Conserved Protein Domain Family
GT1_like_6

?
cd04955: GT1_like_6 
This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in certain bacteria and Archaea.
Statistics
?
PSSM-Id: 100001
View PSSM: cd04955
Aligned: 36 rows
Threshold Bit Score: 392.357
Threshold Setting Gi: 126733364
Created: 10-Sep-2007
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17132152   14 KIAVIGAkglppkqGGIEHYCAEVYPRiv-aqGHSVDLFARSSYtdtawlgnydFQGVRVISLpgi--darGADAFVTSA 90
gi 154493541   2 KIIVTGLrgfpniqGGVETHCEKLYPRls-klGVNVTVVRRSCFvkenp-pltsYQGVFFKDLpapkikgfESAIHTICG 79
gi 161396129   4 KITVIGTrgipnvlGGVETHCQHLYPEihrqfNNDICVIARSPYvdyk---issYQGVQTKAVwapkkkslEAIIHSTLA 80
gi 16265080   23 RVMMLGLrgipnvqGGVEKHVEMLAGRli-ahGWDVEVVGRRRYlavp--aphsWNGIRVTPLwsprmmalEAIVHTFLG 99
gi 158521819   7 KIFVTGTrgipdisGGVEKHCQELYPLia-aqGHDVFVATRKSYvndp--gvtaWGGVWLIHLyaprkkslEAAVHTFLA 83
gi 88793240    2 KICAIGLrgipdvmGGIESHCQQLYPKmv-rqGAEVTVLARSPYvsqk---ryeYEGVEVISVwalrhkllETFLHTFIA 77
gi 153007737   9 RVMMLGLrgvpnvqGGVEKHVEELARLyv-tkDWDVEVIGRRPYlekk--qpyvWEGVRVTPIwaptsmkfEAIVHTVLG 85
gi 149122064   5 DIFVFGFrgfpnvqGGIETHVEHLAPRlv-elGFAVTACSRSPYvgtp--rertWKGVTLLRIwtvrqtylETLMHSVAC 81
gi 37521763    2 KIAVIGSkglpaaqGGIERHCEEIYARlv-rlGHAVDIYARSTYtrpaaaghyeCQGVRVFPLpgv--pvkGFDALWTSA 78
gi 148264632   2 RIAYVAVkgi-pigGGIEKVTEEIGSRlv-erGHEVIVYASRDYgtt----dclYNGMRIKTVpsintkalHKLSICFMA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17132152   91 LGAIaataeRYDIVHFHALGPal-fTFLPRIan-saKIVVTCQGLDWQRAKWGsfstrLIQGGEQAAVRFAHGMVVVSDA 168
gi 154493541  80 VWYAyk--qKADIVHIHAIGPsiaiPFAKLLg---lKVVVTHHGPDYDRKNWNffakfILKTGEFFAAKWADEIIVISTV 154
gi 161396129  81 SLTTlf--dGSKVVHVHAIGPg---LVVPLLrllgkKVVFTHHGPDYDRQKWGgfakrILQLGEKLAATYANEVIVISEV 155
gi 16265080  100 VCYAal--rRPDILHIHAVGPa---LLVPLArlmrlNVVVTHHGYDYDRQKWGafarrMLRAGERMGMRLAQGRIAISRD 174
gi 158521819  84 VLKArq--vNPDILHVHAVGPclmvPLARLLg---mRVVMTHHGPDYERQKWNkpaklVLRLGEWLGGCFANEVIVISRI 158
gi 88793240   78 IIYArl-fvKPDIVHLHAIGPa---LFTPLArvlgmKVMVTHHGADYDRQKWSpfakkVLKFGEKMGITYGNRVLVVGRS 153
gi 153007737  86 VLRAgf--kRPDVLHIHAIGPa---LAVPLArllglRTVVTHHGFDYNRQKWGrlartMLKLGEWCGMRFANARIAVSND 160
gi 149122064  82 ALVAaf--rRPRLVHVHGIGPalvtPLLRLFg---lQVVVTHHGEDYNREKWGraarsVLVLGEYLGMKFANKRIAISRN 156
gi 37521763   79 LGTLwaclrRYDIVHFHAVGPal-fSALPRLls-paRVVVTCHGLDWQRSKWSraasaLLHQGERNGVHFAHELIVVSQE 156
gi 148264632  76 TLDVmf-reSVDLVHVHAVGPsifsLFPRLLg---iPTVVQTHGLEWKRDKWGiigkaFLKLAELSVVAFPSRATSVSLV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17132152  169 LKTYFa--ETYGRDt-VYIPNAPASYGesdl--sftYGKKLGLESGRYMIFVGRIVPEKRPDLLIEAFSKLqapgwKLVL 243
gi 154493541 155 IDNILk--TKYNRNnaILIYNGVDIHQptq---tdqYIKSLGLSHRKYILAVGRFVKEKEFDKLIMAFSDLnlqdyHLVI 229
gi 161396129 156 INNIIk--EKYNRYdaHLIYNGVKLPTqlpqekidsTLSKFSLTAGSYFVAVGRFVEEKGFHDLINAYQQAnl-niPLVI 232
