Conserved Protein Domain Family
LbH_paaY_like

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cd04745: LbH_paaY_like 
paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to adopt the left-handed parallel beta-helix (LbH) structure. They contain imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Similarity to gamma carbonic anhydrase and Ferripyochelin Binding Protein (FBP) may suggest metal binding capacity.
Statistics
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PSSM-Id: 100058
View PSSM: cd04745
Aligned: 10 rows
Threshold Bit Score: 231.103
Threshold Setting Gi: 91780935
Created: 22-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative metalputative trimer
Feature 1:putative metal binding site [ion binding site]
Evidence:
  • Comment:Based on the active site/zinc binding site of Methanosarcina thermophila gamma carbonic anhydrase (1THJ).
  • Comment:Zinc ions are bound at the interface of neighboring subunits of the trimer. The trimer contains three zinc binding sites.
  • Citation:PMID 8665839

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                #    #   
gi 84501849   12 PVVPEDSYVHPQAVLIGNVILGHGCYIGPGASLRGDFGKIVIGDGANVQDNCIIHSFPgrdaVVETDGHIGHGAILHGCT 91
gi 2764835    11 PVVPEESFVHPTAVLIGDVILGKGVYVGPNASLRGDFGRIVVKDGANIQDNCVMHGFPeqdtVVEEDGHIGHSAILHGCI 90
gi 91780935   13 PEVSGSAFVHPTAVLIGRVTISDHCYIGPHATLRGDGGVILLREGAIVQDSCTIHGRNa---VLEVGSCLGHNAVVHGAR 89
gi 89517392   14 PVIHESSFVHPQATVIGNVIIGKNCYVGPSAVIRGDWGEIILEDGVNVQENCTIHMFPgksiTLKESAHVGHGAIIHGAN 93
gi 118073633  11 PVIEPTSFIHPNATIIGDVIIGKHCYIGSNACLRGDFGRIEIHDFCNVQDNCVLHSFPlqacVLEEYSHIGHGAILHGCT 90
gi 46201895   13 PVVDPTSYVHPTAVLIGDVRIGPGCFIGPGASLRADFSSVIIGAGVNIQDNCILHGTPgfhtVVEDYGHIGHAAVVHGCR 92
gi 119944434  11 PVIHPSSFVHPSADIIGDVIIGKNVYIGPQVAVRGDMGGIRIMDGSNIQDNCVIHGFPdyetLLEENSHIGHGAIIHGCH 90
gi 110599035  20 PVIDPTSFVHPDAVIIGDVIIGPNSYIGACACLRGDLGRIVISAGANIQDTCVIHSFPevdvIVGENGHVGHGAILHGCT 99
gi 78062317   11 PRVDPSAYVDPSAVVIGDVTIGARCYIGPHASLRGDFGAIVVEDGSNVQDGCVLHVGIgetcRLGVNSHIGHGAIVHGAT 90
gi 10635040   11 PVVHPSAYVHPDAVLVGDVHIGARCYVAPLASLRGDFGPIILREGANVQDCCVMHGFPgidtLVEENGHVGHGAILHSCH 90
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                                                   
gi 84501849   92 VGRnALVGMNAVIMDGVELGAESIVGAQAFVRGETVIRPRSMVVGSPAKVIREVSEkEVAWKTRGTAEYQQLARD 166
gi 2764835    91 IRRnALVGMNAVVMDGAVIGENSIVGASAFVKAKAEMPANYLIVGSPAKAIRELSEqELAWKKQGTHEYQVLVTR 165
gi 91780935   90 IGEgALVGISSVVLDEAVVGSQAILGALSLLTARTLLPDRHLATGIPAKVLRALSGnEVSRMVEGGKHYEALTML 164
gi 89517392   94 LGRnCMIGMNSVIMDDATIGDECIVGAMAFVKAEAVFEPRSLIVGNPAKKIKEVSDqMIEWKTAGTKLYQQLPAD 168
gi 118073633  91 IRRhSLVGINAVVMDFADIGAESIIGAASFVKSRFNCPARSMLLGSPAKIVRQVSDeEFQWKTRGTDEYIELTRR 165
gi 46201895   93 IRRnALVGMASSIYDGAEVGEEAIIAAMAFVPAGFKIPPRTLVAGLPAKVLRELSDeEVARKTRGTEAYQQLAQR 167
gi 119944434  91 IEEnCLIGMNAVVMDLSVIGKESIVGAHSFIKANSHFDARSLILGSPATVKRTVSDdELTWKIKGTVMYHELVER 165
gi 110599035 100 IGRnALIGMNAVVMDHAVIGENSFVAAMAFVKSGMTTGANMLIGGMPAREIRPLEKeEITRKAQGTLLYQWLAAQ 174
gi 78062317   91 LEPdTMIGMNAVVMDSATIGATTIVAACAFVKAGYDVPRGVLLAGMPGRVVRRLSDaEIDAKANGTRIYQQLAAD 165
gi 10635040   91 VGRnALVGMNAVVMDRAVIGESSIVAACSFVKAGMEIPPQVLVAGVPAKVVRTLTRqEMDWKVEGTRCYHDLAAR 165

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