Conserved Protein Domain Family
Bromodomain_1

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cd05494: Bromodomain_1 
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99926
View PSSM: cd05494
Aligned: 10 rows
Threshold Bit Score: 78.6398
Threshold Setting Gi: 74181165
Created: 16-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89041611   139 DDEELKRVLRSLQMrah-------------kmAQPFLEPVDP-------------------NDAPDYYGVIKEPVAAAAP 186
gi 110757424  881 IYEKEEISLRELRIflreica----klarnrqFFMFTKPVDT-------------------EEVPDYIYVVCKSININNK 937
gi 145610761  327 LYEAAEKVLSELKAht--------------eySTPFLSRVNK-------------------RDAPDYYNRRKLRSSFHSS 373
gi 147832750  889 DKEELKAALVVIKKvmk------------mdaAEPFNVPVNPv-----------------eLGIPDYFDVIDTPMDFGTI 939
gi 47221861   725 DYTALYKVLEALKShk---------------dAWPFLEPVDE-------------------SYAPNYHDIIKHRMVDGRH 770
gi 12321252   212 NKQELEDSLIVIKKimk------------meaADPFNVPVNPe-----------------aLGIPDYFDIIKTPMDFGTI 262
gi 125602458  235 YKEALSWFEQECQRle---------------pPMPLALPPPPqppvpmpmqappriggggrRPKPKAREPNKREMSDEEK 299
gi 114689071   54 DGAAGQRCSSPPRRgrgraevlltsqagrhgrGAPHISDDGRpgr--------------daSHFLDGMAAGKRRSSLPRW 119
gi 74181165  1344 NLEEMEEEVRLKKRkrrr-----------nvdKDPVKEDVEKak---------------krRGRPPAEKLSPNPPKLTKQ 1397
gi 125851595 1065 DLTYCEIILMEMEAhs---------------dAWPFLEPVNP-------------------RMVPGYRRIIKNPMDFLTM 1110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89041611   187 QQSIPWt------------EMASQDLEQSCRKLPSLMLEESRTNMWTRkkktsgvsev------------qavhlvqpvp 242
gi 110757424  938 VKVHTDihvvcfhvslrdrPSLGILKRDPADKLIRHRACSLRDNAYALika--------------------------eld 991
gi 145610761  374 PNIIVRpraev----eaeeRRKQNGGEDDAGDDSDDEPIMSSRGRIAGskgtn----------------------ksrka 427
gi 147832750  940 CDNLEKdaape---qdsvlEGLPPEGPSVRDKAIVATGRKTDMLASKEeivetssingfgs------iqaedfvpssqgk 1010
gi 47221861   771 VGPRYPm-----------gHDPNHQQPQHQQQPPYMGPTHGPSLGPRPmalqpg--------------------pppeas 819
gi 12321252   263 CNNFEK-------------GNKYMNSEDVYKDVNYIWNNCSKYNKKGDy------------------------------- 298
gi 125602458  300 HKLRVEignlp---eekmgNVLQIVQKRNTDPALMGEVVELDFDEMDVetl--------------------------wel 350
gi 114689071  120 DGGQVEt-----------lLTFQSGQPGRGAPQIPDDGRPGPESQYTKta----------------------------qe 160
gi 74181165  1398 MNAIIDtvi--------nyKDRCNVEKVPCNSQLEIEGNRSESVIISIgawetwrktscfsvtthrhstwkdprstktpl 1469
gi 125851595 1111 RERLLQggd-------ialSHTLKMAEVKQQETEDMIVTRDCQSILAVls----------------------------ti 1155
                         170
                  ....*....|....*.
gi 89041611   243 IHQQGHQPDARAQHVH 258
gi 110757424  992 SDFEDKCREISKNRRI 1007
gi 145610761  428 PSDQQEQAPGTDTKPV 443
gi 147832750 1011 IHIKSSQLKNKKQKRH 1026
gi 47221861   820 MYPSHHHPEGLNMHHM 835
gi 12321252   299 IVDLMKRVKKNFMKYW 314
gi 125602458  351 DRFVVNCKKALSKSRR 366
gi 114689071  161 IVNVCYQTLTEYDEHL 176
gi 74181165  1470 SYSQCLRVLGRKLPKK 1485
gi 125851595 1156 VFVNLKGMFMQCRDLP 1171
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