Conserved Protein Domain Family
Bromo_Brdt_II_like

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cd05498: Bromo_Brdt_II_like 
Click on image for an interactive view with Cn3D
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99930
View PSSM: cd05498
Aligned: 27 rows
Threshold Bit Score: 164.759
Threshold Setting Gi: 85105579
Created: 17-Sep-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #      #  #                                      #   
2OO1_A          8 HLRYCDSILREMLskkhaayAWPFYKPVdaealeLHDYHDIIKHPMDLSTVKRKMDgreYPDAQGFAADVRLMFSNCYKY 87
gi 15967128   262 SMKPCLKLLNDFStkkyqefAWPFNEPVdaeqlgLHDYHKIIKEPMDLKSMKAKMEsgaYKEPSDFEHDVRLMLRNCFLY 341
gi 22265870   556 WQKFCSKLLNEIHsvknkgfAQVFYLPVdpiklkIYDYLEVITNPMDLQTIKKKLDfkqYAEPEEFVHDINLMVDNCCKY 635
gi 54635558     2 ESNACKAIIRKLFssqykklAWIFYEPIdapylgLHDYHKIVKKPMDLNSIRTRLQaglYVNADEFVRDVRLMFDNTYLY 81
gi 158596511  217 QMKFCQRLVNELFtkkcksfTWPFLEPVdveglkLEDYYDIVKNPMDLGTIRRKLDakqYATPEELRADVILICENCYKY 296
gi 4581512    256 QMRFCSTVLKELYkrqyesfAFPFYQPVdpvacdCPDYFDVIKEPMDLSTIQSKLNkneYSTLEEFESDILLMFNNCFTY 335
gi 9955810    393 EMKFCQSVLKELLkkqheayAYPFYKPVnptacgCPDYFKVIKHPMDLGTMQNKLNhneYASMKAFEADMVLMFKNCYKF 472
gi 19171078    16 QLKYCSQILTRLKrn---snAPPFLEPVdpvklgIPDYPEKIKHPMDLSTIRKKLDskeYEGPEGFDGDMRLMFSNCYTY 92
gi 116510412 1032 QFKFCSKLLNDLFkkqyyniAHPFYEPVdwvrmeIPSYPKIIKKPMDMSTMRKKLDngeYATPQKFAEDFRLMLRNCSTF 1111
gi 63054449   256 QMRFCSTVLKELYkrqyesfAFPFYQPVdpvacdCPDYFDVIKEPMDLSTIQSKLNkneYSTLEEFESDILLMFNNCFTY 335
                          90       100
                  ....*....|....*....|..
Feature 1         #     #               
2OO1_A         88 NPpdheVVAMARKLQDVFEMRF 109
gi 15967128   342 NPvgdpVHSFGLRFQEVFDRRW 363
gi 22265870   636 NPkgspAHSNALELRSFFEQRW 657
gi 54635558    82 TTpdhlCHQMAKKLQAIFEAMF 103
gi 158596511  297 NPtsdpIHQHGRALQKYFEDKW 318
gi 4581512    336 NPpgtpVHVMGRQLENVFKEKW 357
gi 9955810    473 NSagtpVHLMGKKLESIFQKLW 494
gi 19171078    93 NPpgtvVHEMGKGLEAVYTDLM 114
gi 116510412 1112 NPvgtpVCTAGQQLGRVFEEKW 1133
gi 63054449   336 NPpgtpVHVMGRQLENVFKEKW 357

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