1CS6,2OM5


Conserved Protein Domain Family
Ig1_Contactin

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cd04967: Ig1_Contactin 
Click on image for an interactive view with Cn3D
First immunoglobulin (Ig) domain of contactin
Ig1_Contactin: First Ig domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.
Statistics
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PSSM-Id: 319276
View PSSM: cd04967
Aligned: 4 rows
Threshold Bit Score: 177.021
Threshold Setting Gi: 55976223
Created: 27-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
interdomain
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:interdomain interface [polypeptide binding site]
Evidence:
  • Structure:1CS6_A; Gallus gallus axonin-1 Ig1/Ig4 interdomain interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Chicken axonin-1 domains Ig1 and Ig4 interact with each other, helping to form the U shaped structure of the intermolecular binding fragment.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##                                                                              
1CS6_A         4 GPVFEEQPAHTLFpegsaeekVTLTCRaranPPATYRWKMngtelkmgpdsRYRLvaGDLVISNPvkakDAGSYQCVATN 83
2OM5_A         3 GPVFEDQPLSVLFpeesteeqVLLACRarasPPATYRWKMngtemklepgsRHQLvgGNLVIMNPtkaqDAGVYQCLASN 82
gi 55976223   98 GPVFVQEPDDIIFptdsdekkVALNCEvrgnPVPSYRWLRngteidlesdyRYSLidGTFIISNPseakDSGHYQCLATN 177
gi 2497301    40 GPIFEEQPINTIYpeeslegkVSLNCRarasPFPVYKWRMnngdv-dltsdRYSMvgGNLVINNPdkqkDAGIYYCLASN 118
                         90
                 ....*....|.
Feature 1          ####     
1CS6_A        84 arGTVVSREAS 94
2OM5_A        83 pvGTVVSREAI 93
gi 55976223  178 tvGSILSREAT 188
gi 2497301   119 nyGMVRSTEAT 129

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