1YP4,1YP2


Conserved Protein Domain Family
LbH_G1P_AT_C

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cd04651: LbH_G1P_AT_C 
Click on image for an interactive view with Cn3D
Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-limiting step in starch biosynthesis in plants and glycogen biosynthesis in bacteria. It is the enzymatic site for regulation of storage polysaccharide accumulation in plants and bacteria. The enzyme is a homotetramer, with each subunit containing an N-terminal catalytic domain that resembles a dinucleotide-binding Rossmann fold and a C-terminal LbH fold domain with at 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). The LbH domain is involved in cooperative allosteric regulation and oligomerization.
Statistics
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PSSM-Id: 100056
View PSSM: cd04651
Aligned: 121 rows
Threshold Bit Score: 82.5113
Threshold Setting Gi: 58254321
Created: 12-Oct-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfacesulfate 1N-terminal
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Glc-1-phosphate adenylyltransferase or ADP-Glc pyrophosphorylase forms a homotetramer (a dimer of homodimers). One dimer interface is made almost exclusively by end-to-end stacking between the C-terminal LbH domains of two monomers. The dimer of dimers interface is formed by contacts between N-terminal Rossmann fold domains.
  • Structure:1YP4_CD; Interface between monomers in Solanum tuberosum ADP-Glc pyrophosphorylase homodimer; defined at 3.5A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # #############                                                                 
1YP4_D       319 PPSKMLDADVTDSVIGEGCVIknCKIHHSVVGLRSCISEgAIIEdSLLMGAdyyetdadrkllaakgsvpiGIGKNCHIK 398 potato
AAT82396     302 GAKFVMRGSCDDTLVSAGCIIsgTDIYRTVLGPRARIERwARVDeSIVMNNv-------------------AIGSNATVH 362 Propionibacteri...
NP_696043    308 HAGRDRLGHATDSIVSPGVIVsgGEVHHSVLSPNVRIHSwAQIVdSVLFDGv-------------------VINRRARVY 368 Bifidobacterium...
YP_001362629 309 HGWQGTYGHAVNSIVSQGTVVsgALVEKSVVSPNVRLDSwAHVSeSVLMDGv-------------------QVGRHAVVQ 369 Kineococcus rad...
ZP_00209253   82 HAGRGRLGHAADSIVSPGVIIsgATAVGSVLSPGTYLHSwSSVSdSVLMDGv-------------------QVHRHAQVH 142 Magnetospirillu...
Q6AF21       308 RDGRGALGTTIDSIVSLGSVIsgAHLERSVLGPWATVDSgAKVIdSVVFERa-------------------LIEPNAFVG 368 Leifsonia xyli ...
YP_873579    309 AKIVHDGTSVVDSLLSDGVIVadARVSRSVLSPSVYVDRgAVIEgCVLLDNv-------------------HIGRGAVVR 369 Acidothermus ce...
P72394       296 PARFNAGGIASESIISAGCLIr-GQVTRSVLSPGVVVDPgAVVQgSVLHDNv-------------------HIGRGAVVR 355 Streptomyces co...
Q8FQE4       306 PAKFVQGGIAQSSMVAPGSIIsaGTVRNSVLSTDVIVEEgATVEgAVLMPGv-------------------RIGKGAVVR 366 Corynebacterium...
CAI10070     300 EAAQVHDGHIRTASLGAGVVIrrAVIERSLLRREVVVEEgAEVVdSIIMDRs-------------------VIGKGARVR 360 Azoarcus sp. EbN1
Feature 1                                                       
1YP4_D       399 RAIIDKNARIGDNVKIInkdnvqeaaretdgyfiksgIVTVIKDALI 445 potato
AAT82396     363 RAILDKNVIVPDGAQVGvdhdhdrar---gftvspggVTVVGKGITV 406 Propionibacterium acnes KPA171202
NP_696043    369 KAILDKNVVLTENSTVGidtehdlar---gftvtpdgITVVPKNTIV 412 Bifidobacterium longum NCC2705
YP_001362629 370 RAIVDKFVTVPDDARIGvdpeedrar---gfhvtdsgITVVGKGQTI 413 Kineococcus radiotolerans SRS30216
ZP_00209253  143 RAIIDKNVVVGEQARIGldpeqdrar---gftvtesgITVVPKGTVV 186 Magnetospirillum magnetotacticum MS-1
Q6AF21       369 RAILDKDVVVAAGASIGvdpdrdrar---gftvtesgITVVGKGVHV 412 Leifsonia xyli subsp. xyli
YP_873579    370 NAIIDKNVVVPDGAAIGvdpqrdae----rftvseggIVVIAKNAVV 412 Acidothermus cellulolyticus 11B
P72394       356 GAVLDKNVQVPPGATIGvnpqrdge----lytvskggVIALGKGQRV 398 Streptomyces coelicolor
Q8FQE4       367 HAILDKNVVVRDGELIGvdhdrdsq----rfkvsaggVVTVGKNQVV 409 Corynebacterium efficiens
CAI10070     361 RAIIDQYNFVPPGMKIGydpeadrq----rfhisesgVVVVGKGQLK 403 Azoarcus sp. EbN1

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