Conserved Protein Domain Family
LbH_eIF2B_gamma_C

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cd04652: LbH_eIF2B_gamma_C 
eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is important for regenerating GTP-bound eIF2 during the initiation process. This event is obligatory for eIF2 to bind initiator methionyl-tRNA, forming the ternary initiation complex. The eIF-2B gamma subunit contains an N-terminal domain that resembles a dinucleotide-binding Rossmann fold and a C-terminal LbH domain with 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). The epsilon and gamma subunits form the catalytic subcomplex of eIF-2B, which binds eIF2 and catalyzes guanine nucleotide exchange.
Statistics
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PSSM-Id: 100057
View PSSM: cd04652
Aligned: 27 rows
Threshold Bit Score: 101.885
Threshold Setting Gi: 76157257
Created: 12-Oct-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203317  357 LIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNnAVIEKgADIKDCLIGSGQRIEAKA 436
gi 54291224  362 MLAEGSQLGDKCSVKRSVIGRHCRIGSNVKIVNSVVMNHVVIEDGCHIQGSVICNnVQLQErAVLKDCQVGAGYIVTASS 441
gi 79328173  367 MLGEGSQVGDKCSVKRSVIGRHCRIGSNVKIVNSVVMDHATIGDGCSIQGSVICSnAQLQErVTLRDCQVEAGYVVCAGS 446
gi 156382601 351 MVDASVSIGDKVSVKRSVIGKHTTIGDKVKISNSVIMDHVTIKDGCNITSSIVCNnAYIKEnASLKDCQVGNSHTIGEGG 430
gi 89286578  349 NIADKSQIGPKVQINKSIIGPQCKIGDGVKISNCIIFKEVTIEQGCVLQNCIIGNkATIKQnSKLNDCQIGVNGVVEANS 428
gi 57229191  451 VLGEGTRVGEKTSIKKCIIGRHCVIGKGAKLNNCVIWDFVTVEENARIENSIICSnGRIGEkAQVKDCEFGTGFEAKPGA 530
gi 3023677   371 MVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASgAQIGAkSKLRECEIGVDHRVEAGR 450
gi 24653885  357 IAADNAKLSEKTSLNFSVFGPNCIISPKNIVANSLIMSNAIVEEGCNIDNCIIGHrAQVKSgSVLKNCIIGPNYVVEEGT 436
gi 108872256 359 AVGDQTVVSEKTSINSSIIGANCVINPKVRLTNCTLMDHVIIEESVTMENCIVCEkSVIKSgSSLRNSLIGSNYIVSANT 438
gi 91090558  358 VVWEGAKLHEKTSFKNSVIGANSEVCSFSRVFNCIVMNNVTIKEKVALENCIVSDgVTIEKgCQIKGCLIGSHHLVPENS 437

                 .
gi 18203317  437 K 437
gi 54291224  442 E 442
gi 79328173  447 E 447
gi 156382601 431 E 431
gi 89286578  429 S 429
gi 57229191  531 I 531
gi 3023677   451 I 451
gi 24653885  437 H 437
gi 108872256 439 K 439
gi 91090558  438 E 438
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