVWRADVGRVPLLLLDSNVPSNDEAARGITDRLYGGG 251
gi 15608468   176 TYPSldPQglpLRLLTdan-----gdPVLVEVAL-GDNAVlraRIWVAQVGRVPLLLLDSDIPENEHDLRNVTDRLYGGD 249
gi 119716045  173 TYPVldPDglpISLLReen-----gaRAMISVAL-PDGPEllaRIWVASVGRVPLLMLDTDVEGNPDHYRDVTDRLYGGN 246
gi 158520866  171 EYPAtnLYhlpVERIKdas-----gnELRVSFMG-PDGIIq-lSIWKIAVGRVSLFLLDTNIKENPPAIREINSRLYRAT 243
gi 148272579  170 TYPVfdPDglpLQVLRdad-----gaPVHVALELpADRTLh-aRIWQARVGRIPLLLLDTDVPENDDDLRGVTDRLYGGG 243
gi 84494479   175 DYPVldPDglpLALLReed-----gtPSVILIKLpGGRELr-aQVWRAQVGRVPLLLLDSDIPGNDDAARAVTERLYGGG 248
gi 72160990   174 RYPEidPHclpMTRLEdr------gtPVRITVDLpENRTLt-aHVWIVRVGRVPLLLLDTYHDDNDLDLRGVTDRLYGGG 246
gi 117927888  170 RYPPidPYglpLELLTead-----gsPVSIAIQLpEQRTLq-aRVWQARVGRVPLLLLDSDVEGNAPAERDVTDRLYGGG 243
gi 134102653  780 HYPVldPRalpLETVNdra-----gsPVLVRVAMpEGRTLr-aRIWKAQVGRVPLLLLDTDLPENDDDLRGTTDRLYGGD 853
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                                 # #                                      ##
gi 2660639    235 pDVRVSQEILLGIGGMKLLKTLKIK-----PGVIHLNEGHpAFSSLERIKSYMEeg----ySFTEALEIVRqTTVFTTHT 305
gi 119961238  252 gDHRLQQELLLGMGGVKALRVYQELtgtpaPEVFHTNEGHaGFLGIERIQEAMSdah-eplSWDEALAAGRaSTVFTTHT 330
gi 15608468   250 qEHRIKQEILAGIGGVRAIRAYTAVekltpPEVFHMNEGHaGFLGIERIRELVTda---glDFDTALTVVRsSTVFTTHT 326
gi 119716045  247 sEHRLRQELLLGVGGVRALRTYSRLsghpaPEVFHTNEGHaGFLGLERIRELTVaeggpklDFDTALEVSRaSTVFTTHT 326
gi 158520866  244 gKARLAQEVILGIGGMRALKAMGYT-----PVVCHMNEGHcSFSTVERLAQIRAqh---qvDLKTAIEINArTTVFTTHT 315
gi 148272579  244 gEHRLHQELLLGIGGVRAIAAHARVtgapvPRVFHTNEGHaGFLGVERISTLMAdg----lDFDEALQVVRaGTVFTTHT 319
gi 84494479   249 gEQRLQQEMLLGVGGVRALRLWSRLtgaptPDVYHSNEGHaGFLAIERISELVTsa---glTFDEALEAVRgATVFTTHT 325
gi 72160990   247 tEQRLRQELLLGIGGLRAVRAYCLRtgypePEVFHMNEGHaGFLGLERLREYIEta---glDFDQALEATRsGTVFTTHT 323
gi 117927888  244 tDHRFRQELLLGVGGVRAVRAFCRItghpePEVYHMNEGHaGFLALERISELMQda---glSFDEALEVVRaSTVFTTHT 320
gi 134102653  854 aDHRIRQEILAGVGGMRAVRAYCELsghpqPAVFHTNEGHaGFLGLERVRELQDdh---glQFDEAVVAVRaGTVFTTHT 930
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                      ##                                                    
gi 2660639    306 PvPAGHDRFPFDFVEKk-------LTKFFEGFESKELLMNLGKde-----dgNFNMTYLALRTSSFINGVSKLHADVSRR 373
gi 119961238  331 PvPAGIDRFETVQIKHf-------FEAGLAPAVPTERILELGRenfdggnpsVFNMAVMGLRLAQRANGVAKLHGVVSRE 403
