Conserved Protein Domain Family
GT1_like_1

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cd04950: GT1_like_1 
Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Statistics
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PSSM-Id: 99999
View PSSM: cd04950
Aligned: 55 rows
Threshold Bit Score: 234.895
Threshold Setting Gi: 152963986
Created: 27-Aug-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33632233    1 MFDRPDILllatadWDHPLWTNKQHVACSLs----aLGHRVLYIESLgm------rTIQPTGRDWYRVWkrlrralqspr 70
gi 89076287    4 DIEFIIFGe-----DWGRHPSSTQHLISVIa-----KLYPVYWINSIgl------rQPQLQAKDIRRVIeklmafirrsv 67
gi 149276338  20 KIIGKDIVivg-qqPWDVSIGSNCKDIALEl----sKYNRVLYVNSAld------rISSIKGRDDEKVKmrkriisgkee 88
gi 86159063    3 ALTGRDIVcf--snDWDGDPLSKTHIMRILa-----RDNRVLWVNSLgn------rAPRATAADAARIWkklrdasrglt 69
gi 108762495   7 ALRGRDLVvf--snDWDGDPLSKVHIMRILs-----RENRILWVNSIgn------rAPKANAHDVKRIIdklgrftegvr 73
gi 118037274 177 HPDRRGVLlcp-vaYDLSLKQRPDHIMAEFa----kAGYLCVMLEFGgl-----ypVIQPKTKNLYVSN----------- 235
gi 67941099    1 MIRNRDIIvvg-laALDSRIGSNVINLAHEf----aKHNRVLYVNYPidrftlwreKNDPLIQNRVKRMkdkepslvkle 75
gi 157693955   5 KADSIIHVvva-tgEWGQDGLRYRRHRLAEflasdpETKEVIWVCPSssr---hiaPFQPITDRMKQLTipdvlksklfr 80
gi 52005300    2 KADQFIHViva-tgEWGQDQLRYRRHRLAEflagrkETKEVIWVCPSenps-retfTLLDNGIKQFAVKdflkkkifrfa 79
gi 46447806    3 MLEGRDFIvf--sdDWGRHPFSCQHIMQHFm-----PGNRVLWVNTIgmrlprlslYDMRRAAEKLRSWvfpvrqdgaaa 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33632233   71 qvrpriwic--------splvcpgvtkgllcqfnrwLLNATLWWmri--------rlGFRRPWLWTYSPLTLKFLdp--e 132
gi 89076287   68 iadtetsst-------nlkkiikplvwplarsktmkYINKRLLAtql--------pqKRQYRVLWIALPSAIEYIel--c 130
gi 149276338  89 gliflkdnlwtl--ypdvliesvnwinnaaifdffnKRNNRFFAesikk---amavlGFGDVLLFNDNDMFKSFYlqefl 163
gi 86159063   70 epernl-------------hvlaplyvpaygltavrRLNRALLRlqvra---amqrlAFGRPISWSFLPSAAAVAgt--l 131
gi 108762495  74 evepnihvl--------splaipfygselvrganrqLLRLQVLRamk--------klGFQKPISWSFLPASAPVSgt--l 135
gi 118037274 236 ------------------------------------MVEDFLGYf------------QDEPVTLYLHWPGFKYVAei--c 265
gi 67941099   76 knfwaly-----------patvlesisqlpvnwlfdILNNINNKrqakevnkaikelDFKDIIIFNDTDMFRSFFlkelt 144
gi 157693955  81 -------------------------fgryqdmfyihKLSPLLEHlrq-------eekKGIAVCLWYTFPGFPLLSsl--f 126
gi 52005300   80 r-----------------------ykdvfyqsklkpLLDRLKEDv------------QGEKVCLWYTFPGFPLLSsl--y 122
gi 46447806   76 spdglgdavpeglrvispvmvpfaplppvrafnrrsVVDAVTRNar---------emGFRDPVLLATVPNAADYVgh--c 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33632233  133 qFSLCVYHAVDAVQEQPCMPRgdie--------rqeRLLCAAVDQVf-vTSPELRRQLTPVS---RRLRf-DPNVVDQGH 199
gi 89076287  131 qADLIIYYCGDDFSALTGVDHak------------aIQAEQTLSIQadlIYVANRQLMARFPk--HKTHy-LPHGVDIHL 195
gi 149276338 164 tPELSIYYSRDYMLAVDYWKKhge---------riePELIRKSSLCv-aNSTYLADYCRQYN---PASFy-IGQGCDLGI 229
gi 86159063  132 gEALVVYHVVDEFSAFSDASAhva---------eleARLLRRADLVi-aSSERLLAAKRLVN---PRAVl-VRHGVDHAH 197
gi 108762495 136 gEAFVIYHCVDEFSAFSDTNGrhia--------eleERLLKRADLCi-tSAERLRENKARVN---PRTVl-VRHGTDFTH 202
gi 118037274 266 rAALTIYDVLDDLTIFANYSDvmr---------cdhEVLLQIANVCl-fSSNRLYEANRAKV---TNALl-LENGVYPED 331
gi 67941099  145 gAKTYAYYTRDNMIAVDFWKKqgi---------rieAALMAKADLVv-aNSTYLAELAGRFN---PHSFy-VGQGCDMSL 210
gi 157693955 127 eWKHIVYDCSDLWGEPISGNHnilsymrqrvivkaeNRIIKYAHSIt-cSSQYLHDQIKKRLmgePKDVftVENGVEYDV 205
gi 52005300  123 qWDQVIYDCSDLWAAPISGSQslvsgfrqkvifeaeGRIIKAADTIf-cTSEYLQQNVADRLqgeTKPVftIENGVEYSL 201
gi 46447806  145 gESLVVYYCVDEFTVWPGMNLpdmvrd----leadlMRSADLVVAVsdaLVRAKGNGRTPTR---LLTHg-VDVGHFARA 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33632233  200 FATAMTlkked-lpidlTEIPEPRVGFIGAIStyKLDVALVAAIARAHPSLNFVFIGPqge------geMTTDLSLWMd- 271
gi 89076287  196 FQSKQEcp-------paIGREKINIGFYGSLNn-WLDYELLQQLALARPQIQFYLLGN-----------KDCPQVQQLq- 255
gi 149276338 230 FTAADIttv-----peiMALKGPKIGYVGALQsiRLDIELIAQLAERRPDWQVVLVGPe---------dDVFRSSRLHq- 294
gi 86159063  198 FARALDpslav--paplAALPRPVIGFFGLVAd-WIDLPLVRQVADAYPQASVVLLGK-----------VVTSTAPLDg- 262
gi 108762495 203 FVKACDpatti--ptdiARLPKPIIGFFGLVAd-WVDQEAIIATARAHPGGSVVIIGKt---------tPDCDDSALRa- 269
gi 118037274 332 FIHGERercdvppelyeMVANRKVVGYHGAIS--ELLDFDLLDEIVRLSGIVLLFVGPvvafepqysveVQERMARLKt- 408
gi 67941099  211 FDKSLIknppe-dmvpiMELKKPIIGYIGVLFnlRLDIKVLEFLAKSRSDWSFVFVGPe---------dEHFQASELHq- 279
gi 157693955 206 FAKSNLpcke----dvlEGREGTVLGFIGGIKp-KLDFDMMAEAARMRPDWTFLFVGPd---------gTNGDPSFQHal 271
gi 52005300  202 FAENMQkad------vlKGREGTVLGFIGGIKp-KLDFKLVKEAARTKKEWTFLFVGPdg-------tnGDEDFKALLe- 266
gi 46447806  217 AAPQPLpe-------alSDLRGPVVGFFGLIDs-HLDVDIVEHILTARPQWNVVLIGT-----------RRIPLTRLEr- 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #    ## #              
gi 33632233  272 -rPNIHLLGprpYQELPGYcagFHCGWLPLQRnayTQAMFPMKFFEYLAAGLPVVATSIDSLQDFQs---vAWLCEp--- 344
gi 89076287  256 -nENIHLLPaipHHQLASYlqhWHAAILPFINnqqIKMCNPLKLREYLAAGCPVISSDFKAAEEYSp----LVSIAt--- 327
gi 149276338 295 -iPNIHFLGskpPKELPNYiqsFDVCINPQLVnqvTIGNYPRKIDEYLAMGKPVVATLTQAVGIFEd---cTYLAAs--- 367
gi 86159063  263 -aRNVHLLGrrpYQELPAWcrgFDVAITPFRRnelALAANPLKAREYVAAGLPNVCTDLPELRQVPg---cTVTRT---- 334
gi 108762495 270 -ePNIHMLGrkrYADLPGYskaFDVALMPFKVselTLNANPLKVREYLASGLPVVSTDLPEVRKVG-----LCKIAk--- 340
gi 118037274 409 -fDNFIHLGpkpYDELKHYlawIDVGIVPFVVsekTDPVSPLKLFEYLAAGKPVIGTPTRTIREYE-----HAMIVa--- 479
gi 67941099  280 -qKNVFFLGskkMEELPAYlnyFDVALNPQKLnevTIGNYPRKIDEYLAMGKPTVATKTKAMSVFAd---fTYLAEt--- 352
gi 157693955 272 klPNVIWTGavaAEEVPAYmklIDVGMMPYKQspyNQAVFPLKLYEFLAAGIPVVGLNLPSTERLKeknvyEYLVGd--- 348
gi 52005300  267 -eDNVIWTGpaaPSEVPAYmnvVDIGIMPYKPspyNNAVFPLKLFEFLAAGKPVAGMNLPSTEKVEq---eHVYRHltgn 342
gi 46447806  277 -hANFRWLPpvpYADLPRYayrFDVAVIPYVVnehTCTANPLKLKEYMATGRPVVTTPMPEALRYAa---cLHVATd--- 349
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                
gi 33632233  345 eLDEFSKALLGc--IQGEGPARSTRLa---lARQHTYTARMERMm----qTLRDGG 391
gi 89076287  328 tQLEWLSAIDRitqLNPQQVAEYKQKay-qcVQDDSWEIRIEKIi----hTIQKIR 378
gi 149276338 368 -ADDFVTMIEQg--MKEDTQERISYRkk--vAFSHSWENSVNELyka-iyHVKNIS 417
gi 86159063  335 -PEEFVEAVGRa--LRAGGPDPARSAl----VRAEGWEAKVDELr----aHVEAAE 379
gi 108762495 341 dTEDFVRKVDEc-lADKPGPNRERAEr----IFGESWDARVDEIrhhvgaALMADG 391
gi 118037274 480 sGIDFVDAVAS---GDWSTAYTEASAe---vAGAHAWPVLHAPL------LRQVNA 523
gi 67941099  353 -KEDYLQLIEKa--LKENSPEKEKGRev--fARSHTWEANANEIf----rRIDEIE 399
gi 157693955 349 dPALFIEACLKv--ISKKDDTAFRHLrq-srAKKKDWHALFTNMve--ltNIKENA 399
gi 52005300  343 dPAEFTAVCEE---LELAHDDVSHVElrrkiARERDWHHLFLMMl----dKLNLNK 391
gi 46447806  350 -GAGFVDAIDRe--LAAPSDAAPRRAa----LEGETWRDKAALLs----aWIEEGL 394

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