1CS6,2OM5


Conserved Protein Domain Family
Ig3_Contactin

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cd04968: Ig3_Contactin 
Click on image for an interactive view with Cn3D
Third immunoglobulin (Ig) domain of contactin
Ig3_Contactin_like: Third Ig domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III(FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal act ivity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.
Statistics
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PSSM-Id: 319277
View PSSM: cd04968
Aligned: 6 rows
Threshold Bit Score: 171.189
Threshold Setting Gi: 2497301
Created: 22-Feb-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
interdomaindimerization
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:interdomain interface [polypeptide binding site]
Evidence:
  • Structure:1CS6_A, chicken axonin-1 Ig2/Ig3 interdomain interaction, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Axonin-1 domains Ig2 and Ig3 interact with each other, helping to form a U-shaped axonin structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              # ##### #                                                  
1CS6_A        207 PSIKAKFPADTYAltgqMVTLECFAFGNPVPQIKWRKLDGSQTSKWls---sePLLHIQnvdfEDEGTYECEAENikgRD 283
2OM5_A        206 PSIKARFPAETYAlvgqQVTLECFAFGNPVPRIKWRKVDGSLSPQWtt---aePTLQIPsvsfEDEGTYECEAENskgRD 282
gi 399092     239 PSIKARFPAETYAlvgqQVTLECFAFGNPVPRIKWRKVDGSLSPQWtt---aePTLQIPsvsfEDEGTYECEAENskgRD 315
gi 148228227  226 PKIEVHFPESVSSakgsTVKLECFALGNPVPTITWRRADGKPISRKvrrhrssGVLEIPnfqqEDAGPYECVAENtrgKN 305
gi 118097101  109 PKIEVQFPETLPAakgsTVKLECFALGNPVPQINWRRTDGMPFPSKiklrksnGMIEIPnfqqEDAGLYECITENsrgKN 188
gi 2497301    241 PADIVVQFKDVYAlmgqNVTLECFALGNPVPDIRWRKVLEPMPSTAeis-tsgAVLKIFniqlEDEGIYECEAENirgKD 319

                  ....*....
Feature 1                  
1CS6_A        284 TYQGRIIIH 292
2OM5_A        283 TVQGRIIVQ 291
gi 399092     316 TVQGRIIVQ 324
gi 148228227  306 MVRGQLTYF 314
gi 118097101  189 IARGRLTYY 197
gi 2497301    320 KHQARIYVQ 328

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