2CKN


Conserved Protein Domain Family
Ig1_FGFR

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cd04973: Ig1_FGFR 
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First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Ig1_FGFR: The first immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR). Fibroblast growth factors (FGFs) participate in morphogenesis, development, angiogenesis, and wound healing. These FGF-stimulated processes are mediated by four FGFR tyrosine kinases (FGRF1-4). FGFRs are comprised of an extracellular portion consisting of three Ig-like domains, a transmembrane helix, and a cytoplasmic portion having protein tyrosine kinase activity. The highly conserved Ig-like domains 2 and 3, and the linker region between D2 and D3 define a general binding site for all FGFs.
Statistics
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PSSM-Id: 143174
View PSSM: cd04973
Aligned: 6 rows
Threshold Bit Score: 145.416
Threshold Setting Gi: 109157343
Created: 18-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30        40        50        60        70
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2CKN_A     16 VESLLVHPGDLLQLRCRLrddvqSINWLRDGVQLVESNRTRITGEEVEVrdsiPADSGLYACVTSspsgsDTTYFSVNV 94
gi 120048  39 VEPYSAQPGDRITLQCRLredvqSINWVKNGVQLSETNRTRITGEEIQIsnagPEDNGVYACVTNgpsrtYTVLCSVNV 117
gi 120045  39 VESHSAHPGDLLQLRCRLrddvqSINWVRDGVQLPENNRTRITGEEVEVrdavPEDSGLYACMTNspsgsETTYFSVNV 117
gi 120049  47 PEVYVAAPGESLEVRCLLkd-aaVISWTKDGVHLGPNNRTVLIGEYLQIkgatPRDSGLYACTASrtvdsETWYFMVNV 124
gi 116098  50 PDVHSALPGEPLELRCQLkd-avMISWTKDGVPLGPDNRTVIIGEYLQIkdasPRDSGLYACTAIrtldsDTLYFIVNV 127
gi 182530  40 VESFLVHPGDLLQLRCRLrddvqSINWLRDGVQLAESNRTRITGEEVEVqdsvPADSGLYACVTSspsgsDTTYFSVNV 118
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