1KHC,1H3Z,1N27,2DAQ,2GFU


Conserved Protein Domain Family
PWWP

?
cd05162: PWWP 
Click on image for an interactive view with Cn3D
The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. The function of the PWWP domain is still not known precisely; however, based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.
Statistics
?
PSSM-Id: 99894
View PSSM: cd05162
Aligned: 13 rows
Threshold Bit Score: 80.5151
Threshold Setting Gi: 74762184
Created: 25-Apr-2007
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Possible chromatin binding property is supported by its charasteristic electrostatic charge distribution. Upon binding, the charged surfaces may form nonspecific contacts with the nucleic acid on the basic side and contact the core histone molecules along the acidic surface.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  #  #                                          #       # #          
1KHC_A         12 FGIGDLVWGKIkgFSWWPAMVVSwkatskr-------------------qampgmRWVQWFg-----DGKFSEISADKLV 67
1H3Z_A          7 YKPGMRVLTKMsgFPWWPSMVVTeskmtsvark-------------skpkragtfYPVIFFp-----NKEYLWTGSDSLT 68
1N27_A          9 YKAGDLVFAKMkgYPHWPARIDElpegav--------------------kppankYPIFFFg-----THETAFLGPKDLF 63
2DAQ_A          9 LHYKQIVWVKLgnYRWWPAEICNprsvplniq---------------glkhdlgdFPVFFFg-----SHDYYWVHQGRVF 68
2GFU_A         23 FSPGDLVWAKMegYPWWPSLVYNhpfdgtfi----------------rekgksvrVHVQFFd----dSPTRGWVSKRLLK 82
gi 10719919   238 IPNHELVWAKMkgFGFWPAKVMQked---------------------------nqVDVRFFg----hHHQRAWIPSENIQ 286
gi 156542480  862 LTALQLVWAKCrgYPWYPALIIDpntprgtvhkgvpipsppddvlalasnykdrvYLVLFFd----tKRTWQWLPGEKLE 937
gi 71297202     6 LRLGDLVWGKLgrYPPWPGKIVNppkdlkk-------------------prgkkcFFVKFFg-----TEDHAWIKVEQLK 61
gi 74762184   390 FETGMIVWFKYqkYPFWPAVIKSirrk-------------------------erkASVLFVeanmnsEKKGIRVNFRRLK 444
gi 15232737   197 ISDSDLVWAKVrsHPWWPGQVFDasaatdka----------------kkhfkkgsFLVTYFg-----DCTFAWNEASRIK 255
gi 62732809   114 FAPPELVWGKVrsHPWWPGQVFDaadaskla----------------lkhtragaPLVAYFw-----DKTFAWSDASSLL 172
gi 53980941    44 VRFGDMVWGKVksHPWWPGHVYSitltsdgev---------------rrgyrdglVLVAFFg-----DSSYGWFEPHELL 103
gi 145355721  596 PRRNQLVWAKLpgHPFWPGLRADldkdfipad--------------alamareneVLVVFFg-----ENSFGWLRAEHCL 656
                          90       100       110
                  ....*....|....*....|....*....|....*
Feature 1                                            
1KHC_A         68 Alglfsqhf-----nlatfnklVSYRKAMYHTLEK 97
1H3Z_A         69 Pltseaisqf----lekpkpktASLIKAYKMAQST 99
1N27_A         64 Pykeykdk-------fgksnkrKGFNEGLWEIENS 91
2DAQ_A         69 Pyvegdksf-----aegqtsinKTFKKALEEAAKR 98
2GFU_A         83 Pytgskskeaq--kgghfysakPEILRAMQRADEA 115
gi 10719919   287 Ditvnihr--------lhvkrsMGWKKACDELELH 313
gi 156542480  938 PlgvsqelddgkliesrkptdrKAVKKAYQDALLY 972
gi 71297202    62 Pyhahkee-------mikinkgKRFQQAVDAVEEF 89
gi 74762184   445 Kfdcke-----------kqmlvDKAREDYSESIDW 468
gi 15232737   256 Pfrqhfsq-------makqsslPDFIDAIDFALEE 283
gi 62732809   173 Pfcsnftr-------lasqstmSGFVSAVDAALQE 200
gi 53980941   104 Pfeehfre-------kfaqpggRNFPTAIDEAADE 131
gi 145355721  657 Dftehyask-----srdparnkARFQAAVKQANEE 686

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap