1KQG,1H0H,1Y4Z,1TI6,2VPW


Conserved Protein Domain Family
DMSOR_beta-like

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cd04410: DMSOR_beta-like 
Click on image for an interactive view with Cn3D
Beta subunit of the DMSO Reductase (DMSOR) family
This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.
Statistics
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PSSM-Id: 319870
View PSSM: cd04410
Aligned: 74 rows
Threshold Bit Score: 60.8658
Threshold Setting Gi: 836454970
Created: 18-Aug-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Fe-S cluster
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Structure:1KQG_B; Escherichia coli Formate Dehydrogenase N binds to 4[Fe-S] clusters, at 4A distance.
    View structure with Cn3D
  • Structure:1H0H_B; 1H0H_b; Desulfovibrio gigas Formate Dehydrogenase binds to 3[Fe-S] clusters, at 4A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #      ####   ##   #   #                        # #                         #  #
1KQG_B        32 KLIDVSTCIGCk--ACQVACSEWNdirdevghcvgvydnpadlsakSWTVMRFSeteqng---------klewlIRKDGC 100
gi 913268218   6 KTDGMNKCIGCf--TCMLVCSGVNqqn----------------hsiSKSAIKIRtsgg------------lqgkFVVDVC 55
gi 931454784  18 LFIDLDICSTGeckECVIKCSYLYh--------------------pDNNGIISVae----------------laTYCLVC 61
gi 951282795  57 VDDFTSKCISCg--ICADVCRQLGynaitf----------tslkdgLSSALPVVk------------------dMRDNPC 106
gi 389401301  14 WEGMLSKCIRCg--YCYEHCPMFKytr----------------wesDAPRAKNIlahglltge---veltpeiaEKSFSC 72
gi 694166984   4 ISFEKERCMTCh--NCELGCATVHs--------------------sGKNLISAIeenvmprih--iifnekknvVAAEQC 59
gi 11095245   43 VIFNKNLCVACh--SCEVSCSIIHs--------------------sEKSLISAIlegirprlqivyttgdktggITIEQC 100
gi 599129005   4 INIKSEYCVNCq--QCENVCSNLWfke----------------inkEKSCIRILnen---------------dgIKITVC 50
gi 931520160   4 LFVDLEICSQCk--ECKVCCDYFYh---------------------PQNNGVANlre---------------yaTFATIC 45
gi 114338284   6 LYHNTSLCDGCg--LCQLVCALEHcgq----------------wnhYQSRIKIIndme-------------reaFYAVCC 54
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###     #   ##      ##                  #              ####   ### ##            
1KQG_B       101 MHCed-pgCLKACPs---aGAIIQYa-----------nGIVDFQSEnc-----igCGYCIAGCPFNIPRLNke------- 153
gi 913268218  56 IACkderaCAEACPs----GALEKRp-----------gGGVVLKKDkc-----igCKKCVDACIVSAVHFDdd------- 108
gi 931454784  62 RKCee-phCINACPv----DALEQQkd----------kGKLLIRHNmrc----isCKSCSHACPYGTIYPEnv------- 115
gi 951282795 107 TLCm---eCTKVCPt----GALIEIpkdk------vrmGIALIDFSiclgwngdvCLSCSKACPLGARVFEfynsewgnq 173
gi 389401301  73 FFCk---rCEAACSsgvkiTDIMLDlrrdlvelgyngpGTTSITARsc-----arCLQCVRACPHDAREFVdgeg----i 140
gi 694166984  60 KHCkk-akCIEACPe----GALYQDk-----------rGMVLLDWDkc-----tgCGACEEACPFHAIRVTa-------- 110
gi 11095245  101 KHCkr-akCIEAYPq----GALFYDe-----------eGRVVCSEEkc-----tgCGLCEKACPFHAIRVId-------- 151
gi 599129005  51 SQCg---eCIDICPv----QAIYRDa-----------nGVVRINKKdc-----vgCFMCVGFCPEGAMFMHpd------- 100
gi 931520160  46 RHCee-apCVNSCYh----NALEKAa-----------dGHIKRYKMrc-----tsCKSCTVACPFGVIFQDfi------- 97
gi 114338284  55 TQCee-apCILTCLm----NTIYKQp------------GSDITVRDlyh---cigCRACELACPFDAAVFDvi------- 107
                        170       180       190
                 ....*....|....*....|....*....|....*.
Feature 1           # #####           #   #      #   
1KQG_B       154 dnRVYKCTLCvdrvsvgqepACVKTCpt--gAIHFG 187
gi 913268218 109 ehKPIICKHCg---------VCAKFCph--eCLRME 133
gi 931454784 116 plLIHNCDFCldrrdeenepLCIKTCpy--gALRLV 149
gi 951282795 174 pyINENCVGCg---------YCVKFCpvggsAIKVV 200
gi 389401301 141 vvDPVKCQSCg---------ICVEICpi--eAITIP 165
gi 694166984 111 --KCIKCDLCkdvs---dvpACVMYCpt--gALTYK 139
gi 11095245  152 --RCVKCDLCkdvs---dfpVCVTSCpv--gALTVK 180
gi 599129005 101 yiEPFKCVACg---------QCVKVCpt--gTIEII 125
gi 931520160  98 pyLDSHCDYCvgls--kelpRCVSSCpe--kAIEVK 129
gi 114338284 108 keKVVNCDLCgg------rpLCVEYCpk--qALTYD 135

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