1EWK,1DP4,1QNL,1QO0,1YK0,1YK1,1Z15,2E4U,2E4Z,2H4A,2LIV,2QH8


Conserved Protein Domain Family
PBP1_ABC_transporter_GCPR_C_like

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cd04509: PBP1_ABC_transporter_GCPR_C_like 
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Family C of G-protein coupled receptors and their close homologs, the type I periplasmic-binding proteins of ATP-binding cassette transporter-like systems
This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type I periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, phermone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine-binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus - which is included in this CD - followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type II periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.
Statistics
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PSSM-Id: 107261
View PSSM: cd04509
Aligned: 62 rows
Threshold Bit Score: 72.1407
Threshold Setting Gi: 157835931
Created: 13-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EWK_A        14 IIGALFsvhhqppaekvperkcgeireqYGIQRVEAMFHTLdkinadp---------vllpnitLGSEIRDscw-----h 79
1DP4_A         4 TVAVVLpltnt-------------sypwSWARVGPAVELALarvkarp---------dllpgwtVRMVLGSsenaagvcs 61
1YK0_A        54 EVLVLLpqdd--------------sylfSLTRVRPAIEYALrsvegngtg-----rrllppgtrFQVAYEDsdc------ 108
1YK1_A        53 EVLVLLpqdd--------------sylfSLTRVRPAIEYALrsvegngtg-----rrllppgtrFQVAYEDsdc------ 107
gi 113916     26 TLAVVLpehnl-------------syawAWPRVGPAVALAVealg---------------ralpVDLRFVSseleg-acs 76
gi 1706243    54 KIGVVGpwac--------------dslfSKALPEVAARLAIerinrdp---------sfdlsysFEYVILNedc-----q 105
gi 2506471    36 EISVLMmnns--------------afpeSLDNLKAVVNEGVnivrqrlleagltvtvnatfvysEGVIYKSsdcrs-stc 100
gi 21430570   31 KIGGLFhpad---------------dhqELAFRQAVDRINAdrsil--------------prskLVAQIERis------- 74
gi 24581733   18 LWIVFInev-----------------dnEPAAKAVEVVLTYlkkn---------------irygLSVQLDSiea-----n 60
gi 76363518   47 TVGFHApwni--------------shpfSVQRLGAGLQIAVdklnsep---------vgpgnlsWEFTYTNatc-----n 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EWK_A        80 ssVALEQSIEFIRdslisirdekdglnrclpdgqtlppgrtkkpIAGVIGpgsssvai-qvqnllqlFDIPQIAYSAtsi 158
1DP4_A        62 dtAAPLAAVDLKWeh----------------------------sPAVFLGpgcvysaa-pvgrftahWRVPLLTAGApal 112
1YK0_A       109 gnRALFSLVDRVAaar-------------------------gakPDLILGpvceyaaa-pvarlashWDLPMLSAGAlaa 162
1YK1_A       108 gnRALFSLVDRVAaar-------------------------gakPDLILGpvceyaaa-pvarlashWDLPMLSAGAlaa 161
gi 113916     77 eyLAPLSAVDLKLyh----------------------------dPDLLLGpgcvypaa-svarfashWRLPLLTAGAvas 127
gi 1706243   106 tsRALSSFISHHQm------------------------------ASGFIGptnpgyce-aasllgnsWDKGIFSWACvny 154
gi 2506471   101 egLDLLRTISSEKr-----------------------------mGCVLLGpsctystf--qmyldtdLNYPMISAGSfgl 149
gi 21430570   75 pfDSFHAGKRVCGlln--------------------------igVAAIFGpqsshtas-hvqsicdnMEIPHLENRWdyr 127
gi 24581733   61 ksDAKVLLEAICNkyatsi--------------------ekkqtPHLILDttksgiasetvksftqaLGLPTISASYgqq 120
gi 76363518   99 akESLAAFIDQVQre----------------------------hISVLIGpacpeaae-vigllaseWDIPLFDFVGqmt 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EWK_A       159 dlsdk------tlykyflRVVPSDtlQARAMLDIVKryn--------wtYVSAVHTEGn-----yGESGMDAFKELaaqe 219
1DP4_A       113 gigvk------deyalttRTGPSHvkLGDFVTALHRrlg-------wehQALVLYADRlgd-drpCFFIVEGLYMRvrer 178
1YK0_A       163 gfqhk-----dseyshltRVAPAYakMGEMMLALFRhhh--------wsRAALVYSDDkle--rnCYFTLEGVHEVfqee 227
1YK1_A       162 gfqhk-----dseyshltRVAPAYakMGEMMLALFRhhh--------wsRAALVYSDDkle--rnCYFTLEGVHEVfqee 226
gi 113916    128 gfsak-----ndhyrtlvRTGPSApkLGEFVVTLHGhfn-------wtaRAALLYLDArtd-drpHYFTIEGVFEAlqgs 194
gi 1706243   155 eldnk------isyptfsRTLPSPirVLVTVMKYFQwa----------hAGVISSDEDi------WVHTANRVASAlrsh 212
gi 2506471   150 scd---------yketltRLMSPArkLMYFLVDFWKvnnfpfkpfswntAYVFKNSTEse----dCFWYLNALEAGvsyf 216
gi 21430570  128 lrr----------esclvNLYPHPntLSKAYVDIVRhwg--------wkTFTIIYENNd-----gIVRLQELLKAHgmtp 184
gi 24581733  121 gdlrqwrdldeakqkyllQVMPPAdiIPEAIRSIVIhmn--------itNAAILYDDSfvmdhkyKSLLQNIQTRHvita 192
gi 76363518  150 aledh------fwcdtcvTLVPPKqeIGTVLRESLQylg-------weyIGVFGGSSAgs----sWGEVNELWKAVedel 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EWK_A       220 g-lciaHSDKIysnag--eksfDRLLRKLRErlpkarVVVCFceg-----mtVRGLLSAMRRLgvv--geFSLIGSdgwa 289
1DP4_A       179 l-nitvNHQEFvegd---pdhyPKLLRAVRRkg---rVIYICssp-----daFRNLMLLALNAglt-gedYVFFHLdvfg 245
1YK0_A       228 --glhtSIYSFdetk---dldlEDIVRNIQAse---rVVIMCass-----dtIRSIMLVAHRHgmt-sgdYAFFNIelfn 293
1YK1_A       227 --glhtSIYSFdetk---dldlEDIVRNIQAse---rVVIMCass-----dtIRSIMLVAHRHgmt-sgdYAFFNIelfn 292
gi 113916    195 --nlsvQHQVYarep----ggpEQATHFIRAng---rIVYICgpl-----emLHEILLQAQREnlt-ngdYVFFYLdvfg 259
gi 1706243   213 --glpvGVVLTtgqdsqsmrkaLQRIHQADRi----rIIIMCmhsaliggetQMHLLECAHDLkmt-dgtYVFVPYdall 285
gi 2506471   217 --sqklSFKEMlrgn----eefQNILMDQNRks---nVIIMCgap-----etVHTLKGGRAVAe-----dTVIILVdlfn 277
gi 21430570  185 fpitvrQLSDSgd--------yRPLLKQIKNsae-ahIVLDCst------erIHEVLKQAQQIgmm-sdyHSYLVTsldl 248
gi 24581733  193 ---iakDGKREr---------eEQIEKLRNLdi--nnFFILGtl------qsIRMVLESVKPAyfernfaWHAITQnege 252
gi 76363518  213 --qlhfTITARvryssghsdllQEGLRSMSSva--rvIILICss------edAKHILQAAEDLgln-sgeFVFLLLqqle 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EWK_A       290 drdevi------------------egyeveangGITIKLqspevrsfddyflklrldtntrnpwfpefwqhrfqcrlpgh 351
1DP4_A       246 qslksaqglvpqkp--wergdgqdrsarqafqaAKIITYkepdnpeyleflkqlkl------------------------ 299
1YK0_A       294 sssygdgswkr--------gdkhdfeakqayssLQTVTLlrtvkpefekfsmevk------------------------- 340
1YK1_A       293 sssygdgswkr--------gdkhdfeakqayssLQTVTLlrtvkpefekfsmevk------------------------- 339
gi 113916    260 eslragptratgrpwqdnrtreqaqalreafqtVLVITYreppnpeyqefqnrlli------------------------ 315
gi 1706243   286 yslpykhtpyq--------vlrnnpklreaydaVLTITVesqektfyqafteaaa------------------------- 332
gi 2506471   278 dhyfmd-----------------nvtapdymknVLVLTLppensvsnssf------------------------------ 310
gi 21430570  249 htvnl--------------------defryggtNITGFRlinekivsdvvrqwsi------------------------- 283
gi 24581733  253 i---------------------------ssqrdNATIMFmkpmaytqyrdrlg--------------------------- 278
gi 76363518  282 dsfwkevla-----------edkvtrfpkvyesVFLIAPstyggsagdddfrkqvyqr---------------------- 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1EWK_A       352 llenpnfkkvctgnesleenyvqdsKMGFVINAIYAmahglqnmhhalcpghvglcdamkpid-----------grklld 420
1DP4_A       300 --------ladkkfnftvedglkniIPASFHDGLLLyvqavtetlaqggtvtdgenit---------------------- 349
1YK0_A       341 ---------ssvekqglnmedyvnmFVEGFHDAILLyvlalhevlragyskkdggkii---------------------- 389
1YK1_A       340 ---------ssvekqglnmedyvnmFVEGFHDAILLyvlalhevlragyskkdggkii---------------------- 388
gi 113916    316 --------raredfgvelgpslmnlIAGCFYDGILLyaevlnetiqeggtredglriv---------------------- 365
gi 1706243   333 ----------rgeipeklefdqvspLFGTIYNSIYFiaqamnnamkengqagaaslv----------------------- 379
gi 2506471   311 ---------------skdlslvkndFTLAYMNGVLLfghmlkiflekredvttskfa----------------------- 352
gi 21430570  284 ---------dekgllrsanlttvrsETALMYDAVHLfakalhdldtsqqidihpiscdgqstw-----------qhgfsl 343
gi 24581733  279 -----------llrttynlneepqlSSAFYFDLALRsfltikemlqsgawpkdmeylncddfqggntpqrnldlrdyftk 347
gi 76363518  329 -------lrrppfqssissedqvspYSAYLHDALLLyaqtveemmkaekdfrdgrqlis--------------------t 381
                        490       500       510
                 ....*....|....*....|....*....|.
1EWK_A       421 flikssfvgvsgeevwfdekgDAPg-rYDIM 450
1DP4_A       350 qrmwnrsfqgvtgylkidrngDRDt-dFSLW 379
1YK0_A       390 qqtwnrtfegiagqvsidangDRYg-dFSVI 419
1YK1_A       389 qqtwnrtfegiagqvsidangDRYg-dFSVI 418
gi 113916    366 ekmqgrryhgvtglvvmdknnDREt-dFVLW 395
gi 1706243   380 qhsrnmqfhgfnqlmrtdsngNGIs-eYVIL 409
gi 2506471   353 hafrnitfeghmgpvtldncgDIDn-tMFLL 382
gi 21430570  344 inymkivemkgltnvikfdhqGFRa-dFMLD 373
gi 24581733  348 iteptsygtfdlvtqstqpfnGHSfmkFEMD 378
gi 76363518  382 lradqvtlqgitgpvlldaqgKRHm-dYSVY 411
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