2I1A


Conserved Protein Domain Family
RP_DDI

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cd05479: RP_DDI 
Click on image for an interactive view with Cn3D
RP_DDI; retropepsin-like domain of DNA damage inducible protein.
The family represents the retropepsin-like domain of DNA damage inducible protein. DNA damage inducible protein has a retropepsin-like domain and an amino-terminal ubiquitin-like domain and/or a UBA (ubiquitin-associated) domain. This CD represents the retropepsin-like domain of DDI.
Statistics
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PSSM-Id: 133146
View PSSM: cd05479
Aligned: 32 rows
Threshold Bit Score: 155.788
Threshold Setting Gi: 169800048
Created: 15-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic motifCatalytic
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:conserved catalytic motif DT/SG of retropepsin.
  • Citation:PMID 7664111

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        ###                                             
2I1A_A        11 RNAIEYTPEMFTQVPMLYINIEINnYPVKAFVDTGAQTTIMSTRLAKKTglsRMIDKRFIGEARGVGt-GKIIGRIHQAQ 89
gi 71030112  183 MSAQNYFPESFGRIVMLYIKVEINnVVVKALVDTGAQNTIMSKECALQCnllSLVDERFKGVAVGVGs-TKTLGKIHLAD 261
gi 70798972   26 ANALEYTPEAFAKVTMLYVPCTINqVLVKAFVDSGAQNSIMNKRTAERCglmRLVDVRMRGVAVGVGr-QEICGRIHMTP 104
gi 71744436  150 ANALEFAPEAFTRVSMLHVTVEINkVKVKALVDCGAQTSVVSAATAERCginWLVDKRAVGTVHGVGe-QRSLGRIHLTQ 228
gi 71666815  216 ESAYEFMPELFVRVPMLFVNCEVNkVMVKAFIDSGAQRSIMNLRTAEKCglmRLLDTRAKGIMRGVGv-RRTLGVVHMAM 294
gi 158594351 207 QFAMEHMPEAYIPVSMLYIKMKINgVEVKAFVDSGAQVSILSDSVAQRCnlmRLVDQRFQATVHGVGgaQQLLGKIHACQ 286
gi 123483572 108 QYAYENNPENFIVYSSPFIKCSINgVEVVALIDTGAQSSIIPHALAKKCnvkYLIDARYRTLTKGVGm-QTSKGVIHGLN 186
gi 159119790  98 EINKYYPGLLVNAVPSLYIRVSINgTPVVCVIDTGAEFNSMGRKTARACgleGHIDTRYAGRAIGVGs-TRMLGRIHICL 176
gi 159118697 105 QVYDHYPELLVNNTNSVYIHIELNgHPDIAVIDTGAEFSTISLETAIRCgleDHIDKRQEGKALGIGs-SKIVGKIHLVQ 183
gi 169800048  24 KVLEKEHPELLVKGELVFIKVKINgVVKEAMIDCGAQETVISIRACKECnleTQIDYRVKKMYQGVGr-METIGVIHLVP 102
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
2I1A_A        90 VKIETQYIPCSFTVLdt---diDVLIGLDMLKRHLACVDLKENVLRI 133
gi 71030112  262 MKIGSIFIPVSFIVIdga--nlEFILGLDILRRYTCDINLKYNYLGI 306
gi 70798972  105 VNLAGMYIPFAFYVIedq--amDLIIGLDQLKRHQMMIDLKHNCLTI 149
gi 71744436  229 ANLGGLFIPISLVVLese--tfDLIIGLDQMKKHRMIIDLKDDCLRV 273
gi 71666815  295 VNLGGLHIPLSLSIIedd--kmEFIIGLDQLKLHRMIIDLRENCLRI 339
gi 158594351 287 VQIEEQFFSCNFDVLanr--diDVLLGLDILKRHRCVIDLQINCLRF 331
gi 123483572 187 VKVGNEVWTNRFVVLddt--ldHAILGIDWLKKNRALIDLAQNCLIL 231
gi 159119790 177 MQCGDIFLPMNFAVLds---vcDTLIGMSALSMYRAMIDLSSFSMTL 220
gi 159118697 184 LKYGDEYFATNFMVVen---vvGTLLGMPFLRMHRMVIDLAIYQIRI 227
gi 169800048 103 IIIGNTYCITTLNVLgddspldHLLIGTNTLKSIGAVIDFSEGVLRI 149

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