Conserved Protein Domain Family
HTH_MerR-like_sg7

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cd04786: HTH_MerR-like_sg7 
Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily
Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 7) with a conserved cysteine present in the C-terminal portion of the protein. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Statistics
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PSSM-Id: 133413
View PSSM: cd04786
Aligned: 5 rows
Threshold Bit Score: 226.631
Threshold Setting Gi: 17989362
Created: 4-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###             #                ###                                           
gi 107028430   1 MRIGELAKLSGISASRIRFYEAEGLITaVERSANGYRDYAdNAVWMLEIISSAQSAGFSLEQIRHLLPVKAGNWQHDGLV 80
gi 34498690    1 MKIGELAKRSGMAASAIRFDESKGLLQsASGQANGYRDYPpETAAALAIIRDAQQSGFSLDEIRQILPAGVSSWRHDELL 80
gi 117561714   1 MKIGELAKQTGMAASTIRFYEARGLLSkVRRGTNGYRDYPpETVPLLTIIGQAQQAGFSLDEIKQLVPADISSWQHAPLL 80
gi 17989362    1 MKIGELAKRSGLAASRIRFYESIGLLKtVDRRSNGYRTYPeEAVLVLHLIATAQKAGFSLDEIRTLLPPDLDNWEHDALI 80
gi 26989709    1 MRIGELAKISGLAPSRIRFYEASGLISsVERKANGYRDYApDTEWVLQLITSAQAAGFSLEEIRQLMPMDASGWRHDELL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                           
gi 107028430  81 AALERKVAEIEAMQKRLKENKAQLLVAIDSIRNRPTELDCTERTRWVMERL 131
gi 34498690   81 ATLRRKVADIESLQARLAQNKSHIQSLIQLIESKPGDMDCADNAARVMAVM 131
gi 117561714  81 AALEAKVSDIEALETRLAHSKQQLQALIRLVESKPDEMPCEENAARVLASM 131
gi 17989362   81 EVLRRKVADIEALEARLARSKLQLLGLISDIEAKPDDMACADNARRVLSRL 131
gi 26989709   81 TGLKQKVEEISALEERLAQNKAQLLRVIEGIEGKPEGMACADNAQMLINRL 131

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