Conserved Protein Domain Family
HTH_NolA-AlbR

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cd04788: HTH_NolA-AlbR 
Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR
Helix-turn-helix (HTH) transcription regulators NolA and AlbR, N-terminal domain. In Bradyrhizobium (Arachis) sp. NC92, NolA is required for efficient nodulation of host plants. In Xanthomonas albilineans, AlbR regulates the expression of the pathotoxin, albicidin. These proteins are putatively comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the C-terminal domains are often unrelated and bind specific coactivator molecules. They share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.
Statistics
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PSSM-Id: 133415
View PSSM: cd04788
Aligned: 8 rows
Threshold Bit Score: 127.879
Threshold Setting Gi: 21218949
Created: 25-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DNA bindingputative dimer
Feature 1:DNA binding residues [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to BmrR and the structure of Bacillus subtilis BmrR bound to DNA (1EXI).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###             #                ###                                           
gi 988279    11 WRIGELAGATGVTVRTLHHYEHTGLLaASERTDgGHRMYDrESIQRVHQIRALRELGFSLQEIRRAMDgrt-----sltD 85
gi 35214229   6 WKVGELARQTGLSVRTLHYYDEISLLsPSHYTEgGHRLYCtGDIARLQQIKSLRQLGFSLDEIRTSLErsdc----splE 81
gi 67543676   3 LKVGELAKRSGLTVRTLHHYHAIGLLaPSARADnGYRLYDrDDIARLHQIQALRRFGLSLAEIGDYLNqpgt----plvE 78
gi 78063512  12 LKIGDLAKRAGLSVRALHHYDAIGLLsPSQRTDgGARLYGrDDLVRLHRIEALKRFGYSLPDIKASLDgqla---gsplA 88
gi 51893322   6 WKIGELARRVGITVRTLHHYDHIGLLsPSSSTEaGHRVYSdADVRRLLSIISLKRLGFSLREIKVLLSdaae----dprA 81
gi 21224300   9 RHIGALARETGLSIRTLRYYDRLGLLtPSARTEgGHRCYDaGDVRRLHRVLALRSFGLPLARIRAVLDaepd---hdpaE 85
gi 21218949   1 MLIGEVARRSGVSARMLRHYESLGLVrPSGRTGsGYREYSrADIRRIFHIESLRSLGLSLREIGRALDepgfapaalvdD 80
gi 89893895   6 MKIGDLADLFGVTVRTLHYYHQIGLLiPSQTTAsGHRLYNeNDVKRLYQIITLKNFGFSLEEIGKMTSstdp----dplV 81
                        90       100
                ....*....|....*....|
Feature 1                           
gi 988279    86 LLRKHLQRIEVQVARATQLR 105
gi 35214229  82 VLQRHIAHVKEQIELQQRLC 101
gi 67543676  79 LVAKQIASLERQLAQAAQLR 98
gi 78063512  89 LLQRQIAELDAQASRAQRLG 108
gi 51893322  82 MLQVQLARLDEQIAALTEVR 101
gi 21224300  86 LIRRQLDVVEERLRQTAELR 105
gi 21218949  81 LIRRTRERIAAETELLTRLR 100
gi 89893895  82 LINLQVQKAAEALEFQQALY 101

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