Conserved Protein Domain Family
GT1_WbdM_like

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cd04951: GT1_WbdM_like 
This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Statistics
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PSSM-Id: 100000
View PSSM: cd04951
Aligned: 12 rows
Threshold Bit Score: 484.086
Threshold Setting Gi: 113868842
Created: 21-Feb-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60493507    2 NILYIITglgiGGAEKVTVDLANLmqdkGNNVAILYLYGDnqytsliyksifv----kglsmsktpksfYLSLIKAREil 77
gi 90410714    2 KIIYLINsfgtGGAEKQVFSLCNEmh-kGNQVLLIRLKDDpsdlvqcldridvktislnmntikglllfFFSLAKEIK-- 78
gi 94311651   16 RILLVTTglkmGGAEHQVVALAHAflaqGQAVAILSLSPGreidvpadahvl------elnmsktpagmARALWQARGlv 89
gi 73540446    8 RILLLCTglkmGGAEQQIAALARQflrdGHAVAVVSLTAEqevslpegatvl------hlgmrktlpsfAMALWRLNRfv 81
gi 157369847   2 QIDYVITgleiGGAEYQVVSLLERlvqkGHQMRLISLTPPssavfigrlaaagv--plislemksakdlPLALLRLCKil 79
gi 5678719     2 KIVYIITgltcGGAEHLMTQLADQmfirGHDVNIICLTGIsevkptqninih------yvnmdknfrsfFRALFQVKKii 75
gi 16648660    2 KILYVITglglGGAEKQLSLLADNftarGEQVSIVYLTGEvlvkpknkniki-----ynlgidksfsslIKGIWKLKSii 76
gi 91211317    2 KILFVITglglGGAEKQVCLLADKlslsGHHVKIISLGHMsnnkvfpsennvn---vinvnmsknisgvIKGCVRIRDvi 78
gi 45644926    4 RIIFVITglglGGAEKQICLLADKlylhNNEVNIVVLNGNvnvtplneniri-----hnlhmkknplglLNAVLRLVKii 78
gi 145298460   2 KIAIVITglgmGGAERQVCDLADQfikiGHKVLLIVMTGEivnrpysagvdi-----allkmrknplsfVSSYWEAVKll 76
gi 53712839    2 NIIYVITglslGGAETITVCLANEmrrrGHHVAILYLTGEnwfkdridrdiiv----qslglsknpfslLKAQLKAKQfl 77
gi 113868842   2 RILLLTTglrlGGAERQVADLARQfvafGHEVAVVSLTLAqevalprevtlh------rvdlrkdplrfLLTLQAVRKwv 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60493507   78 kKFRPDVVHAQmfhaNIFARFlrff---ykipLLICTEHSKNIESKIRMRLYQITDFLSDVNTNVSREATEYFISHHAFS 154
gi 90410714   79 -AFSPDVIHAHlphsIIVARLyklif--nssvRLISTAHTSNIGSKHFKMLYKMTERYSDLNTNVSKLALNRYVDSGIFN 155
gi 94311651   90 kSWRPDVIHAHmihaNVFTRLltri---vqcpPVVCTAHSFREGGRLRMIAYRLTDRWSALTTHVSEDGREGMVASGAVQ 166
gi 73540446   82 rQWRPDVIHAHmvhaNLAARVlaal---tdgpPVLCSAHSAREGGQARMLAYRLTDRWASLTTHVSEAGRLAMIAAGAVA 158
gi 157369847  80 rQSKPDIVHAHmvhaNLLTRLarlf---lpslKIISTAHNTHEGGKLRDWAYRLTNPLCQINTTISEAATYRFTNENVLP 156