gi 15608468   327 PvPAGIDRFPLEMVQRyvndqrgdGRSRLLPGLPADRIVALGAedd----paKFNMAHMGLRLAQRANGVSLLHGRVSRA 402
gi 119716045  327 PvPAGIDRFPLTLIEQy------fSEAGPTPGVPVERVLALGTedyeggdpaVFNMAVMGFRLAQRANGVSQLHGHVSRG 400
gi 158520866  316 PvPAGHDEFPPDLVRPy------mVPYETDLGVTADELVRWGQvegt-dpyrPFSMFVLGLHLAQDLNGVSELHGQVARR 388
gi 148272579  320 PvPAGIDRFDVGLVRKh-------VTERLLPGVPPERVLGLGAeahdggspdVFNMALMGLRLAQRANGVSQLHGEVSRG 392
gi 84494479   326 PvPAGIDRFERRLIEIy------fGGDLAPAGVPLDRLLSLGAetyeggdasMFNMAVLGLRIAQRANGVSKLHGVVSRD 399
gi 72160990   324 PvPAGIDRFPKELVERh------fSGPVALPGLPVERVMALGAetypggdpnVFNMAVMGMRLAQRVNGVSALHGAVSRE 397
gi 117927888  321 PvPAGIDRFPRDLIERhlvaetdgPARDGLHILPADRVLALGAeaypggdpgVFNMAVLGLRVASRANGVSTLHGAVSRH 400
gi 134102653  931 PvPAGIDRFPVDLVRHyfg---dgSPQALVPGVPTERVLALGAeen----pgMFNMAHMGLRLAQRANGVSQLHGGVSRK 1003
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #      #                                               
gi 2660639    374 MFKNvWKGVPVEEIPIEGITNGVHMGTWINREMRKLfdRYLGRVWREHtd---lEGIWYGVDRIPDEELWEAHLNAKKRF 450
gi 119961238  404 MFAGlWPGFDHSEIPITSVTNGVHVPTWVDPRISSLa-RNQFGAEAEA------LGRWDLAYNVSDEDVWALRRELRAQL 476
gi 15608468   403 MFNElWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLg-RELAGSDSLRe-----PVVWQRLHQVDPAHLWWIRSQLRSML 476
gi 119716045  401 MFNGlWPAFDEAEVPIGSITNGVHAPTWVAREVIEL--AIAQGADPESdd---tSGFWAAADKVPGTEIWAVKRVLRERL 475
gi 158520866  389 MWAHvWPRLPEEETPISHITNGVHIPSWISIENALLyqRYLGRDWSMStw---nSELSGRIADIYDEELWRAHEMSRTRL 465
gi 148272579  393 MFAGlWPGFDTDEVPITSVTNGVHAPTWTDPMLMSL--ARERLGTWDT------TAADWSSPAVTDGDLWDVRGRMRRQL 464
gi 84494479   400 MFDGlFPGFDADEVPITSITNGVHGPTWVDRKVYELa-ARHSDDVTIDttvldsEASWNAMADLPRDEVWAVKRQLREQL 478
gi 72160990   398 MFGGlWPGFDVDEVPITSITNGVHAATWMAEEAWDA--AQAMGLGLEEle---tPAGWQRLVERDAEELWRMRRALRERL 472
gi 117927888  401 MFAGlWPNFDPDDVPITSVTNGVHVPTWLAGEMRTLleTELAGPAGVDga--geGIRWADAERLDDVRLWQVRNALRARL 478
gi 134102653 1004 MFRGlWPGFGTEEVPIGSVTNGVHGPTWSARELGKLlgESEMDSGAGL------RGMEPVSDSLLWELRCSLRQRLVDEV 1077
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        ## # ###                         #    #  #       
gi 2660639    451 IDYIRESIKRRner-----lgiNEPLPEISENVLIIGFARRFATYKRAVLLFSDLERlKRIVNNSERPVYIVYAGKAHPR 525
gi 119961238  477 IDDVRRRLRASwkkrgaadaelGWTDSVLDPDVLTIGFARRVPTYKRLTLMLRDPARlKALLLDPKHPIQLVIAGKSHPA 556
gi 15608468   477 VEDVRARLRQSwlergatdaelGWIATAFDPNVLTVGFARRVPTYKRLTLMLRDPDRlEQLLLDEQRPIQLIVAGKSHPA 556
