Conserved Protein Domain Family
HAD_PGPase

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cd04303: HAD_PGPase 
phosphoglycolate phosphatase, similar to Synechococcus elongates phosphoglycolate phosphatase PGP/CbbZ
Phosphoglycolate phosphatase catalyzes the dephosphorylation of phosphoglycolate; its activity requires divalent cations, especially Mg++. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319799
View PSSM: cd04303
Aligned: 9 rows
Threshold Bit Score: 274.619
Threshold Setting Gi: 27379815
Created: 3-May-2006
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                                                                       
gi 30262245    6 YIVFDFDGTLVDSQNIFVpiynqIAKKHGYKTvreeeieyLRKLTMPERCKqldvPLYKLPILAlefyklyqpaIKDLIL 85
gi 93141269    3 AIIFDFDGTLVDSLPTVVaianaHAPDFGYDPiderdyaqLRQWSSRTIVRraglSPWQQARLLqrvqrqlgdcLPALQL 82
gi 10955171    9 LIIFDFDGTLADSGAWILsalreMSERHRFVTpsdtqieyLRGLSICQVLRwlrvPVWRIPLIVkdlr--klarEATFDI 86
gi 16125889   35 LVIFDFDGTLADSAAWMMravnpMARRYGFKTvtedeiemLRGRSTREVIRylgvSPWKLPLIAragkklmaadAHTIPL 114
gi 115421305   5 LIAFDFDGTLADTLPWMEsilhdVAEKFGFRKpdaqeraqLRQHNAFDIMKqlgiPIWKAPAILgfvrqsmeeaVPKVAL 84
gi 169147210  10 AIIFDLDGTLADSFHFFLsvlnqLSAKYKFKSvelheveqYKHLSPKEIMKemnvSRWKLPWIAkdfirlmkerDQEVYM 89
gi 27379815   27 LAIFDLDGTLADSFPWFLrtindVADRFGFRRvadediegLRHASSREILSrlevPLWKLPAIArharrlkaeaASEISL 106
gi 21233047    4 LIIFDFDGTLADSFGFFLstqrtLAARHGFRAaeahevdaARRLTTRELLKhsglRSWRVPLVAadfir-lmraAPPPAL 82
gi 753328568   4 YIVFDFDGTLVDSQNIFVpiynqIAKKHGYKTvreeeieyLRKLTMPERCKqldvPLYKLPILAlefyklyqpaIKDLIL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             ##                                #                     ## 
gi 30262245   86 FHGMKDVLDELhkeGYGIAVISSNSeEHIRAFLHnn--dIENIQEVycs-knLFGKDKMIKRFlkskkitekdMLYVGDE 162
gi 93141269   83 FPGVADLLAQLrsrSLCLGILSSNSrQNIEAFLQrq--gLRSLFSVvqagtpILSKRRALSQLvaregwqpaaVMYVGDE 160
gi 10955171   87 FPRTEKVLLHLedqGVELAILSSNStENIRRVLGp----LDSYFTYiegsspLFGKGKRINKIlrrckksrneVLLVGDE 162
gi 16125889  115 FPETEKMLRALhaaGVKIAVVSSNSeTVIRRVLGeelgnLISLYACga---sLFGKARKFRQVtrqgv-ardkIICIGDE 190
gi 115421305  85 FPGIDAMLRALhasGARLAVVSSNStANVQRVLGpelsaLIHDFACgs---dLFGKPAKLEHLlratqteaaqAILIGDE 161
gi 169147210  90 FEGMRDHLMELhkrGYTLAIITSNSkENCQSILGk---eLCELFSHidggssIFGKAKRIKRVlnilnlnkeqAIYVGDQ 166
gi 27379815  107 FAGVEAMLRTLagnGVQLALVTSDSeANAREKLGea-aaLFAHFDCsa---sIFGKPAKFRRVirrasveldrVIAIGDE 182
gi 21233047   83 FPGVDAALRALhasGTRLALVSSNSvDNVQRALGa---eLSALFAVfeggahLLGKHRALRRVlratghtaaqAIYVGDQ 159
gi 753328568  84 FHGMKDVLDELhkeGYGIAVISSNSeEHIRAFLHnn--gIENIQEVycs-knLFGKDKMIKRFlkskkitekdMLYVGDE 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
Feature 1         ##                                         
gi 30262245  163 QRDVAACKKagvNVIWVSWGYDvietvkkdaPDYMVNTPMEIVQ 206
gi 93141269  161 TRDVEAARQvglIAVAVTWGFNdrqslvaacPDWLLETPSDLLQ 204
gi 10955171  163 VRDIEAAKSqniASAGVTWGYAkrealaysnPTHILEDIEDLID 206
gi 16125889  191 TRDIEAARAvglDCGAVGWGYAkpsilaqhgPTVSFNSMSEIIS 234
gi 115421305 162 IRDIEAARKvgvASGIVAWGYNreqvlreqaPDFVFTDVQDLAR 205
gi 169147210 167 TTDGEAAHKagiDFAAVGWGYTsaeklktiqPKVVLTDLATMKE 210
gi 27379815  183 VRDIEAARAvgiACGAVSWGYAapaalralaPDHMFAQMEDIAE 226
gi 21233047  160 VADWEAAQVlglPFAAVAWGYAhpdvfmqlpNTHLIEEVEGLIA 203
gi 753328568 161 QRDVAACKKagvNVIWVSWGYDvietvkkdaPDYMVNTPMEIVQ 204

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