Conserved Protein Domain Family
GT1_like_5

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cd04962: GT1_like_5 
This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Statistics
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PSSM-Id: 100002
View PSSM: cd04962
Aligned: 19 rows
Threshold Bit Score: 487.902
Threshold Setting Gi: 46199051
Created: 19-Sep-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51892762    1 MRIGIVCYPsvGGSGIVATELAAQLArrGHEVHLVSSAVPFrlnrfeerirfh--qvetptyplfqEPPYVLTLANKLVE 78
gi 15806564   34 PKIAVLCHTgaGGSGVVATELGLKVAdaGHEVHFVGTAMPFrltghqglrgpyfhqvggfayalfeQPFPELSAANTLSE 113
gi 78043527    1 MKIGIVCYPgyGGSGVVAAELGKALGqkGIEVHFICLERPFrlegilpgiyyh--evepvdyplfkFPLYYLPLAGKIIE 78
gi 94971057    7 MKIGITCYPtyGGSGVVATELGIELAqrGHQVHFISYSQPIrltephpnihfh--evevsryplfeYPPYDLALATRMAE 84
gi 116626323   1 MNVGITCYPtyGGSGIVATELGMELAarGHEVHFITYANPIrldpgiprityh--evevstyplfqYPPYCLALASRMAE 78
gi 124005795   1 MNIGIVCYPtfGGSGVVATELGKALAqkGHKVHFITYSQPVrldffnenlfyh--qvyipnyplfqYRPYELALTSKMVN 78
gi 83815953    1 MKVGITCYPtyGGSGVVATELGKALAerDHEIHFIASDLPFrlshvagniffh--evnvqsyplfdYPPYTLSLTSKMVD 78
gi 146302307   1 MKIAIVCYPtfGGSGVVATELGLELArrGHEIHFITYSQPVrlallnpnvhyh--evnvpeyplfhYQPYELALSSKLVD 78
gi 134300162   1 MKVGMLCHAsyGGSGVVAAELGKCLAkrGHEVHFITVGRPFrlenyqknifih--evgafhhplfeVPPYFITQVNKTLE 78
gi 156339504   1 MKIAIVCYPtfGGSGVVATELGLELArkGHEIHFITYSQPVrlallnqniyyh--evhvpeyplfhYQPYELALSSKLVD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51892762   79 VHRIAgLDVIHAHYAVPHATAAYLAREIiga-----ggpRVVTTLHGTDITLMGADPsfTEIIAFSINRSDEVTAVSESL 153
gi 15806564  114 VILEHgVDLTHAHYAIPHASAALHARSItg-------ktRVLTTLHGTDVTLVGTEPafQHTTRHAIERSDHVTAVSHSL 186
gi 78043527   79 VVRTYhIDLIHTHYAIPHTVAALMAKEIlsse---gkelKVITTLHGTDVTLVGQRRelFDVTRWSILKSDGVTAVSEYL 155
gi 94971057   85 VAEIYnLDLLHVHYAIPHSVSALLAREMtafgpgrkrhlPFVTTLHGTDITLVGLDPsyLPITRFSIEKSDGVTSISNYL 164
gi 116626323  79 VAQTYkLDLLHVHYAVPHAVSAMLAQQMlapi----rrlPFITTLHGTDITLVGIDPsyFSITKFSIEQSNGITSISDDL 154
gi 124005795  79 VVKYEkLDLLHVHYAIPHASAAYMAKQIlkse---gisiPVITTLHGTDITLVGKDPsfAPVVTFSINESDGVTAVSESL 155
gi 83815953   79 IAKHVgLDLLHVHYALPHASSAVMAQQIlsse---dldlPIVTTLHGTDITLIGRDPsfAPVVTWSINESDGVTAVSDYL 155
gi 146302307  79 MVKLYkIEVLHVHYAIPHAYAGYMAKQMlkne---ginlPMITTLHGTDITLVGNHPfyKPAVTFSINKSDYVTSVSQSL 155
gi 134300162  79 VLRNYdLDLLHAHYAVPHSLSALLARQIfgk------yiPVITTLHGTDTSLVGAHQefYQTTRYSLEKSDLVTVVSSFL 152
gi 156339504  79 MVKLHkIEVLHVHYAIPHAYAGYMAKKMleed---giriPMVTTLHGTDITLVGNHPfyKPAVSFSINKSDVVTSVSSSL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51892762  154 RTDtvtll-pvdrpVRVIPNFLDCARWRrqeagel-rrrlapeGERLLMHMSNFRRVKRPWDVVEVFARVarr-lpSRLI 230
gi 15806564  187 AAEtrevf-gvdrdIEVIHNFVDSDRFRripdpgv-rarfahpEEALIVHVSNFRPIKRVEDVVQVFARIase-ipARLL 263
