1L8L,1NNL,3KD3


Conserved Protein Domain Family
HAD_PSP_eu

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cd04309: HAD_PSP_eu 
Click on image for an interactive view with Cn3D
phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase
Human PSP, EC 3.1.3.3, catalyzes the third and final of the L-serine biosynthesis pathway, the Mg2+-dependent hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, L-serine is a precursor for the biosynthesis of glycine. HPSP regulates the levels of glycine and D-serine (converted from L-serine), the putative co-agonists for the glycine site of the NMDA receptor in the brain. Plant 3-PSP catalyzes the conversion of 3-phosphoserine to serine in the last step of the plastidic pathway of serine biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319801
View PSSM: cd04309
Aligned: 14 rows
Threshold Bit Score: 257.981
Threshold Setting Gi: 281307162
Created: 28-Apr-2006
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #####    #                                                                 
1L8L_A        15 DAVCFDVDSTVIreEGIDELAKICGVEdavsemTRRAMGGavpFKAALTERLALIQPsrEQVQRLIAeqp--phLTPGIR 92
gi 3759179    84 EAVCFDVDSTVCvdEGIDELAEFCGAGkavaewTARAMGGsvpFEEALAARLSLFKPslSKVEEYLDkrp--prLSPGIE 161
gi 1002674     9 KCVCLDVDSTVCedEGLDEIASYIGVTdrvkkiTDEAMNGeldINKALEARLSIMNLnvKKLTDFLDnhp--vrLTPGVE 86
gi 24661601   62 QIVCFDVDSTVIceEGIDELAEYCGKGsevarvTKEAMGGamtFQDALKIRLNIIRPtqQQVRDFIQerp--stLSKNVK 139
gi 74315916   15 DAVCFDVDSTVIreEGIDELAKFCGVGdavtemTRKAMGGsmsFQTALSERLSIIKCsrEQVNKLITdhp--pqLTPGIR 92
gi 117970179  15 DCVCFDVDSTVIqdEGIDEMARFCGKGeevkrlTAEAMGGsmtFQEALKKRLDIIRPtvSQIRQFVAthp--vrLTPGVE 92
gi 167882329  99 QIVCFDVDSTIIteEGIDELAQYCGKGsevaalTKEAMGGsmtFQEALRRRLDIIKPsqRQIREFLKthp--stISGGVR 176
gi 115534454  54 DAVCFDVDSTVCqdEGIDELAAYLGVGeavanvTRTAMNGnarFRDALAARLQVMKPnhEQLEQFVNisk--pkLTVGIR 131
gi 112143952  87 DAICFDVDATVIreEGINRLATHNGCGeqieamTVRTMEGdtpFHEALRERLDIIRPsqSDVASLIAqnakdelLSPGVA 166
gi 61816942  111 DAVCFDVDRTVTtdASVGLLAKFMGIEdeaqslTEQANRGeinLTKAFEDRLAKLNFtpTDIDRFLEehpahtrLVPGVE 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        ##                                                        #     
1L8L_A        93 ELVSRLQerNVQVFLISGGFRSIVEHVASKLNIpaTNVFANRLKFYf-----nGEYAGFDEtqpt----aesGGKGKVIK 163
gi 3759179   162 ELVKKLRanNIDVYLISGGFRQMINPVASILGIprENIFANNLLFGn-----sGEFLGFDEnept----srsGGKAKAVQ 232
gi 1002674    87 NLVNQFKenGIDVYLVSGGLYPLVSRVAELLNIpeENVYANKLIFNn-----eGTYVGLDHnapt----srsDGKALIVN 157
gi 24661601  140 RFVSHLKaeGKQVYLISGGFDCLIAPVANELGIplKNVYANKMLFDy-----lGEYDSFDInqpt----srsGGKAEAIA 210
gi 74315916   93 ELVQKLQqrGVQVFLVSGGFRCIVEHVASQLSIplQHVYANRLKFYf-----nGEYAGFDEsqpt----aqsGGKGRVIS 163
gi 117970179  93 QLVKSLHerGVTVYLVSGGFRCLIEPVAEILGIplTNIYANRLKFFf-----nGEYAGFDDtept----srsGGKGLVIR 163
gi 167882329 177 ELIDQLRrnSAEIYLVSGGFDCLIEPVADALEIplCNLFANKLYFHf-----nGSYAGFDTnqvt----sksGGKGEAIK 247
gi 115534454 132 ELVSRLHarGTHVYLVSGGFRRLILPVAELLGIekSRIYANEILFDk-----fGKYHGFDTseltsdsgskeTGKPAVIA 206
gi 112143952 167 DLVRSLHesGRPVFLLSGGFRQIINPFAAQLGVeeSHVYANTLLFDe-----qGDYSGVDPtelt----sqpSGKARVIS 237
gi 61816942  191 NLIAALKarGVEVFLISGGFREMALPIASHLKIpaKNVFCNTMSWQlddhgepVRLQGLDMtra-----aesHFKSRAIE 265
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                       ##  ##                                        
1L8L_A       164 FLKEKfhf-kkIIMIGDGATDMEACPPA-------DAFIGFGGNVirQQVKDNAkWYITDF 216
gi 3759179   233 QIRKGrly-ktMAMIGDGATDLEARKPGg-----aDLFISYAGVQlrEAVAANAdWLIFKF 287
gi 1002674   158 ELLNKlh--tpVMMIGDGMTDAKACPPA-------SVFIGFGVNVirPKVKAISdYFCTSV 209
gi 24661601  211 LIRKEnsddslITMIGDGATDLEAVPPA-------NYFIGFGGNVvrPEVYRRAqYYVTDF 264
gi 74315916  164 MLKEKhgf-qnILMIGDGATDLEACPPA-------SAFIGFGGNVlrPQVKEKSsWYVSSF 216
gi 117970179 164 RLKEQhsy-qrVIMIGDGATDAEASPPA-------EGFIGFGGNVmrEEVKKRAsWYVTDF 216
gi 167882329 248 QIKGRfnsnkvVAMIGDGMTDLEACPPA-------DLFIGYGGNAvrEEVQKRAtYYVTNF 301
gi 115534454 207 LLKKMyny-ktVVMVGDGATDVEASPPA-------DAFIGFGGNVirEGVKARAkWYVTDF 259
gi 112143952 238 MLKEThgf-ekVVMIGDGANDMSARDCPdhaangaDVFIGFGGVKvrETVRQGAdWFVTDF 297
gi 61816942  266 RIRRKypy-nnIIMVGDGFSDLEAMQGSpd---gaDAFICFGGVMqrPAVASQAdWFVRSY 322

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