Conserved Protein Domain Family
LbH_THP_succinylT_putative

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cd04649: LbH_THP_succinylT_putative 
Click on image for an interactive view with Cn3D
Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal domain of unknown function and a C-terminal LbH domain with similarity to THP succinyltransferase LbH. THP succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA. It is the committed step in the succinylase pathway by which bacteria synthesize L-lysine and meso-diaminopimelate, a component of peptidoglycan. The enzyme is trimeric and displays the left-handed parallel alpha-helix (LbH) structural motif encoded by the hexapeptide repeat motif.
Statistics
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PSSM-Id: 100054
View PSSM: cd04649
Aligned: 10 rows
Threshold Bit Score: 199.947
Threshold Setting Gi: 46205004
Created: 10-Oct-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative trimerputative CoA
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the trimer structures of some members of the superfamily including E. coli Maltose O-acetyltransferase, Chlamydia Trachomatis Lpxd, and E. coli serine acetyltransferase.
  • Comment:Most characterized members of the LbH superfamily form trimeric structures in their active form. However, there are a few members that form different quaternary structures such as Glucose-1-phosphate adenylyltransferase which forms a tetramer. Hence, not all members may form trimers.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                # # # #         #     # #               
2RIJ_A       217 NTRILESSKVRXGASLAa-GTTIXPgaSYVNFNAGTTGACXVEGRISSSAIVGEGSDVGGGASILGVLSGTsgNAISVGK 295
gi 107836807 227 NIRLLDSSKTRFGAYLGtgGYTQMPgaSYVNFNAGAMGVCMNEGRISSSVIVGAGTDIGGGASVLGVLSGGnnNPISIGK 306
gi 9949828   181 GVRIADTARVRLGAYIGe-GTTVMHe-GFVNFNAGTEGPGMIEGRVSAGVFVGKGSDLGGGCSTMGTLSGGgnIVISVGE 258
gi 50839719  162 GVRIGDADRVRLGAHLAv-GTTVMHe-GFVNFNAGTLGHSMVEGRISQGVIVGDGTDIGGGASIMGTLSGGgkERVTIGR 239
gi 91222931  164 GVRIADTARVRLGAYLGe-GTTVMHe-GFVNYNAGTEGPNMIEGRISSGVFIGKDTDLGGGSSTMGTLSGGneKIISVGE 241
gi 46205004    9 GVRIADADRVRLGAHLAa-GTTVMHe-GFVNFNAGTLGTSMVEGRISAGVVVGDGSDVGGGASIMGTLSGGgrEVISVGQ 86
gi 91780848  139 GVRVADADRVRLGAYLAs-GTTVMHe-GFVNFNAGTLGESMVEGRVTPGVVVGKNSDVGAGSSIMGTLSGGgkSKNSIGE 216
gi 116334920 160 NVRISNTNRVRLGAYLCs-GTTIMSe-GYVNFNTFIGKNCMIEGRVSSGVSVFNNTDIGGSSSIMGTLSGGgnNIISIGD 237
gi 149195883 184 GVRIGNGAKIRLGAHLGe-GTTVMQa-GFVNFNAGTEGNAMIEGRVSAGVFVSKDSDVGGGASIMGTLSGGgkEVVCIGS 261
gi 13880830  159 GVRIADADRVRLGAHLAp-GTTVMHe-GFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMGTLSGGgtHVISIGK 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #    ## #       #   # # #                                                     
2RIJ_A       296 ACLLGANSVTGIPLGDNCIVDAGIAVLEGTKFLlkdaeelakl---npyfnfdkeiYKGLELKGLngLHFRQDSISGAXI 372
gi 107836807 307 NCLLGANSVTGISLGDGCIVDAGVTILAGSVIEieenefkkllevnsalekhannlYKGKELSGKngVHFRSNSQNGKLI 386
gi 9949828   259 GCLIGANAGIGIPLGDRNIVEAGLYITAGTKVAlldeqn------------alvkvVKARDLAGQpdLLFRRNSQNGAVE 326
gi 50839719  240 GCLLGAEAGIGISLGDNCVVEAGLYVTAGTKVTlpn-----------------gkvVKASELSGAsdILYIRDSTTGIVK 302
gi 91222931  242 RCLLGANSGIGISLGNDCTVEAGLYLTAGTKVTlvdn---------------eekiVKALELSGKdgILYYRDSLSGKVC 306
gi 46205004   87 RSLLGANAGLGIPLGDDCVVESGLYVTAGTKVTvvgqrda----------sgeplvVKARDLAGRsgILFRRNSLTGGVE 156
gi 91780848  217 RSLLGANAGIGISLGDECIVEAGLYVTAGTKVKlpd-----------------gtiLAARELSGRhgLLFRRNSQTGAVE 279
gi 116334920 238 KCLLGANSGIGISLGNNCIVEAGLYITSGTKIFflfnn--------------kkilIKANKLSFKnnIIFFRNSVNGKVE 303
gi 149195883 262 KCLLGANAGTGISLGFGCTVGAGTYITASSKVSlydensnpvnl-ngdlvaegenvVKGLDLSGRdkLLIYQDSVSGKLI 340
gi 13880830  237 RCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTmpd-----------------snsVKARELSGSsnLLFRRNSVSGAVE 299

                 .
Feature 1         
2RIJ_A       373 V 373
gi 107836807 387 A 387
gi 9949828   327 C 327
gi 50839719  303 A 303
gi 91222931  307 A 307
gi 46205004  157 A 157
gi 91780848  280 V 280
gi 116334920 304 C 304
gi 149195883 341 C 341
gi 13880830  300 V 300

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