gi 78043527  156 KNVtceifaisprtIEVIYNFVDLDEYRpktdeslkeklgvpeKQKVIIHISNFRPVKRALDVLEIFSKVqte-vdSVLV 234
gi 94971057  165 REKtlqaf-gikneIRVIPNFVNCDIYHrdgktqhyrkewapnGERVVVHLSNFRPVKRVPDVIEIFERIqqr-vpAKLV 242
gi 116626323 155 RNQtvevf-gvtkeIRVIKNFVNCSLYHsddekrg-aalyapnGEKLLIHLSNFRPVKRPLDCIRIFAEVrkq-vpARLL 231
gi 124005795 156 RKDtyshf-kirngIEVIPNFIDLERFKkqkkehf-kraicphGEKLLVHTSNFRKVKRIEDVLYTFSKVvke-ipAKLL 232
gi 83815953  156 RQEtydhf-evsedVEVIPNFIDTDRFVrqdkehf-kqalcpnGEKVIVHVSNFRPVKNTDQVVEVFHRLqngtsnVKLL 233
gi 146302307 156 KDDtlklf-kiknkIKVIPNFIELDKVRkdptepchryvmakeNERIVTHISNFRKVKRIPDIIKIFYNIqke-mpAKLM 233
gi 134300162 153 AEQtrqtf-hftgeLPVLYNFVNTEVFKpevrier--ksvariDEAILIHISNFRPLKRVLDVIHIFKGVrqk-rrARLI 228
gi 156339504 156 KEDtyrlf-dikndIKVIPNFIEISKEKldengpchrslmataEEKMLTHISNFRKVKRISDVVRIFYEVqkq-ipSKLM 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51892762  231 LVGEGPELAPTlslaarlgvrDRVLVLGnQEEVAPLLsaADLFLLPSEQESFGLAALEAMAcGVPVVVSRTGGLPEVVAe 310
gi 15806564  264 MIGDGPERARAfelarelgviGRTQFLGsFPDVQTVLgiSDLFLLTSSHESFGLAALEAMScEVPVVASNAGGIPEVVQh 343
gi 78043527  235 YVGEGPDTGKVlnevqkknltNKVKFLGkMPKVSDVLsiSDVLLITSETESFGLVALEAMAmEVPVVAYRVGGLPEVVVd 314
gi 94971057  243 MIGDGPDRSRAewmvvekklqDRVLFLGkQDDVHEKLpaADLMLMPSTLESFGLAALEAMAcEVVPVATKAGGVPEVIDh 322
gi 116626323 232 MVGDGPERGPAehlartfnvqDDVIFLGkQNHVERLIplAHVLLMPSEMESFGLAALEAMAcGVVPVATRVGGVPELITh 311
gi 124005795 233 LVGDGPERSNLealcrelgtcEDVSFIGkIDAVEEVLsvSDLFLMPSEKESFGLAALEAMAcEVPVVSSDAGGIPEVNVh 312
gi 83815953  234 LVGDGPDRVPTerkarelgvyDDIRFLGkQDPIEEILsiADVFLMPSGSETFGLAALEAMAcEVPVVASDVGGLPELVVh 313
gi 146302307 234 MVGDGPEKEKAevlcmelgihDKVIFFGnSNEIDKILcmTDLFLLPSETESFGLAALEAMAcGVPVISSNSGGLPEVNFd 313
gi 134300162 229 LIGDGPDMPAVqklakrlgltQDINFLGqIDNVAPILaaADVLLYPSSCESFGLVALESLScGVPVVAAHACGIPEVVIh 308
gi 156339504 234 MVGDGPEKEAAenlcvelgiqNKVIFFGnSNEIDKILcfTDLFLLPSETESFGLAALEAMAcGVPVISSNSGGLPEVNKd 313
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 51892762  311 gETGFLCRvgdVETMAERALQILEDGRLHARLSAAAVewvrTHFCAERVVPQYEALYRTV 370
gi 15806564  344 gVNGFLSDvgdVDDMAHHALKILRDQETYQQMGQAARrtavEQFHPRLIVPQYLAAYRRL 403
gi 78043527  315 gQTGYLVDyldLEKAAEAVVKLLKEPWLKRDFGRWGRirakERFSKEKQVINYLNYYEKI 374
gi 94971057  323 gVDGYLADvgdIDTMAMYSIDILSDDEKLHEMAKMARfkaqSTYCASKIIPMYEDFYREV 382
gi 116626323 312 gEDGFLEEvgdIEAQAARVVSLLTDDDLHYRMAKAGRwnasERFCTDRIIPQYEKHYADV 371
gi 124005795 313 gKTGFISKigdVEDMAKNALFVLDDDNLPSFKANALAr--aKEFDLSQILPLYEGYYHKI 370
gi 83815953  314 gETGFLCQlddVDAFTEHTRTLLHDEDQHAEMAAAARkravETFDIDRVVPLYEDYYERV 373
gi 146302307 314 gVSGYLSDvgnVDEMAANAIKILKDDKTLNEFKANALev-aKNFDIKNILPKYEALYQRA 372
gi 134300162 309 gQVGFLAEvgdVKEMARYTLMLLEDNDLKQKISNNARnyaiSQFNAEQWVVKYESIYKEL 368
gi 156339504 314 gITGYLSNvgdIESMSKNAISILEDDAKLNVFKRNALkv-aSDFDIKKILPLYEEVQKLF 372
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