gi 5678719    76 vALKPDIIHSHmfhaNIFSRFirml---ipavPLICTAHNKNEGGNARMFCYRLSDFLASITTNVSKEAVQEFIARKATP 152
gi 16648660   77 sDVRPDVIHSHmyhaNILARIsccls--lfssRLVCSAHNKNEGGRVRMIIYRMTDFLCAKTTNVSQEALDEFITKKAFR 154
gi 91211317   79 aNFKPDIVHSHmfhaNIITRLsvigi--knrpGIISTAHNKNEGGYFRMLTYRITDCLSDCCTNVSKEAVDEFLRIKAFN 156
gi 45644926   79 sYFKPDIVHGHmfhaNIVARLakvft--ynkyKLICTAHSKNEGGHIRMLVYRLTDFLCDATTNVSNEALDVFIKKKAFS 156
gi 145298460  77 rQYKPDVVHSHmvhaNLFTRLvrlm---vfipKLICSAHSINEGGEVYMLAYRLTDRLCDLSTNVSQAAVDIFIKRRAVA 153
gi 53712839   78 kVFSPQVVHGNmvhaNIFVRLlrlh---chipLLISTEHNKNIEGRLRMKIYQYTDFLSDINTNVSREATTYFIQQKAFG 154
gi 113868842  76 gRWQPDIVHAHmfhaNIFARLlrpqraggapiPVLCTAHSSREGGRLRMLAYRLTDGLCAATTHVSAEGRQYMLDVGATT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60493507  155 DLKSFPMYNGIYLEKfeksnesklv--lknkiglenNEFVFLNVGRlvqAKDQTSLLLAFSDFlkty-----klnaKLVI 227
gi 90410714  156 GNKSFSVPNGFHIPDvdkydrrelrkeiveryafndNDFICLAISRlakVKNHEFMIKSIKKAlndn------ktiRLLI 229
gi 94311651  167 ADRIAVMPNGIDIERfrpsaalrgt--trarlgisaGTRLALNVGRlvpEKAQALLLRAFAQIdpat------lplHLLI 238
gi 73540446  159 PERIRVVPNGIDTALfrpdparrqs--traalgvdaDTRVIINVGRlvpEKAQHVLIEAFARLvrqadsatpsgamRLFI 236
gi 157369847 157 QHNTYTVFNGIDTDRfmppti----------kkvttSPFCWLAVGRlveQKDYPTLIQAFTHIss----------gKLLI 216
gi 5678719   153 KNKIVEIPNFINTNKfdfdinvrkk--trdafnlkdSTAVLLAVGRlveAKDYPNLLNAINHLilskts--ncndfILLI 228
gi 16648660  155 KRKSSLVYNGIDLSIfkkkstniqn--iknklginfDEKVIFCAGRlteAKDYPNLILAISKMhqk--------kcKIII 224
gi 91211317  157 PAKAITMYNGIDTNKfkfdllarre--irdginiknDDILLLAAGRltlAKDYPNLLNAMTLLpe---------hfKLII 225
gi 45644926  157 KSKSIPVYNGIDTDLfkydplqrdk--irhslniinDDSLILSVGRltdAKDYPNLLKALLELpe---------ryKLVI 225
gi 145298460 154 AGRMQVMYNGIDTRRfsfnivsrmq--lrfqlgvkeDTILLLAVGRltaAKDYKNLLKAFARLssqy------syvQLFI 225
gi 53712839  155 RNKSMTVYNGIDLVRfgrnedkrlk--irtqysvsnNEFLFLNVARltpAKDHVNLLLAFKETcsic------pdiKLLI 226
gi 113868842 156 AGRISVMPNGIDTDRfrrdpqaraq--trqalglgpDAKVVLNVGRlvhEKDQQRLIEAFRQLagdpe---tgasiRLLI 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60493507  228 VGEGPLRDNLcnyinnldiRENVILAGFHSNVSEYynaADCFVLSSLWEGFGIVLAEAMScGLPVITTDAGGCREVVEd- 306
gi 90410714  230 LGDGPELKNIkkmiseldvGNNVKLVGNVTDIYRYslaCDLYLMSSTYEGMPLTICEAMLsNLPILTTQFDGYEEFICd- 308