gi 16265080  175 IADTMg--ERYRVPv-SLVPNGVTVSRsss---etgILGEFRLTRRRYILLAARLVPEKRQIDLIQAYAKLgnsgfDLVL 248
gi 158521819 159 IETLV---QKKCRRpcHVIYNGVRLPEkte---ktdYLETIGVSPGRYILAVARFVPEKGLDLLVKAFKEIrg-dfKLVI 231
gi 88793240  154 LSELVkhsFPKHSDkiSFVPNGMLPTLtgki-tpdyLPKDLGISANSYILTVGRLVPEKGFHDLVEAYKQSnv-spKLVI 231
gi 153007737 161 IAQTM---QQHFHVpiTFIPNGVTLRPacr---dktWLEKHGLLPERYIALVARIVPEKRQLDLIEAFAKLsdsslKLAL 234
gi 149122064 157 ICDLIq--SKYGLTc-ELIPNGVEVPDlpt---ndgRIRELGLRAGRYVLTIGRIVPEKRQLDLLRAFRRAgmadwKLVI 230
gi 37521763  157 LQSYFa--ATYGRTp-VYIPNAAASICesdp--dfpFVASLGLCPGRYLLFVGRLVPEKRPDLLIEAFKALkpegwQLVI 231
gi 148264632 152 QKQYFk--EKFGRDv-TYIPNGVSPVEkre----pcWLLQQGIIPGRYILFAARLVEEKGTHFLIQAFRKLnt-dmQLVI 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17132152  244 AGGvsDTQSYtsqllekvannPNIIFAGELRGPRLWEIVRGAGMFVLPSDlEGLPLAMLEAMQeGIPVVASDilPHQQLI 323
gi 154493541 230 AGDsdHKTSYstylk-elarkKQVILTGMVKGESLKELYSHAGLFVLPSShEGLPITLLEAMSyNIDTLVSDipANLAVG 308
gi 161396129 233 MGDtdHPTPYseklkqqardvDGVILTGFLKGDELQAIFSQAKTFVMPSYhEGLPIALLEAMSySLPAIVSNipANLEVK 312
gi 16265080  249 AGGaeFAGVYeeevralasrvPGVVLTGFQTGDRLAELFANAALFVLPSShEGMPIALLEAMAhGLPVLASDivANRQLG 328
gi 158521819 232 AGDadHETTYsrnlkeemagdDRIVSTGYITGEALNQVYSHAGLFVLPSFhEGLPIALLEAMSyGLPVLVSDipANREVD 311
gi 88793240  232 VGDadHEDDYskslk--rfasASIIFAGRRSGNELKALYQHASVFVLPSYhEGLPIVALEAISaGSKVLLSDisPNIDIE 309
gi 153007737 235 IGSaeYTAEYagavraradavPGVVLTGALQGEELSALFSQAALFVLPSShEGMPIALLEAMGyGLNVLASDitANVEVG 314
gi 149122064 231 VGQadHASSYaellaseaagdADVVMAGYRTGETLAQLYAHAGLFVLPSShEGLPIVLLEALSyGIPTLASDipSNREVI 310
gi 37521763  232 VGGssDTGAYaaela-rlgegGGVHFCGQLGGANLAEMIRGAGLFVLPSDlEGLPLVMLEAMQeCVPVVASDlpVHQQLT 310
gi 148264632 224 AGDaaHAEKYktllnelagddPRIIFTGFVNGEPLTELFSNAYLFCLPSTiEGLPVALLEAMNyGNCCLASDipENLEAL 303
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17132152  324 NggmGTLFMAGn---tDSLVSSLDwairhpqqVAAMAKNAQRNiql-nysWEHITAENLKLYK 382
gi 154493541 309 Ls-kEHYFKVNh---mNSLKQQLTyk-----iYQNNYPVYYDLka---ynWDHIAQQTFNVYN 359
gi 161396129 313 Lt-pDTYFSVGnt--eELTVQLVQhak---neYSNINYASYLEyy----dWEKIATQTMAVYQ 365
gi 16265080  329 Lp-aGDYFPLGnvdalSSAIAEKIanp--pdeQEVLAQTERVEav---ysWSSVALKTLDVYR 385
gi 158521819 312 Lp-eERFFRCGd---aPDLKKKIEalwd-kdlTVDEKNHFRNLlak-qynWDKIARQTIEVYE 368
gi 88793240  310 Ap-aDSYFKVGn---vEELSVKLSt------lSSLNLSLDREEflk-kydWESIATTTFGHAK 361
gi 153007737 315 Ls-eESYFPLGnvdalKDALRQKIdsp---ltSKQSQEMIDWIard--ysWSGIADRTLEVYK 371
gi 149122064 311 Sd-pTRIFKVGdiedlSTKMVEIVgv-----sVDQTAREAIRRndasrydWAKIARRTAAVYR 367
gi 37521763  311 YggrGLLFAAGdaeacRNSLQWAIehp---qqLAAMARSARRYvri-hhdWDRIAEQTLQVYR 369
gi 148264632 304 Ea-hGYTFRNRdvfdlRQRLAELVasp---ekVEAKKAAGAEHvyr-tysWDRVTDQMEELYR 361
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap