Conserved Protein Domain Family
LbH_Dynactin_6

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cd04646: LbH_Dynactin_6 
Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping protein Arp1, and dynamatin. In vitro binding experiments show that dynactin enhances dynein-dependent motility, possibly through interaction with microtubules and vesicles. Subunit p27 is part of the pointed-end subcomplex in dynactin that also includes p25, p26, and Arp11. This subcomplex interacts with membranous cargoes. p25 and p27 contain the imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), indicating a left-handed parallel beta helix (LbH) structural domain. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100052
View PSSM: cd04646
Aligned: 15 rows
Threshold Bit Score: 151.324
Threshold Setting Gi: 67609389
Created: 24-Jul-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024856    10 KIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAypdnitpdtedpepkPMIIGTNNV 89
gi 73853353    8 KILPKAVVCEESSLRGDITFSSGCVVHPSATVIADAGPIIIGENCIIEEYATVAHRlepgav----wdvnnILSIGTHNV 83
gi 56753784   15 HITPGAVVCSECELSGEIIIGANTIIHPRARIIAEAGPIHIGSFNLIEEQVEIVNKip-----------gfTMKIGDHNV 83
gi 58263272   29 TAHATSLICADTDLRGPISVGPNVIIHPRATIYAAAGPIMLGEGCIVEEGCIIVNRkk------------dTMKIGENNH 96
gi 89308974  254 QKTTATILSQKSEILGNVKFGKGCIIHPNCTILAEGGDIIFGDYNIIEERVSIVNKkskdp------aknkNMFIGSYNL 327
gi 71995484    8 SIASSAIVCVEADIKGEVIIKEGCVVHPFVVFDATKGPIYVGENNIFEEYAVIRNNsd-----------gqPMIIGDWNI 76
gi 115894428  14 KIGAGAVVCVEAELRGDITIGPRTVIHPRARIIAEAGPIVIGESNLVEDQVVIINRkqlgq------egpiTMTIGANNV 87
gi 156372557  12 KIGAGSVVCQEAEIKGEVIIGSKTVVHPKARIIAEAGPIIIGDNNLIEEQVTIINPlqveene-evpperiVMHIGCNNV 90
gi 91085839    7 KILPGALVCEESKLRGDITIGAGTIIHPSATILAEAGPIIIGDCCLIEEQAKIIHRlpfdeq---dtektpVLIIGAHNV 83
gi 156546602 402 KVGVGAIVCEEAILKGDICIGSRTVVHPRASIIAEAGPIIIGEGNIIEEMVTITNRissdp------svtpVQIIGNYNV 475
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024856    90 FEVGCYSQA-------------------MKMGDNNVIESKAYVGrnVILTSGCIIGACCNLNtf--------eVIPENTV 142
gi 73853353   84 FEVGCQVEA-------------------AKIGDKNVFESKCYVGpgVTVSSGCVVGAGIKIHgs--------qRLPENTI 136
gi 56753784   84 FEVGAHCYA-------------------LEIGDNNVFEAKCYIGsnMKITHGCVIGAMCSMDsc--------eILPECTV 136
gi 58263272   97 FMVGCRTFYpfdliyldnnligragiesPSIGNNNIFQPKSTASggVIVTDNCIISAGTILLpsptgtdqepeTLPPYTV 176
gi 89308974  328 FEVGSKIDT-------------------SDIGNMNHFEPRSSVEqdCQIKDKCTIGACVKLPqg--------tIIEDKKI 380
gi 71995484   77 FQVHSKSSA-------------------KYVGSRNVIGVHAVLEdgCSVSDDCSVGAKCTVFsh--------qNLEPSVS 129
gi 115894428  88 FEVGSRCEA-------------------VRVGNNNVVESKAFIGrdTEMSNGCVIGAFCNITsh--------eRLPEHTV 140
gi 156372557  91 FEVGSLCEA-------------------VKIGDNNILEAKSRVGrqTVLSHGCVIGARCEVTsq--------eTIPENTV 143
gi 91085839   84 FEVDCHVES-------------------PKIGNCNVFESKCFVGnkVTVTNGCTVGAGCKVTee--------qILKENVI 136
gi 156546602 476 FEVDSTCEA-------------------SKVGDNNILESKAFVSkeVELTSGCIIGTGCSLTeq--------eTVPENTI 528
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 3024856   143 IYGADCLRRvqterp-----qpqtlQLDFLMKILPNYHHLKK 179
gi 73853353  137 VYGEQGLQReaidkq-----gsqtlQIDFLRKVLPNYHHLRK 173
gi 56753784  137 VYGEECHRRiaterp-----aaqtlQLDFLTKILPNYHHLMK 173
gi 58263272  177 IYGADSSRRtwdgsghvaemalrskQAEYLREIMPKYVYNDV 218
gi 89308974  381 YYPDKVVKElnfdeqr--fqkhivsMYQALSILIPQNNPVKQ 420
gi 71995484  130 VYAATNLSRttktpn-----mtsphQIEFLRKILPSYHHLYG 166
gi 115894428 141 IFGDECRRRlqadkp-----qaqtlQLDFLMKILPNYHHLKK 177
gi 156372557 144 IYGQSCNRRvqaerp-----vpqslQLDFLTKILPNYHHMKK 180
gi 91085839  137 IFGEKCQMRegldrp-----glqtlQMETLSKVLPNYHHIRK 173
gi 156546602 529 IYGNQCQRRemndkp-----ypqigQLDYLMKILPNYHHIYK 565
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