Conserved Protein Domain Family
Bromodomain

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cd04369: Bromodomain 
Click on image for an interactive view with Cn3D
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99922
View PSSM: cd04369
Aligned: 278 rows
Threshold Bit Score: 42.3594
Threshold Setting Gi: 116510726
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:
  • Structure:1E6I: Bromodomain From Yeast GCN5 complexed with acetylated H4 peptide
    View structure with Cn3D
  • Structure:1JM4: NMR structure of human PCAF bromodomain in complex with HIV-1 tat peptide
    View structure with Cn3D
  • Structure:1JSP: NMR structure of human cbp bromodomain in complex with P53 peptide
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #                  #  #                          
1E6I_A         14 HDAAIQNILTELQnh-------aaAWPFLQPVnk--------------eeVPDYYDFIKEPMDLSTMEIKLEsn-----k 67
gi 147787325  300 SREEIDDLMGIFYsime----nenAPVFRGRHds--------------qrRARYKKLVRQHMDFDTIRSRINsh-----l 356
gi 15230910   271 IFVESQPLSDFIEilqs----hpiGSHFSRRLet--------------qeTSDYYRIIRQHIDFEMIRSRVEeg----yy 328
gi 2443880    253 SLALPKELMKIYNtiaq----necALVFRRRLds--------------qkRGRYKKLVRRHMDLDTVQSRINgc-----s 309
gi 7076764    299 AGDKSQPLIDIIKlirs----hprGSVFESRLrs--------------qdTKDYKRLIRQHLDMKTIEKKMEkg----sy 356
gi 28830197   287 YRPKVKTTKPILNel--------mIDHLKSMVlqlmkdtrtkqirepfgdQSKYKDHIKNPMDLGTIEKRLTtk-----y 353
gi 147768907  333 ICVKSQPLVSFLEiirs----hkhSSLFERRLet--------------qeTEVYKSIVRQHVDLESIQTKLDdg----ty 390
gi 89284034   751 PILKDDKLYDEYKnnlrq--qyrcTNYFQKFFtkne-----------fekIPNYLKLIKKPIDLYMMQRKAIsgd---yd 814
gi 71073409   222 TTVAVTDLFLTYKradygdvlmkvELIRKLSLee--------------iqNVDKKSIIDWCYRIGAMAANKCdeerrpkp 287
gi 148612838   78 ELQQGYRILGEFLqekhrgltapfLQPLGGVAtaeeevae---gprsggrGGRAFPQQPGQGMCLLQMEEKFas----gq 150
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
Feature 1                          #   #           #               
1E6I_A         68 YQKMEDFIYDARLVFNNCRMYNGen------tsYYKYANRLEKFFNNKV 110
gi 147787325  357 ITTSRELFRDLLLLANNALVFYSkk------srEHKSAVLLRDLVSRRL 399
gi 15230910   329 KTARTKFFRDLLLLINNVRVFYGep------spEFNAAKQLYQLIKKQM 371
gi 2443880    310 ISSAKELFRDFLLVANNAAIFYSkn------trEYKSAVGLRDIVTKSL 352
gi 7076764    357 VSSSLSFYRDLKLLFTNAIVFFPts------ssESIAAQELRTLVSNEM 399
gi 28830197   354 YKDYQIIYQDIKLVFSNVMEIVNaaiaandsndPMESVEELDKEFEEQY 402
gi 147768907  391 SSSPRAFYRDLLLLFTNAIVFFPka------saEALAAGELRAMVLNEV 433
gi 89284034   815 NEPYEQLYKDFLLLIQNALNFNAhh------peAYREATKLNLLGRTAF 857
gi 71073409   288 YRSAQELLRDLLLIAFNARRYNSld------hfLHKMGGSMLADIRSAW 330
gi 148612838  151 YGGITEFVADFRLMLETCYRLHGvd------hwISKQGQKLEMMLEQKL 193

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