Conserved Protein Domain Family
HTH_BltR

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cd04782: HTH_BltR 
Helix-Turn-Helix DNA binding domain of the BltR transcription regulator
Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BltR (BmrR-like transporter) of Bacillus subtilis, and related proteins; N-terminal domain. Blt, like Bmr, is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. These regulators are comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133409
View PSSM: cd04782
Aligned: 15 rows
Threshold Bit Score: 119.257
Threshold Setting Gi: 18309747
Created: 25-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DNA bindingdimer interface
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###             #                 ###                                          
gi 1303700     9 FTTGEFSKLCRVKKQTLFHYDEIGLFsPEIKKE-NGYRYYSyHQFETFQVISLFKeLGVPLKEIKCLIKgktpdkilHVL 87
gi 106894145   9 LTTGEFAKLCSIPKHILFHYDQIGLFqPEIIKE-NGYRYYSfRQYDTFSIIVALKqLGMPLKEIKKFMDernpsaliSLL 87
gi 106887326  14 FTTGEFAKRFGIKKDTLFYYDRIGLFhPAKVGD-NDYRYYTfEQLDVFWMLQSLReLNFPIKSLKNYVNdpspqkliDLS 92
gi 115251094   6 YKTSEFAELCGVKKHTLYHYDEIELLkPSITHE-NGYRYYTiDQFEKFNIISVLKkAGTPLEEIKQYLNdldtntflNVL 84
gi 115250037   9 FTTGEFAKICGINKKTLFHYDDIGLFsPELKKE-NGYRYYSyHQLSIFGIISSLReVKMPLKEIKAYIDkrtpnlliELL 87
gi 15896684    7 LSTGELAKMLGVTKQTVIYYDKVGLIsPAKRGE-KHYRYYTlEQADELDSILTFRnLGVPIDTLKEYLSvrnaegciEML 85
gi 77685031    9 FTTGEFANLVGVSKDTLFHYDKIGVFsPEIKGN-NHYRYYSvYQAEVFNVIATLKeVNMPLKEIKAYLNkrtpdeyiLLL 87
gi 28211480    6 YKINEVAKMHNISKKTLIYYDKIGLFkPQYVDEeNNYRYYEmKELPILKQIVYLKkIGFSLKEIKNLLDnrehdlviEAL 85
gi 104774042   6 IKTGDFAKMCAVTKKALYVYEAKGLLkPAVVKD-NGYRYYRlEQVDQVATIRLLEkLGSSLQEVGDFFAlkdlnerqKYL 84
gi 18309747    3 LSIGEVARLFNISKDTLRYYDKIGILkPEINKE-NGYRFYDiRHLEQLGLILGIKyLGISLSEIKEIIEngdiedyyNLM 81
                         90
                 ....*....|....*...
Feature 1                          
gi 1303700    88 KEKSIEIDKKINELKQLQ 105
gi 106894145  88 EQKSEEVTKELLRLQRVK 105
gi 106887326  93 KEQLTQVKEEIKKLEQIQ 110
gi 115251094  85 HRKLMDLQEEVKKIEKMC 102
gi 115250037  88 EKKTIDIKNEIEKLNNIQ 105
gi 15896684   86 GKQQERVILEIQKLDRIR 103
gi 77685031   88 EKEEASLDTKIRELQKMK 105
gi 28211480   86 ISRDKEIMNAMEELQEMH 103
gi 104774042  85 GKQQEAVEREMAELGKIK 102
gi 18309747   82 QKQKDIIKERILELKKLE 99

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