1BYG,1K9A,1K9A,3D7T


Conserved Protein Domain Family
PTKc_Csk

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cd05082: PTKc_Csk 
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 133213
View PSSM: cd05082
Aligned: 8 rows
Threshold Bit Score: 557.673
Threshold Setting Gi: 729886
Created: 21-Jun-2007
Updated: 2-Mar-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     ###     #          # #                          #                ##
1BYG_A        16 WALNMKELKLLQTIGKGEFGDVMLGDYRgNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVeeKGGLYIVTE 95
1K9A_F       188 WALNMKELKLLQTIGKGEFGDVMLGDYRgNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVeeKGGLYIVTE 267
1K9A_C       188 WALNMKELKLLQTIGKGEFGDVMLGDYRgNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVeeKGGLYIVTE 267
gi 729886    188 WALNMKDLKLLQIIGKGEFGDVMLGDYRgNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVeeKSGLYIVTE 267
gi 2967840   188 WALKMRDLKLQHTIGKGEFGDVMLGEHQgVKVAVKCIKNDATAQAFIAEAMVMTQLQHKNLVQLLGVIVedKSGLFIVTE 267
gi 117606200 188 WALNRKELKLIQTIGKGEFGDVMVGDYRgKKVAVKCIKHDATAQAFVAEASVMTQLRHNNLVQLLGVIVeeKGSLYIVTE 267
gi 47224486  184 WAMNMEDLTLQQVIGKGEFGDVMVGDYRgTKVAVKCIKNDATAQAFIAEASVMTQLRHDNLVQLLGVIVeeNGSLYIVTE 263
3D7T_A         7 WALNMKELKLLQTIGKGEFGDVMLGDYRgNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVeeKGGLYIVTE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  ##                                            ## #         ##               
1BYG_A        96 YMAKGSLVDYLRSRGRsvLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEdNVAKVSDFGLTKEASSTQDTGK 175
1K9A_F       268 YMAKGSLVDYLRSRGRsvLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEdNVAKVSDFGLTKEASSTQDTGK 347
1K9A_C       268 YMAKGSLVDYLRSRGRsvLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEdNVAKVSDFGLTKEASSTQDTGK 347
gi 729886    268 YMAKGSLVDYLRSRGRsvLGGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEdNIAKVSDFGLTKEASSTQDTGK 347
gi 2967840   268 FMAKGSLVDYLRSRGRsvLGGECLLKFSLDVSEGMEYLESNNFVHRDLAARNVLVSEeNIAKVSDFGLTKEASAIQDTSK 347
gi 117606200 268 YMAKGSLVDYLRSRGRtvIGGDRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEdNIAKVSDFGLTKEASSTQDTAK 347
gi 47224486  264 YMAKGCLVDYLRSRGRsvLDGDALLHFALDVCEAMAYLEANSFIHRDLAARNVLVSEdNVAKVSDFGLTKEVSSTQDTAK 343
3D7T_A        87 YMAKGSLVDYLRSRGRsvLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEdNVAKVSDFGLTKEASSTQDTGK 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1BYG_A       176 LPVKWTAPEALREkKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDA 255
1K9A_F       348 LPVKWTAPEALREkKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDA 427
1K9A_C       348 LPVKWTAPEALREkKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDA 427
gi 729886    348 LPVKWTAPEALREkKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDP 427
gi 2967840   348 LPVKWTAPEALREkLFSTKSDVWSFGILLWEIYSFGRVPYPRIALKEVVPKVENGYKMDAPDGCPPVVYDLMKQCWHLDP 427
gi 117606200 348 LPVKWTSPEALREkKFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDA 427
gi 47224486  344 LPVKWTAPEALREkRFSTKSDVWSYGILLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDCPDGCPEVVYNIMKQCWNLDP 423
3D7T_A       167 LPVKWTAPEALREaAFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDA 246
                        250
                 ....*....|....*.
Feature 1                        
1BYG_A       256 AMRPSFLQLREQLEHI 271
1K9A_F       428 ATRPTFLQLREQLEHI 443
1K9A_C       428 ATRPTFLQLREQLEHI 443
gi 729886    428 GHRPSFHQLREQLVHI 443
gi 2967840   428 KQRPTFRNLREQLEHI 443
gi 117606200 428 VVRPSFRDLREKLQDI 443
gi 47224486  424 TARPSFEMLKEWLQHI 439
3D7T_A       247 AMRPSFLQLREQLEHI 262

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