2AH5,3SD7


Conserved Protein Domain Family
HAD_5NT

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cd04302: HAD_5NT 
Click on image for an interactive view with Cn3D
haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065
5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319798
Aligned: 20 rows
Threshold Bit Score: 279.861
Created: 3-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #####                                                                       
2AH5_A         6 AIFFDLDGTLVDSsiGIHNAFTYTFKELGvpspdaKTIRGf-XGPPLESSFatcls---kdqisEAVQIYRSYYKAKGiy 81  Streptococcus p...
NP_695924      8 VVLLDLDGTLTKSdgGIIASVVKTFEELGrpvpddAELHRf-IGPAIIESLrrnhvp--edeldRAVTIYRSYYADRAvf 84  Bifidobacterium...
NP_767138      6 SVFLDLDGTLVDSqpGIAASCSAALRVLGhd---pGKAPDiaIGPPLEDILrtllqaygddridEAVVAYRQHYGESGll 82  Bradyrhizobium ...
YP_001036270   6 HIFFDLDGTLVDSskGIQESFEYSFKQLGkec-peESIIKsfMGPPLEVSFasvle---esqvpEAINYYRSFYKEKGiw 81  Streptococcus s...
YP_001636400  11 AILFDLDGTLTDPftGIARSVNYALQRLGhpllsdDELRRw-IGPPLHASFeqlldd--prladQAVAHYRQRYWETGly 87  Chloroflexus au...
CAQ02278      20 CILFDLDGTITDSapGITAQLAKTLVFMGlpvpgpAQLLEy-VGPPILDSFrdlagm-dddaqqRALAHYREGYAGGGvf 97  Clavibacter mic...
YP_806032      3 NLFFDFDGTVADSevGIVAGLKYMVQDRGlrpldnSAYTQf-IGPALIDMLpkvwpelddievkRAIDAFHHYYEEEGly 81  Lactobacillus c...
P68910        81 LVIFDLDGTLTDSarGIVSSFRHALNHIGapvpegDLATHi-VGPPMHETLramgl---gesaeEAIVAYRADYSARGwa 156 Mycobacterium b...
NP_820149     34 YLLFDLDGTLTDPkeGITRSVQYALEQMNvacpsmDELEWt-IGPPLIDAFalllntkdkkqlqKAINFYRERYVDRCai 112 Coxiella burnet...
NP_638533      5 TLFFDLDGTLVDSepGIVGSIVHAFDEVGqprpspQTLRAw-IGPPLRDSFserfpe-dpdlvqRALAAYRARYDAVGwt 82  Xanthomonas cam...
Feature 1                                               ##                                    #  
2AH5_A        82 --------------eAQLFPQIIDLLEELSSs-yPLYITTTKDtSTAQDXAKNLEIHHFFDGIYGSSPea-----phKAD 141 Streptococcus p...
NP_695924     85 ddpnepgnkvpgrlvNVVFPGIREQLLKLRAdgyYLALASCKPeYQCVPICEHFHLTELLDGIYGASRdns---rldKDQ 161 Bifidobacterium...
NP_767138     83 --------------gSEPYPGISGALQELRQaglRIYLATSKReVFARRILENLNLAAYFDGIHGSVPggk---ldhKPE 145 Bradyrhizobium ...
YP_001036270  82 --------------gVRLYEGIPELLTQLKEagyQIYVTTSKNqPTAQKLLANLAISEQFDDIFGSLPds-----fhKAD 142 Streptococcus s...
YP_001636400  88 --------------eNTVFPGIPELLSDLKAagiRLFVATSKIrPPTERILAHFGLQPFFEAIAAVDPddr---dgnKAM 150 Chloroflexus au...
CAQ02278      98 --------------dSSVYVGVPEVLRAIHAagiPLSLATSKPeSQARRVLDHYGLTELFTEICGASEdev---rsaKAD 160 Clavibacter mic...
YP_806032     82 --------------qVELYPNFLDTMAKLKQqdnQLYIASAKPeTMLHRLVKHFSLDQYFAGAYGASDdeet--rvtKTD 145 Lactobacillus c...
P68910       157 --------------mNSLFDGIGPLLADLRTagvRLAVATSKAePTARRILRHFGIEQHFEVIAGASTdgsrgskvdVLA 222 Mycobacterium b...
NP_820149    113 --------------eNKPYDGIHETLETLVNhgyQLYLATSKPwAYAGKILDHFNLRDYFTAVHGSELdgt---rdyKEE 175 Coxiella burnet...
NP_638533     83 --------------eLSVFDGIGDVVTGLHRaghRLAVVTSKNeRYARRIVEHLPFGVCFEDVIGASEdga---rrfKPD 145 Xanthomonas cam...
Feature 1                              ##  ##                                           
2AH5_A       142 VIHQALQthql---apeqAIIIGDTKFDXLGAREtGIQKLAITWGFGEQadllnyQPDYIAHKPLEVLAYF 209 Streptococcus pneumoniae
NP_695924    162 VIRYCFDkigfdaaagdkAVMIGDRYTDIDGAHAcNLDAIGCRWGYAPAgemeehGAYEIIEKPEQIEEAV 232 Bifidobacterium longum N...
NP_767138    146 LLAHILSecgi---aashSIMIGDRHHDIAGAHAvKMRGLGVLWGYGNRdeleaaGADQLVERPADLARTV 213 Bradyrhizobium japonicum...
YP_001036270 143 VLRRALQtlda---npeeTIIIGDTKFDIIGGKEvGISTLGVLWGFGSQrellenGADLLSNSPKHILKIL 210 Streptococcus sanguinis ...
YP_001636400 151 VIGTLLPtlga---drawTVMVGDTIFDIHGARAhRMPCIAVTYGYGEYrdlylaAPLALASTVGTLRELL 218 Chloroflexus aurantiacus...
CAQ02278     161 VIEEALRrlraagvdlgnAVMVGDREHDVLGAAAhGIPTVMVGWGYGSPae--aaGTIAVVDTAAELEARL 229 Clavibacter michiganensi...
YP_806032    146 ILTYALKdsqv---aldqSVMIGDRANDMIGGKAnHVQLLGVTYGFGSAkelkeaGAKVLVDQPADIPAGL 213 Lactobacillus casei ATCC...
P68910       223 HALAQLRplp------erLVMVGDRSHDVDGAAAhGIDTVVVGWGYGRAdfi-dkTSTTVVTHAATIDELR 286 Mycobacterium bovis AF21...
NP_820149    176 LIGYVLDtqki---sntqSLMIGDRRYDILGAKHnNVRSIGVTYGYGSLeeiqeaGPDAVCDYHRLILPTL 243 Coxiella burnetii RSA 493
NP_638533    146 LIAEALRrlqi---dktgCVMIGDRRMDIDGANHhGIHSIGVLWGFGDEaelraaGAGALAHTPAELSGLI 213 Xanthomonas campestris p...

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