Conserved Protein Domain Family
Bromo_ALL-1

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cd05493: Bromo_ALL-1 
Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99925
View PSSM: cd05493
Aligned: 9 rows
Threshold Bit Score: 134.485
Threshold Setting Gi: 115968092
Created: 14-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #             #  #         
gi 146345435 1647 VLTALLNSRTTSHLLRYrq----------aaKPPDLNPETEESIPSRSSPEGPDpp---------vlTEVSKQDDQQPLD 1707
gi 50760091  1822 VLTALLNSRTTSHLLRYrq----------aaKPPDLNPETEESIPSRSSPEGPDpp---------vlTEVSKQEEQQPLD 1882
gi 118101944 1532 CDKCYDDDDYESKMMQCg-------------KCDRWVHSKCENLSGFNSPVEFEny----------qPPAALQTGIPNLS 1588
gi 115968092 2083 EAETVSESETKVSIVSPeavpd-----vdpnIPDAVLEVTTSTQPEQDASKTPAkvvtie--igkkeEEEKKEEEIKPTS 2155
gi 122066749 1380 EDYEILSGLPDSVLYTCg------------pCAGATQPRWREALSGALQGGLRQvlq-------gllSSKVAGPLLLCTQ 1440
gi 125838356   37 GWRELLDQELRTGLERL--------------LSCMMGSTVTQHLVTCKKCSTLG-------------SSNIGVEELPICD 89
gi 148725853  225 LHEILCRLRGKSLVFSCapcsksfcsgwqdvVQEVLRNGLEKIMGGLKNSLNIShlrlca--qceacPDFEVVKGRSGCC 302
gi 156353194  157 CLSDLPDSIPFVCKLCCq------------eENPKWLQEMQEEMQAGYQRVIDEvessrgyqpligyFSQVEFENGTPKD 224
gi 160333334 1841 VLTALFNSRTSTHLLRYrqa---------vmKPPELNPETEESLPSRRSPEGPDpp----------vLTEVSPPNDSPLD 1901
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                #   #                         #          
gi 146345435 1708 LEGVKRKMDQG----------NYTSVLEFSDDIVKIIQAAINSDGGQPEIKKA--------NSMVKSFFIRQMERVFPWF 1769
gi 50760091  1883 MEGVKRKMDQG----------GYVSVLDFSDDIVKIIQAAINSDGGQPEIKKA--------NSMVKSFFIRQMERVFPWF 1944
gi 118101944 1589 LFRVNEDLYAYecare-yivgSILTSLDFSDDIVKIIQAAINSDGGQPEIKKA--------NSMVKSFFIRVVPENGFEV 1659
gi 115968092 2156 FQFVKAKMMAG----------YYKSVEKFTKDCVTIFQASFNQETSLIPGLSKs-------NVIAKGAFFKIMIQMFPWF 2218
gi 122066749 1441 CGQDGKQLHPGpcdlqavgkrFEEGLYKSVHSFMEDVVAILMRHSEEGETPERr------aGSQMKGLLLKLLESAFCWF 1514
gi 125838356   90 LSAIGKKFEGG----------HYTSLKSFHEDVVKVLRRYLEEEEVLPEDQKH--------TALARSYYLTLLEDVYGWF 151
gi 148725853  303 LHPVEKKLENG----------LYTSLKSFHEDVVKVMVERLRREEYLLEAQRP--------TSQAKLYYIKLVEQVFSWF 364
gi 156353194  225 LDAVRAKVKEN----------AYRVVGDFCHDMLLILNKVCKITGNQPLVRNAavlyevfiKEVGAMFPWHKIKSVQDST 294
gi 160333334 1902 LESVEKKMDSG----------CYKSVLEFSDDIVKIIQTAFNSDGGQLESRKA--------NSMLKSFFIRQMERIFPWY 1963

                  ....*...
Feature 1                 
gi 146345435 1770 SVKKSRFW 1777
gi 50760091  1945 SVKKSRFW 1952
gi 118101944 1660 LRRVFVDF 1667
gi 115968092 2219 NIEDTRLW 2226
gi 122066749 1515 DAHDPKYW 1522
gi 125838356  152 NSQDPKLW 159
gi 148725853  365 NSQDPKTW 372
gi 156353194  295 TTETVKPE 302
gi 160333334 1964 KVKESKFW 1971

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