Conserved Protein Domain Family
HTH_TioE_rpt1

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cd04772: HTH_TioE_rpt1 
First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE
Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.
Statistics
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PSSM-Id: 133399
View PSSM: cd04772
Aligned: 9 rows
Threshold Bit Score: 122.886
Threshold Setting Gi: 81681114
Created: 13-Nov-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###             #                ###                                           
gi 81681114    3 FRPADLAHEHGLSPQSVRNYERDGLIPPARRTEsGYRRYTeKHAAALRAYRALIpahGYAESGAIMRDITAgrln-ealT 81
gi 113942088   7 FRTVDLAKAINVSVQQVRNYQAEGFLPNVERGSnGYRQYTqQHIDAIKTAHQLIkgyGWRNAQQIMAALHQanhq-tafN 85
gi 21222864    8 LRTVDLARAVGLSTQQVRNYEDAGVLPPAGRTDaGYRVFGeRHRDALLTYRALQpgyGAVTATRVMRAVHAgdva-galA 86
gi 111017245   9 LRTVDVARRAGCSVQHVRNLERDGVLPPATRTAtGYRIYTdVHVQSALAYRELAigvGPVEATRIVRSVHTcpaa-ttvA 87
gi 113945520   9 YRPVDLARAHGLSAQAVRNYEAAGVIPPARRTAsGYRIYTdDQAAALTAYVALVrgyGFQPAGKIMRLVLRddlp-salA 87
gi 56965537    4 YRPIDIARELNISTSALRHYESWGIIPPPERAAnQYRLYTnEHLAYFRCLRAMIpgfGFPLTAKVLRAVQNgdvd-kafW 82
gi 15896746    4 YRPIELAKMFNLHSNTIRFYESIGYISKASRKPnGYREFTdKHILQLTICRHIL---GYRYTNRHIRDTGKliiicsaeS 80
gi 109645109   4 YKTSEIAHSIGIHPNTVRLYEELELIPKPLRKAnGYRVFTdFHMEQIKLARIAL---KVEVLQNGLRKQAIaiiktsalG 80
gi 90572961    4 YTTSEVADLIGVHPNTVRLYEELNLIPKPKRNTnGYRIFNdFHIEQFRFARTAL---KIEVVQRGLRKDALeivrtsanR 80
                         90       100
                 ....*....|....*....|
Feature 1                            
gi 81681114   82 TIDRSHAELLRDRGTLDAVA 101
gi 113942088  86 LINQHHAKLDSIRQQLDQTL 105
gi 21222864   87 LVDAAHAALHEERVALRAAG 106
gi 111017245  88 LLDAAHARLHTERTELALAK 107
gi 113945520  88 IVDAAHVLLQRDRETLDQVT 107
gi 56965537   83 LVSGEQAQLYNEKTVAEQTL 102
gi 15896746   81 KLIEGKQYAQDYIKIIQNEI 100
gi 109645109  81 KFSKAICLTEYYRQQIRNEQ 100
gi 90572961   81 DFDKAISLVNQYLQQLEIEK 100

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