gi 119716045  476 VVDARRRLRRSwekrgaakaelSWIDNALDPDVLTIGFARRAASYKRLTLMMRDPERlKSLLLHPERPIQLVIAGKAHPA 555
gi 158520866  466 IRSCRKWMVQQygrrnapksvmKEAESVLDDGVLTIAFARRFASYKRATLLLRDMDRfEAILKSEECPVQFIFAGKAHPK 545
gi 148272579  465 VEDARRRVVRAwreqnpgavepAWLEDVLDPEVLTIGFARRVPTYKRLTLMLHDRERlRRILTDPERPVQIVVAGKSHPA 544
gi 84494479   479 VVEARARMRASwikrgassaelGWTDEILDPDVLTIGFARRVPTYKRLTLMLRDPARlKKLLLDPERPIQIVIAGKSHPA 558
gi 72160990   473 IIEARKRLRASwrqrgatdaelAWIDEALDPEVLTVGFARRVPSYKRLTLMLRDPERlTALLRHPERPIQIIIAGKAHPA 552
gi 117927888  479 VVEARARLRESwrtrgatdsemQWIDDALDPQVLTIGFARRVPSYKRLTLMLRNPERlRALLLHPRHPVQIVIAGKAHPA 558
gi 134102653 1078 RRRLRHAWRQRgasd----lelGWCDSVFDPDVLTIGFARRVPTYKRLTLMLRDTELlRELLLDPERPVQVVVAGKSHPA 1153
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                       ##                     # ####  #                  
gi 2660639    526 DEGGKEFLRRIYEVSQMPDFKNKIIVLENYDIGMARLMVSgVDVWLNNPrRPMEASGTSGMKAAAnGVLNASVYDGWWVE 605
gi 119961238  557 DDAGKKMIQDLVKFTDDPQVRHRIVFLPNYDIAMARTLFPgCDVWLNNPlRPLEACGTSGMKAAInGSLNLSVLDGWWDE 636
gi 15608468   557 DDGGKALIQQVVRFADRPQVRHRIAFLPNYDMSMARLLYWgCDVWLNNPlRPLEACGTSGMKSALnGGLNLSIRDGWWDE 636
gi 119716045  556 DDGGKKLIQDIVKLSDDPEIRHRIVFLPNYDIAMAKPLYPgCDVWLNNPlRPYEACGTSGMKAALnGGLNLSVLDGWWDE 635
gi 158520866  546 DDEGKRLIQQLVHFARHPLYRHKILFLENYDINIARHLVQgADVWLNTPrRPMEACGTSGMKAAAnGVLNVSILDGWWCE 625
gi 148272579  545 DDEGKRLIQELVRFAAEPGIRGRLVFLPDYDIGMAQLLYPgTDVWLNNPlRPLEACGTSGMKAALnGALNLSILDGWWNE 624
gi 84494479   559 DETGKQLIQQMIKFTDDPEVRHRIAFLPNYDIAMAQHLYPgCDVWLNNPlRPFEASGTSGMKAALnGALNLSILDGWWDE 638
gi 72160990   553 DEGGKRLIQEMVRFSDDPRVRDRIVFLPDYDMALAALLVQgCDVWLNNPlRPLEACGTSGMKSALnGGLNLSIRDGWWDE 632
gi 117927888  559 DDAGKRLIQEVVKFADDPEVRHRIVFLPDYDMALAQLLIAgADVWLNNPlRPLEACGTSGMKAALnGVLNLSIRDGWWDE 638
gi 134102653 1154 DEGGKVMIQKIVQFADQADVRHRIVFLPDYDMALARYLVSgCDVWLNNPvRPLEACGTSGMKAALnGGLNLSVRDGWWDE 1233
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 2660639    606 GYNGRNGWVIGDEs-vLPETEADDPKDAEaly----elLENEIIPTYYENREKWIFm----------MKESIKa-----w 665
gi 119961238  637 MYDGENGWAIPTAn-nNASSEERDDIEASalyelletqVAPRFYGTTVAQGAGAAGpsessretvptHWVSMIkhtlanl 715
gi 15608468   637 WYDGENGWEIPSAdgvADENRRDDLEAGAly-----dlLAQAVAPKFYERDERGVPq----------RWVEMVrhtlqtl 701
gi 119716045  636 WYDGDNGWAIPTAd-gVEDPDHRDDLEAAaly----dlIENDVAPRFYDLDGEGVPn----------RWLEMTrhtlksl 700
