Conserved Protein Domain Family
HTH_HspR

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cd04766: HTH_HspR 
Helix-Turn-Helix DNA binding domain of the HspR transcription regulator
Helix-turn-helix (HTH) transcription regulator HspR, N-terminal domain. Heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.
Statistics
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PSSM-Id: 133394
View PSSM: cd04766
Aligned: 18 rows
Threshold Bit Score: 113.514
Threshold Setting Gi: 111020554
Created: 26-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ###             #                         ###                                 
gi 2094832    12 TFLISVAAELAGMHAQTLRTYDRLGLVSPRRTSG----------GGRRYSlHDVELLRQVQHLSQdEGVNLAGIKRIIEl 81
gi 28493714    6 FFTVTVAAALSGMHPQTLRKLDRLGLLSPKRTLG----------GDRRYTaQDVEGLRAISSMVS-SGLTLEGIKHIAR- 73
gi 111020554  17 VYSISVAAELSGFGIAALRLYEEYGLITPLRTGG----------GTRRYSdHDLARLERVAELID-SGVNLVGIGRVLDl 85
gi 111223436  12 VYGISVAADLVGMDPQSLRAYERRGLLDPARTGG----------GTRRYSsDDLARLQRIGHLLA-AGLNLAGIARVLE- 79
gi 35213433   12 VYIISVAAELVGMHPQTLRQYERAGLVHPYRMPGrgegkggkerETRLYSeHDIEQLRYIKRLTQeLKVNLEGVKQIAL- 90
gi 15805958  133 VYVISIAAELVDMHPQTLRLYERKQLIHPGRSSG----------KTRLYSeRDIEHLREIRRLTQeLGVNLAGVEEIMR- 201
gi 108803630   8 VFMIGVAAELIGVHPQTLRMYEQKGLLRPRKSLK----------NTRLYSqEDIELGRYIQRLTQeMGMNLAGVKKILE- 76
gi 2314167     8 LYLISVVAKILGVHPQTLRQYEKEGLIEPSRTDG----------KMRLYSqRDMDKIKTILRLTRdMGVNLAGVDIILR- 76
gi 2983291     7 YYTIGVVAKMYNIHPQTLRLYEREGLLKPSRSEG----------NTRLYTdEDLERLEFILFLTReLGVNLAGVDIILN- 75
gi 106889259   5 YYTIKAAAALCGMHEQSLRLYERRGLIRPQRTPG----------NIRRYSeSDIEQIRFIKRLIDdLGVNLAGVEVILH- 73
                         90       100
                 ....*....|....*....|....*...
Feature 1                                    
gi 2094832    82 tsqveaLQSRLQEMAEELAVLRANQRRE 109
gi 28493714   74 ------LEKELASLKAENHLLRQKLKND 95
gi 111020554  86 ehrtgeLERDNRRLAADNAQLRAEQTPA 113
gi 111223436  80 ------LETENARLRAALELTQAADVKP 101
gi 35213433   91 ------LKEELDLRQRELDKQKQKMQQE 112
gi 15805958  202 ------LRHELDASRAHLEGNVRRLQDD 223
gi 108803630  77 ------LEREIQSLRAENSRLRQEMERR 98
gi 2314167    77 ------LKEKLDELDNLNKELQDALHKH 98
gi 2983291    76 ------LKEQMEQMQKQIDQLMEFIQNE 97
gi 106889259  74 ------LRQQLIEVQRELEELRSRMPVD 95

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