Conserved Protein Domain Family
TUDOR

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cd04508: TUDOR 
Click on image for an interactive view with Cn3D
Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to symmetrically dimethylated arginines of arginine-glycine (RG) rich sequences found in the C-terminal tails of Sm proteins. The SMN protein is linked to spinal muscular atrophy. Another example is the tandem tudor domains of 53BP1, which bind to histone H4 specifically dimethylated at Lys20 (H4-K20me2). 53BP1 is a key transducer of the DNA damage checkpoint signal.
Statistics
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PSSM-Id: 119391
View PSSM: cd04508
Aligned: 348 rows
Threshold Bit Score: 31.7996
Threshold Setting Gi: 99032485
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
dimethylated
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:dimethylated arginine/lysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
Feature 1                #    # #                      #  #             
2DIQ_A         36 GDIVAAPLptngSWYRARVLGTle----nGNLDLYFVDfGDNGd--CPLkDLRA 83
2IG0_A          8 GLRVVAKWssngYFYSGKITRDvg----aGKYKLLFDD-GYECd--VLGkDILL 54
gi 118344046  124 NALIDAQDtdvgAWFEAKVVNVtkgktdgLDYHIKFDDyGDDGvkvVGEkLIRP 177
gi 30678010   106 GTKVQAVFsddgEWYDATIEAHt-----aNGYFVAYDEwGNKEe--VDPdNVRP 152
gi 111065008  117 GDLIEAQWtd-rSWYKAKIQSVlgs-asaPKYVVRFIDyDDSTt--VDRdAIRP 166
gi 168021249  115 GTKVQAIWsedgEWYKATVEAVt-----pGGYFVLYDEwGNKEe--VDAsNVRE 161
gi 115928208 1191 GEICGALLvregVWCRGKIQCMlp----dNNAVVLFTDyGNEEv--VSIaNIRA 1238
gi 124422062  167 GQQCEAIYssdgRYYLGTIEKVt-----eEGYHIRFKKnSNREi--VPLiYLRE 213
gi 89291677   179 GFACEAIYpddgKYYPCIIEKIte----dGRYVIKFKKyNNKEe--LSIyLLRE 226
gi 124505129  161 NNQFQALYkkdgQWYDCIISKYk-----gDSFLITYIGyNNSEy--VSTdQVRI 207

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