gi 158520866  626 GYTPDVGWAIGNGe-eYDDHNYQDAVESQaly----nvLENDVIPCFYDRESGGVPe----------RWLAMMkasmhma 690
gi 148272579  625 YFDGGNGWAIPSAd-rAHDGAERDAMEATaly----dlIENRIAPRFYDRDADGVPv----------GWVHDIrhtlrtl 689
gi 84494479   639 WFDGNNGWAIPTAd-gVEDPERRDDIEANaly----dlIENQVAPRFYDVDGDDLPq----------NWLAMVmhtvstl 703
gi 72160990   633 WFDGSNGWAIPTAd-gVDDPDRRDDIEAAaly----elFEEQVAPLFYERDDHGLPr----------RWLETVkhtmvsl 697
gi 117927888  639 WFDGNNGWAIPSAd--GLPDDRRDDLEAHaly----diIESQVAPRFYDRGSDGLPt----------RWLEMIrhaiasl 702
gi 134102653 1234 MFDGHNGWAIPDAd-gVTDPNRRDDLEAAaly----elISTQVAPAFYERNTDGVPg----------KWMSMVrhtlatl 1298
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 2660639    666 LQNSAPPACCKEYTEKFYIkglvNREWLEr--rENVEKIGAWKERILKNWENvs----------iERIVLEDSKSVevTV 733
gi 119961238  716 GPAVSAERMLHDYVNNLYCpaavSGRRAVaesfKEAKELAAWTSKVRSAWPGvvvehv-dsvgvsEEPQVGDTLQVnaYV 794
gi 15608468   702 GPKVLASRMVRDYVEHYYApaaqSFRRTAgaqfDAARELADYRRRAEEAWPKieiadv-dstglpDTPLLGSQLTLtaTV 780
gi 119716045  701 GPKVLATRMVRDYVRQLYTpacvTAHRLNsd-fHGAAELAAWKKKVKTGWSAvrvdhv-essgvgDAPEVGDQMSVraFV 778
gi 158520866  691 LEGFCAHKMVNRYDTRFYTpgmeRYYELTengaARARQLNEVHDRLRNNWHTiaietp--erqtaGPFRIGQSLVIsvVV 768
gi 148272579  690 SPELSADRMVRQYVERLYVpagrAQAVVAadgsARARELAAWRGRVVAAWPSvqvahv-esegveHQAQVGDELRVraWV 768
gi 84494479   704 GPKVRASRMVREYTERLYVpaarSGWALKhddyAGARDLAAYTSRVKAAWPKvsvdhi-essgvgDSPEIGETLHVnaYV 782
gi 72160990   698 GPKVQATRMVREYVDQLYQpaalAMRRLAadnyRGARELAAWKQRVQHAWPGvriehv-etsmngDTPQVGGELEVraTL 776
gi 117927888  703 GPKVAATRMLREYLDRLYTpaacAHRAVTaddfAGARHLAAWKARILQAWPGvrvehv-aasglaDALEYGTRVPVraVV 781
gi 134102653 1299 GPRVQSSRMVREYVDHHYApaarSAAAVAvqgyRGAKEIADYRSRLSAAWTWvrihdtemavedgGTPLLGGQVVVraQV 1378
                         810       820       830
                  ....*....|....*....|....*....|
Feature 1                                       
gi 2660639    734 KLGDLTPNDVIvelvaGRGEGMEDLEVWKV 763
gi 119961238  795 ALNNLTPDDVSvevafGRAEDTDELEDIVV 824
gi 15608468   781 RLAGLRPNDVTvqgvlGRVDAGDVLMDPVT 810
gi 119716045  779 ALGSLAPDDVEvqllhGKTNGEDELVETLV 808
gi 158520866  769 HLGTLTPEEADvelyyGPLRDVDAVTGGKT 798
gi 148272579  769 GLGGLGAGDVTvevvhGRTGEGDVLTDVVR 798
gi 84494479   783 SLDGLAPEDVEvqvahGRTNHRGDDLHDIT 812
gi 72160990   777 VLGGLDPDDVCvevvlGLVNDDDELINPTT 806
gi 117927888  782 ALGGLDPSDVDvqvvyGRVDENDELVTPRS 811
gi 134102653 1379 DLAGLDPSDVNvevvvGRVDDSDELHDFVT 1408

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