gi 94311651  239 AGGGPLHQALaeqitalnlSSRVTLLGPRSDVPALlnaADTFVLSSDIEGLPMVLVEALAsGCPVVATDAPGVREVVQd- 317
gi 73540446  237 VGAGQVRSTLeatidrlgvQSVVTLLGMRNDVPALlnaADVFALSSDIEGMPLVIGEALAsGCAVVATDAAGVAELLGd- 315
gi 157369847 217 AGQGPLDATLkqlvkhygiEDRVEFIGLSDDTAQLyrqVDGFVLSSAWEGYGLVVAEAMSsELPVVVTDSGGPREIVGsd 296
gi 5678719   229 AGDGALRNKLldlvcqlnlVDKVFFLGQRSDIKELmcaADLFVLSSEWEGFGLVVAEAMAcERPVVATDSGGVKEVVGp- 307
gi 16648660  225 AGDGPMRSDIerlidrchlSHRILLIGIIDNISDYynlSDLFVLPSRWEGFGLVVAEAMAcECPVIATDAGGVAEVLSn- 303
gi 91211317  226 IGDGELRDEInmlikklqlSNRVSLLGVKKNIAPYfsaCDIFVLSSRWEGFGLVVAEAMScERIVVGTDSGGVREVIGd- 304
gi 45644926  226 IGEGEARNEVertilnyglEKRVKLLGSIANVATYysaCDIYVSSSKWEGFGLVVAEAMScQRLVVATNAGGVAEVVGd- 304
gi 145298460 226 IGEGEDKAYLmsmvaaqglMARVHFLGLRYDIEKWmsaADIFVLSSAWEGFSLVVAEAMAtELLVVATDCGGVKEVVGt- 304
gi 53712839  227 VGDGELKKELeekvkelklINNVIFAGAHIHIEDYysaADCFVLSSAWEGFGLVLAEAMAaNLPVLTTDAGGCAEVVDd- 305
gi 113868842 231 AGDGPLKATLvrhaaalglSHAVRLLGPCDNVPALinaADLFVLSSVREGLPLVVAEALAcETPVVATDVSGIRALLAa- 309
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 60493507  307 --SRFVISl-qNPQEITLKMKeif--dmsLEERDMLGNm-nSIRAKKFDINIIGEKWTQIYSL 363
gi 90410714  309 --FYPSVAq-gDLEKYSKFINef----slGMYRDNINIa-kENVQNKYDIRSISKYWLTKFYQ 363
gi 94311651  318 --QGTIVPr-dDATALAVALDaal--rhgRGSSADEAAr-rAAMIARFSIDAVAQRWLEIYTG 374
gi 73540446  316 --AGKIVPc-gSVEALADALDram--acgVGMSGEQMAr-rQRIVDKFSLEAVARQWIGCYAA 372
gi 157369847 297 gtSGLIVPi-kDPLALANALIsie--kmpAHEREKMGAiarTRIQEKFSLNEIVTQWENIYTE 356
gi 5678719   308 --HNDVIPv-sNHILLAEKIAetl--kidDNARKIIGMknrEYIVSNFSIKTIVSEWERLYFK 365
gi 16648660  304 --ADWLVPi-aDSSKLAEKIDeffl-ldsSEVKDIKAKn-kDHCENQFSIGAIINNWYAIYNG 361
gi 91211317  305 --DDFLVPi-sDSTQLASKIEkl----slSQIRDHIGFrnrERILKNFSIDTIIMQWQELYGT 360
gi 45644926  305 --MNYIVPv-sDPQLLANKINevmefdheTKMEVMYRNr--EFVLKMFSIDMIVNQWMKLYSS 362
gi 145298460 305 --AGLLVPpqdSIRLSAAIEHall---lsPLEKEAITQearSRVINHYSIKVISQHWLTLYQD 362
gi 53712839  306 --YEYVVPt-hDPFLLADKMKkiv--imsPEEREQLGNt-nKDKAKRFDINSIVKEWEDLYLG 362
gi 113868842 310 --SGSIVPa-aDTDALARGMRaa----llGRQDVAAGR---AHAVAAYSLASVAQRWIDLYRE 362
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