Conserved Protein Domain Family
LDH_3

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cd05290: LDH_3 
A subgroup of L-lactate dehydrogenases
L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed of some bacterial LDHs from firmicutes, gammaproteobacteria, and actinobacteria. Vertebrate LDHs are non-allosteric, but some bacterial LDHs are activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenase, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133426
View PSSM: cd05290
Aligned: 9 rows
Threshold Bit Score: 452.554
Threshold Setting Gi: 72494073
Created: 28-Aug-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ###                    # #                                          #####
gi 49035986    6 KIVVIGASNVGSAVANKIADFQLATEVVLIDLNeDKAWGEAKDSSHATsciystNIKFHLGD-YEDCKDANIIVITAGPS 84
gi 28900002    2 KIGVIGAGAVGVGVCNYLLTLGSVSELVLLDQNlERAEGEVFDFRHTAaltfskNTRIIPSDdYLDLLGADIVVITAGAQ 81
gi 50841506    6 HLVVIGIGHVGSDVVTNAAALGLFSRISLIDVDkKVRDGQALDNHQATavapamTTTITAAN-YDACRSADVIIVSAGPS 84
gi 38233041    3 KLVVIGLGHVGSYVLSYAMASGLYAEIATIDTNpGVALGEAIDLAQATgvpgttNTYCHEGT-YADCADADVIICAAGES 81
gi 72494073    3 KLGIIGLGKVGTQVLTDVQQLNLFSEIILIDDRaDVASGEALDHIHSQglintaHIKIRSGV-YQDLTDADFIVIAASEA 81
gi 50843401    7 KLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNeKLAAGQALDQHHATalpnvtNVAVYAGD-YDDLSNADVIIMTAGPS 85
gi 49036092    7 KLVVVGAGMVGSAVLNSVLSLNLLSEVVIIDINdNKAKGEALDASHTTsfayspNVKVRAGN-YEDCADAQIIVITAGPS 85
gi 124523659   5 KLVVAGVGHVGSYVLANAMKLGLFSEIAVLDKKkGVAFGEALDWRHATaltympNTSVKAGD-YSECADADVIICAAGPS 83
gi 88797838    2 KIGVIGAGAVGVGVCHYTLAFGSCSELVLIDQQiGKAEGEMMDFGHANsltfskNIRLRAGDdYSLLTDADIVVITAGAQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                     # #                      #   #     
gi 49035986   85 IRPGETPd-----rLKLAGTNAKIMSSVMGEIVKrt--kEAMIIMITNPLDVATYVVSTqfDYPRNLILGTGTMLETYRF 157
gi 28900002   82 IQQGQTR-------LDIAEINAKIGVEIARKIERva--pKAVLIVVSNPCDIVAHFITTntGFEPNKVISSGCVIDTARL 152
gi 50841506   85 VLPDSYGggh-dsrNSLAQVNSKVIREVMGNICQyt--hSAPIILITNPLDVNVHIAATefDYPTNLVVGTGTALDSARL 161
gi 38233041   82 IVPDPNDptrmpdrSELAQISGAVIRDVMTNITAnvgenPPVLILITNPLDAMVHIAAT--EFGYPKVFGTGTMLDSARL 159
gi 72494073   82 TDKNNGDr------TLLAQGNHDIIKGIMSQIAEvt--qEAVVILISNPVDSMVYFANQi-DYPAHKIIGTGTALETSRF 152
gi 50843401   86 IDASNGPatg-aarRELAATNGKIIRSTMTQITSrn--hDAAIIICSNPLDALVHIASTefDHPQGLVLGTGTILDSARM 162
gi 49036092   86 LKPDDKLd-----rLVLADTNVKVTDSIMKNICKyt--kDAIIIVVTNPVDIATYYCQNnfDYPKNKIIGTGTLLDTARM 158
gi 124523659  84 VLPSEKDemp--drAGLARTNAAVVREVMAGITKyt--kEAVIIFITNPLDTIVYIAENefGYSKGRIFGTGTMLDSARL 159
gi 88797838   82 IKEGQTR-------DDLAEINSRITVDIAQKIETva--pNAILLVVTNPCDIATYFITQntGFPADRVISAGCIIDTARL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #                                                     #   
gi 49035986  158 RRILADKYQVDPKNINGYVLGEHGNAAFVAWSTTGCAGFPiddldeyfhrteklshEAVEQELVQVAYDVINkKGFTNTG 237
gi 28900002  153 MSIVANRVDLDPKNIFGYVLGEHGSHCFTPKSLISIAGQPadyycdth-nieridaDELLEAVKQAGYEIFRrKHNTVHG 231
gi 50841506  162 RRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTlaeattal-glqplspDQVGNSVVQSAFDILEgKGWTSSG 240
gi 38233041  160 RYIIGTELGIDPKSVTGYMMGEHGSTSVPILSQVNVQGLRweeleawh-gkplptaPEMQEKVVRAAYDVLLsKGWTNAG 238
gi 72494073  153 KTIIADHYQIDPNNVEAFVIGEHGQHAIPVWSKVHIHGMElsefeals-drpaidkSHISSIINEVSMDVFYqKGWTNAA 231
gi 50843401  163 CRVVADHLGVDPDYVRGYMIGEHGPSGFPMFTGVNVGGVGfdglaklf-dadpmdrDELTTRINDAGTAVFNlKGWTSAG 241
gi 49036092  159 RKIIGKKYNVDSKNVHGYVLGEHGGSSFTSWSDVNIAGIPfnqlndifkdhykvdkDEVDKEVRDSGIEVLKlKGYTSAG 238
gi 124523659 160 RQLVAENYSIDPKSVTGYMMGEHGFTAFPVFSRLNVQGFRekeldsvfkgkepldrEAFRQKVVKTAFDVLNgKGWTNAG 239
gi 88797838  153 MKLVSEKVDVDPKNVSGYILGEHGSHCFMPWGLVGVAGQPidyycqhn-gfdaidpQTLLEEVKQAGFEIFKrKHNTTHG 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1        #                                                                            
gi 49035986  238 IAMAACRFIKSVLYDEHTILPCSAVLEGeyg-ikDVALSIPRMVCADGIMRSFEVHLTDDELEKMHKAAQSVRSALD 313
gi 28900002  232 IAASVFRIIQAIKINERSVLPVGTMMSGqyg-vsGVVLSLPTVVGKKGAESVLTHPFTEEELETLHSISMNLRSIVE 307
gi 50841506  241 ISKAAVSLARAMLLDQRSIHPVCTLADGvlgfhsEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKLLVSAKAVREVYE 317
gi 38233041  239 VARSANELAKCVLLNERAVHPICTPLHGeyg-leDVSLSIPTEITHEGAGRKMLPQLNEWELEQLHKSAEFIRETVR 314
gi 72494073  232 ISKVTSFLIQSIALDQRTITPLTSLSSEyg--leDGAFSLPTLIDKKGIVQRFAITLDKEEERELKEAYEYIRQTIH 306
gi 50843401  242 IGQSAITIARSILLNEHAVYPVCTTLHGqyghdgDVSMGVPCVIGATGVERILEVPLDDWEQEHLASTIKAIQETVE 318
gi 49036092  239 IAMSVSRLVKAMLLNEQSILPVSSTLEGeyg-inDVALSIPCIITSNGIEKKLEIPLSKDEVEKLNKSADNLKSIIK 314
gi 124523659 240 VAEAAVTLAKAVMLDEKSIYPVSATLHGqygyngDVALSIPSVIGRNGIEQQLEIELDEQETSWLHESAKSIQNTMA 316
gi 88797838  232 IAASVFRMIQAITIDEYSILPVGTLLSGhyg-lsDVVLSLPTIVNARGAHKVLEHPFSETETRELHDIAAALQKLIR 307

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