1Y6J,2V6B,2V6M,1A5Z,1LLD,2E37


Conserved Protein Domain Family
LDH_2

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cd05292: LDH_2 
Click on image for an interactive view with Cn3D
A subgroup of L-lactate dehydrogenases
L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed predominantly of bacterial LDHs and a few fungal LDHs. Bacterial LDHs may be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133428
View PSSM: cd05292
Aligned: 48 rows
Threshold Bit Score: 438.463
Threshold Setting Gi: 211960008
Created: 14-Dec-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ###                    ##   #                                        #  
1Y6J_A         8 SKVAIIGAGFVGASAAFTMALRQTANELVLIDVFKEKAIGEAMDINHGLPFm--GQMSLYAGDYSDVKDCDVIVVTAGAN 85
1A5Z_A         1 MKIGIVGLGRVGSSTAFALLMKGFAREMVLIDVDKKRAEGDALDLIHGTPFt--RRANIYAGDYADLKGSDVVIVAAGVP 78
1LLD_A         8 TKLAVIGAGAVGSTLAFAAAQRGIAREIVLEDIAKERVEAEVLDMQHGSSFy-pTVSIDGSDDPEICRDADMVVITAGPR 86
gi 49035972    2 NRIAVIGVGNVGMAFAYAAAIKRLANDIVLIDANAARAEGESMDLADAMALv--GPVQIRSGGYEQCEGARIVVVTAGAK 79
gi 49035976   21 IKGAIVGAGAVGMAIAYSMLIQNTFDELVLVDIDRRKVEGEVMDLVHGIPFv--EPSVVRAGTLADCRGVDVVVITAGAR 98
gi 50842374   14 SKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFt--PASVMGGADVHDTADSDVVFITAGAR 91
gi 162453521  10 SKVAIVGAGSVGATIAYACLLRGVAKQIALFDVNRAKVGAEVLDLNHGLQFv-pAATLDGSDDVEVCRGADVVVITAGAK 88
gi 209904596   4 NTVGIIGTGNVGMAAAYALFQRQIASSLVLVDKDPRRAEGEAMDLMHGQALv--GRVTVRAGDYADLAGCGVIVICAGVG 81
gi 116672520   4 SKLAVVGAGSVGTSLAYAALIRGSASNIALFDVNALKAEAEVLDLAHGTQFaaaAATVTGGGDIAVTEGADVVVITAGAK 83
gi 184200147  12 TKIGIVGAGSVGTSLAYAAMIRGTSTDIALYDLQTAKVEAEALDLSHGQMFa-pGVRVEGSDDVAVLKDADIIFVTAGAK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                        #                                         
1Y6J_A        86 RKPGETRLDLAKKNVMIAKEVTQNIMKYyNHGVILVVSNPVDIITYMIQKWsgLPVGKVIGSGTVLDSIRFRYLLSEKLG 165
1A5Z_A        79 QKPGETRLQLLGRNARVMKEIARNVSKYaPDSIVIVVTNPVDVLTYFFLKEsgMDPRKVFGSGTVLDTARLRTLIAQHCG 158
1LLD_A        87 QKPGQSRLELVGATVNILKAIMPNLVKVaPNAIYMLITNPVDIATHVAQKLtgLPENQIFGSGTNLDSARLRFLIAQQTG 166
gi 49035972   80 QMPGQSRLDLVRVNAGITRDILTAVMQYaDDPLYIMATNPVDVLTHVARTVtgVAPGRVIGSGTVLDSARFRGHVAEILG 159
gi 49035976   99 QREGETRLSLVQRNVEIFRGLIGEIMEHcPNAILLVVSNPVDVMTYVAMKLagLPPSRVIGSGTVLDTARFRYLLAERLR 178
gi 50842374   92 QKPGQTRLDLAGVNANILRSLMPQLVEQsPNALFVLVTNPCDVLTVVAQEAtgLPANRVFSTGTMLDTSRLRWLIRQWAN 171
gi 162453521  89 QKPGQSRMDLATANVAICRELLPRLLAVaPDALYLLVTNPVDVITYVTLKLtgLPPARVIGSGTVLDSSRFRFLIARQLD 168
gi 209904596  82 QKPGETRLDLLNRNAAVFREIAEQLDRNaPEAVLVIATNPVDILTTVMQRLskRPPEAVIGTGTMLDTSRFRALLGEHYD 161
gi 116672520  84 QAPGQTRLDLAGTNVGILEQLMPQLLQQaPDAVYVLVTNPCDVLTVAAQKIsgLPPERVFSSGTVLDTSRLRWLLARRAG 163
gi 184200147  91 QKPGQTRLDLAGANTAILKSLMPQLVEQaPQAVFVLVTNPCDVLTVVAQQItgLPHQRIMSSGTVLDTSRLRWLIGSEAQ 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            ##          
1Y6J_A       166 VDVKNVHGYIIGEHGDSQLPLWSCTHIAGKNINEYIddp-kcnFTEEDKKKIAEDVKTAGATIIKNKGATYYGIAVSINT 244
1A5Z_A       159 FSPRSVHVYVIGEHGDSEVPVWSGAMIGGIPLQNMCqvc--qkCDSKILENFAEKTKRAAYEIIERKGATHYAIALAVAD 236
1LLD_A       167 VNVKNVHAYIAGEHGDSEVPLWESATIGGVPMSDWTplpghdpLDADKREEIHQEVKNAAYKIINGKGATNYAIGMSGVD 246
gi 49035972  160 VDVRGVHAHIVGEHGDSEVALWSRANVSGIPVAEMCarr-giaYDAAFREKALGHVRHAAYEIIGRKGATGYGIGMSLCR 238
gi 49035976  179 VDPRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEpav-gtpDDPAKMFEVFEHVKNAAYEIIERKGATSWAIGLATTQ 257
gi 50842374  172 VEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAvdg-nrvFTEDVLADLAHEAAYAAYKIIEGKGATNYAIGLTGAR 250
gi 162453521 169 VAVQNVHAYIAGEHGDSEVPLWSSASVANIPLDAWSvpg-hghLGATERAEIFSNVKNAAAQVISGKGATNYAIGLATAK 247
gi 209904596 162 VNPRSVHAYILGEHGDSEVAIWSSASIGGLPIMGHEisc--kpFDAGAMERIFQQVRGAAYDIIARKGYTNTAIGLVIAY 239
gi 116672520 164 VSVASVHASMVGEHGDTEFPVWSGATIGPVPILDWEadg-eriFTPEYLAETAQEVTQAAYKVIAGKGATNYAIGLSGAR 242
gi 184200147 171 VNTSSVHAYIIGEHGDSEFPVWSSASIGQVPLSEWEvdg-hrpFTPERLDELKDQVVNAAYRVIEGKGATNYAIGLAGVR 249
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                                
1Y6J_A       245 IVETLLKNQNTIRTVGTVINGmyg-iedVAISLPSIVNSEGVQEVLQFNLTPEEEEALRFSAEQVKKVLNEV 315
1A5Z_A       237 IVESIFFDEKRVLTLSVYLEDylg-vkdLCISVPVTLGKHGVERILELNLNEEELEAFRKSASILKNAINEI 307
1LLD_A       247 IIEAVLHDTNRILPVSSMLKDfhg-isdICMSVPTLLNRQGVNNTINTPVSDKELAALKRSAETLKETAAQF 317
gi 49035972  239 IVEAILHDEHSVLTVSCPVAGhyg-lgdVSLSLPCVIGSDGIEEVLDAPIAEDEQAALAASARVLGEHLAAL 309
gi 49035976  258 IVRAITRNQNRVLPVSVLMSGlhg-ieeVCLAYPAVLNRQGIDRLVKFSLSPGEEEQLQRSARVMRQTLDGI 328
gi 50842374  251 LAEALLRPGRSVLPLSSVMTDmhg-isgVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASAERLHDTLSSI 321
gi 162453521 248 ILEALLRDENRVLPVSSLLSGyrg-iddVCLSVPCIVNRSGVESQLPIPMSSEEEAGVRASADTIRKAIRSL 318
gi 209904596 240 LVRVILEDQKSVLPVSVDPAGiygiepgLCLSIPCVVGSRGVECRVPPEVSEQERAGLHASAAVLRGGLEGM 311
gi 116672520 243 IVEALLRDENAVLPVSTVLDGpyg-isgVALSLPSVVGRGGVHRILHTPMDDGELAALQHSADTLRNTMGTL 313
gi 184200147 250 IAEAVLKDQQSVLSVSTVLEDyyg-vsgVALSVPSVVGGTGVGQQLRIPMGEPEKQQLRASAETMRASLRDL 320

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