Conserved Protein Domain Family
retropepsin_like_bacteria

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cd05483: retropepsin_like_bacteria 
Bacterial aspartate proteases, retropepsin-like protease family.
This family of bacteria aspartate proteases is a subfamily of retropepsin-like protease family, which includes enzymes from retrovirus and retrotransposons. While fungal and mammalian pepsin-like aspartate proteases are bilobal proteins with structurally related N- and C-termini, this family of bacteria aspartate proteases is half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate proteases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.
Statistics
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PSSM-Id: 133150
View PSSM: cd05483
Aligned: 184 rows
Threshold Bit Score: 50.7057
Threshold Setting Gi: 88705389
Created: 17-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
catalytic motifCatalytic
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:conserved catalytic motif DT/SG of retropepsin.
  • Citation:PMID 7664111

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             ###                                                        
gi 62195942  123 GHFEVNGRVn---gARVHFLVDTGASSVVLSQedaeragid--taslnysvPIMTANGQARAASit--iATLQIGdi-er 194
gi 114799445 178 GIKQVAITId---gVPVLADFDLGNGNEILLSrefaeragllepanilgtkLGGGIGGPVERTLvr--vETLEIGgh-vl 251
gi 167752906 187 HNFYTDITIg---gRTERFIFDTGCSGASFVSaefakrhd---leiicdsiSVSGIGGNGFVKFat--tDSMQIGpv-ti 257
gi 88810660   23 ATYYVPVSIag--wGTGDFLVDTGASHMAINQaalnslkandqadyikhliGTLADGGQITVPVyr--iASVMIGqdcvl 98
gi 153808124 183 TTILIPVTIn---gKTYRFIFDTGAGTSFMSErfakevgv---rmlndsltINSTLPGAMNGQMgt--vENMQIGsm-if 253
gi 149919794 449 DVIILEIKAd---dATLRMLFDTGASDLLMSDqqahs---------lvigtDAMAPLAAGGPNLpqgqlESLGLGdm-tv 515
gi 56478001   36 TTFYVQGKIgg--lGTVDLMVDTGSGYMTINEemlatlqga-gqaqyirqlRGRLANGSELDVPvy-aiKAVSIGdgcwl 111
gi 83643367   52 NKLFVEVEVg---gAPRRFVFDTGSPSMMSAKlakelgl------kvidkrKGRDSHGAIVESEiv--qADLNVGgt-vf 119
gi 151572019  42 QEFIAPYLIakvnqNKAYILFDSGSKGVSIFNssvtqlkl---nksqdsnySLNMAGQKSKNHSvi--lDEIEIGni-hl 115
gi 167627951  44 KAPYILAKVn---nRFAYVIFDSGSKGISIFNhsvdqlgl---nqesgsgySSNMVGQKIKNQNvv--lNKIQIGdi-ll 114
                         90       100       110
                 ....*....|....*....|....*....|
Feature 1                                      
gi 62195942  195 HNVRAMVTKegl------ltgSLLGMNFLQ 218
gi 114799445 252 RNVTAAVSPpgd------gadANIGVSVLR 275
gi 167752906 258 RHPYFMVFDndeasdqighieAVLGTDFMR 287
gi 88810660   99 TNVEAAVFPgq--------trNILGLSALR 120
gi 153808124 254 HYPLITVAPpnalds-vmrvdAILGMDFIN 282
gi 149919794 516 KNVPVTMFPadq-------lgAVVGMTGVD 538
gi 56478001  112 NNVEAAVFPgk--------trAILGLNALQ 133
gi 83643367  120 HKTPLFVADfpkta--qclfdGVLGSEVLP 147
gi 151572019 116 NNIKARVTTqpkkk---qypiIVIGLDFLE 142
gi 167627951 115 KNVEAKITNqpkrk---qypvIVVGTDFLV 141

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