Conserved Protein Domain Family
PTKc_DDR1

?
cd05096: PTKc_DDR1 
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
?
PSSM-Id: 133227
View PSSM: cd05096
Aligned: 3 rows
Threshold Bit Score: 621.954
Threshold Setting Gi: 47221550
Created: 9-Jul-2007
Updated: 2-Mar-2014
Structure
?
Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:Based on the structures of other PTK family members bound to substrate peptides and ATP analogs.
  • Citation:PMID 9312016

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #####   #                            # #                            
gi 47125290  567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPqdlvsldFPLNVRKGHPLLVAVKILRPDAtknaRNDFLKEVKIMSRLKDPN 646
gi 38173765  636 KFPRGHLLFREKLGEGQFGEVHLCEVVNPhelptlqFPFNMRKGRSLLVAVKLLRADAnknaRSDFLKELKILSRLSDPH 715
gi 47221550  745 ELPRQCLIFKEKLGEGQFGEVHLCEIENPqdlpileFPFNVRKGRPLLVAVKILRPDAsknaRNDFLKEVKILSRLKDPN 824
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         ####  ##                                                       
gi 47125290  647 IIRLLGVCVqddPLCMITDYMENGDLNQFLSAHQLedkaaegapg------------------dgqaaqgptISYQMLLH 708
gi 38173765  716 IIRLLGACLdedPLCMITEYMENGDLNQFLSSHHLdegeeng------------------------ahclpaISYSSLLH 771
gi 47221550  825 IIRLLGVCVssdPLCMVTEYMECGDLNQYLSHRVLldktgpsndaptirweaeggghmmvpatvppdgpllvPSYPALIS 904
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #   ## #                     #                 #####        
gi 47125290  709 VAAQIASGMRYLATLNFVHRDLATRNCLVGEn-----------FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWEC 777
gi 38173765  772 VALQICSGMKYLSSLNFVHRDLASRNCLVGEn-----------LTIKIADFGMSRNLYAGDYYRIQGRAVLPIRWMAWEC 840
gi 47221550  905 MASQIASGMKFLSSLNFVHRDLATRNCLVGGergdsgddgggeRHIKIADFGMSRNLYAGDYYRIQGRAVLPIRWMAWEC 984
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #                                  #                                            
gi 47125290  778 ILMgKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDqgRQVYLSRPPACpQGLYELMLRCWSReSEQ 857
gi 38173765  841 ILMgKFTTASDVWAFGVTLWEILMLCKEQPYGELSDEDVIENAGEIFRDskKQIFLFRPPPCpQPLYELMLQCWSRdCRE 920
gi 47221550  985 ILMgKFTTASDAWAFGVTLWEMLSVCQEQPYSSLTDEQVIDNAGEFFRDqgRQVYLGRPAVCpQGLYELMLSCWSRdCKL 1064
                        330
                 ....*....|...
Feature 1                     
gi 47125290  858 RPPFSQLHRFLAE 870
gi 38173765  921 RPSFQDIHALITS 933
gi 47221550 1065 RPSFSDIHSFLTE 1077

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap