Conserved Protein Domain Family
Ig6_Contactin

?
cd04970: Ig6_Contactin 
Sixth immunoglobulin (Ig) domain of contactin
Ig6_Contactin_like: Sixth Ig domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neur onal act ivity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.
Statistics
?
PSSM-Id: 319279
View PSSM: cd04970
Aligned: 5 rows
Threshold Bit Score: 139.61
Threshold Setting Gi: 115953054
Created: 22-Feb-2007
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114735     519 ENLTLQCHasHDPTMDLTFTWSLDDfpidldkseghyrrasvkeavGDLAIvnaqLKHSGRYTCTAQTVVDsTSESATLT 598
gi 2497301    520 ENATMQCAasFDPALDLTFVWSFNGyvidfnkenihyqrnfmldsnGELLIrnaqLKHAGRYTCTAQTIVDnSSASADLV 599
gi 115953054  518 QSTTLKCKaaHDEYLELTYLWEHNGveidlsei-----eryrmrdnGNLEIvsaqLRDGGEYTCVALTVADsDRSSATLD 592
gi 118097058  515 ESIVLPCQvsHDHSLDIVFTWSFNGhlidfekdgdhfervggqdsaGDLMIrsiqLKHAGKYVCMVQTSVDkLSAAADLI 594
gi 18858449   525 ENATLQCHasHDPTMDLTFTWSLNGvpldleepnghyrrmegketiGDLVIvngqLSHAGTYTCTAQTVVDsAMASAKLV 604

                  ....*
gi 114735     599 VRGPP 603
gi 2497301    600 VRGPP 604
gi 115953054  593 IAGPP 597
gi 118097058  595 VRGPP 599
gi 18858449   605 VRGPP 609
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap