2IFG


Conserved Protein Domain Family
Ig_TrkABC_d4

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cd04972: Ig_TrkABC_d4 
Click on image for an interactive view with Cn3D
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
TrkABC_d4: the fourth domain of Trk receptors TrkA, TrkB and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains. The fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, B, and C mediate the trophic effects of the neurotrophin Nerve growth factor (NGF) family. TrkA is recognized by NGF. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system.
Statistics
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PSSM-Id: 143173
View PSSM: cd04972
Aligned: 7 rows
Threshold Bit Score: 71.7788
Threshold Setting Gi: 119883
Created: 15-Feb-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
interdomain
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:interdomain interface [polypeptide binding site]
Evidence:
  • Structure:2IFG_F, human TrkA interface between domains 4 and 5; contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                          
2IFG_A         160 TLKVQVPnas---vdvGDDVLLRCQVEGrGLEQAGWILTEleqsatvm---------------------------ksggl 209
gi 134035335   211 EISVSHVnlt---vreGDNAVITCNGSGsPLPDVDWIVTGlqsinthqt------------------------nlnwtnv 263
gi 119883      235 YAPVHQPdaavyglylEHTAIVNITIRAsPQPKIEWTIDGaivgqgrtdgrysayepqylgndeynvtlaiagltledtt 314
gi 129892      415 SSILDLVddh---hgsTGGQTVRCTAEGtPLPDIEWMICKdikkcnn-----------------------------etsw 462
gi 74961937   1818 DNGVEGSttiq--ilpGSQMTIACNATGiPLPQVKWIKAGnyeidpsrv-------------------------dadgnh 1870
gi 74961937   1204 TITLDPSnsty-tvepLGAATITCTATGvPQPKVHWIKANget------------------------------------v 1246
gi 82583720   2075 PIVVDGPksvt--ikeTETAEFKATISGfPAPTVKWTINEkiveesrti-------------------------ttikte 2127
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
Feature 1                                                 ##
2IFG_A         210 psLGLTLANVTSdl-nrKNVTCWAEnd--vGRAEVSVQVNV 247
gi 134035335   264 haINLTLVNVTSed-ngFTLTCIAEnv--vGMSNASVALTV 301
gi 119883      315 kiYNLRASNELGltdyqVRISSSSKpp--sSSLDVAAIVGI 353
gi 129892      463 tiLANNVSNIITei--hSRDRSTVEg----RVTFAKVEETI 497
gi 74961937   1871 aqFSLQVANITEd----TTFNCVAQnp--lGHANWTINVNL 1905
gi 74961937   1247 dsATLQLYDLVKd----TSATCVAEnnagkTQEAVSIQVTG 1283
gi 82583720   2128 dvYTLKISNAKIeq--tGTVKVTAQns--aGQDSKQADLKV 2164

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