Conserved Protein Domain Family
Bromo_ZMYND11

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cd05492: Bromo_ZMYND11 
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99924
View PSSM: cd05492
Aligned: 10 rows
Threshold Bit Score: 144.831
Threshold Setting Gi: 114629039
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                   #  #                    
gi 68438063  264 MTTYLKFILGRMKe--------------RAVNLHKRGQea---------------kQPIYQRLIHTLLDVENIQENISDg 314
gi 34190262  118 MGTYLRFIVSRMKe--------------RAIDLNKKGKdn---------------kHPMYRRLVHSAVDVPTIQEKVNEg 168
gi 50732273  158 MSTYLRFIVSRMKe--------------RAIDLNKKGKdn---------------kHPMYRRLVHSAVDVPTIQEKVNEg 208
gi 54636105  234 LSCLLQYSWSKHQswlrt------dvdiDMKSLSSRDRa-----------------LVKRVLFKSNTLGQADIQKNIESk 290
gi 7303438   243 LGCLLKYSWDQHHswism-----dvakyMAKHWNERDKa-----------------LVKRLLFKTKILGLGDIERNIAAa 300
gi 156717862 158 MGKYMRFIVSRMKe--------------RAIELNKKGKds---------------kHPMYRRLVHTTIDVSTINEKVTEg 208
gi 118782130 170 LNYLLKFVVEQYKswflr------dtarQTPVVTRKTI------------------DICRKMLLRIPTSFADVREKITSe 225
gi 66548728  143 LNHILSFTCGHLKaklpp------eitnRTIVFNNDPIvtpanrysgttwisegedAWRPGVLIKHHMDLAIMDTKIKKn 216
gi 91081987  217 LNYLLKFVIHRIQswlp-------htltHTMAQQERPEwltd-----------kelSWRANQLFFEHRDMSVIEVNLNNe 278
gi 114629039 113 LICDLCFRVYHSKclsdefrlrdssspwQCPVCRSIKKk----------------nTNKQEMGTYLRFIVSRMKERKVNe 176
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1                           #   #     #                     
gi 68438063  315 -KYKSFEEFKADAQLIVHNTAILHGVnSDQTEIARLLYNDTCHELNELMLC 364
gi 34190262  169 -KYRSYEEFKADAQLLLHNTVIFYGAdSEQADIARMLYKDTCHELDELQLC 218
gi 50732273  209 -KYRSYEEFKADAQLLLHNTVIFYGAdSEQADIARMLYKDTCHELDELQLC 258
gi 54636105  291 -KYTYLTEFFVDLLDLQHNIGVFFGHtEQPYNATQWLMRDVTHDIREIRRC 340
gi 7303438   301 -KYTYLTEFLMDLLDLQHNMAVFFGQkSVEYNATKWLMRDVTHDIREIRRC 350
gi 156717862 209 -KYKSYDEFKADAQLLLHNTIIFYGDdSEQADVAKVLYKDTCHELDELQLC 258
gi 118782130 226 -QYARLEEFHVDLLDIVHNVAIIHGDtSTAYSAAMYFLADCVYDLREIRHC 275
gi 66548728  217 -EYNNLAEFQADAHNILHNIIIYHGThSIIGEMGHTMYQDCCYDLQEIRRC 266
gi 91081987  279 -SYTKLYQFLADVLTIQHNVAIFHGIeSQEYGAAELMIRDCMHDLTELKLC 328
gi 114629039 177 gKYRSYEEFKADAQLLLHNTVIFYGAdSEQADIARMLYKDTCHELDELQLC 227

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