Conserved Protein Domain Family
Bromo_BDF1_2_I

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cd05500: Bromo_BDF1_2_I 
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99932
View PSSM: cd05500
Aligned: 14 rows
Threshold Bit Score: 157.09
Threshold Setting Gi: 71018707
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #      #  #                                        
gi 5921175    149 IPKHQQKHALLAIKAVK-RLKDARPFLQPVDPvkLDIPFYFNYIKRPMDLSTIERKLNvg-------------------- 207
gi 71018707   105 ISAAQLKFAQSTLKSLK-TRREAIAFLAPVDPvaLGIPQYPQIITKPMDFGTIDIKLAltalvlkpnskpgdkaksapqw 183
gi 50553560   121 MPKHQVKYAASSLKAVK-RLKDAAPFIHPVDPvkLNIPTYFEVIKHPMDLGTMEKKLNng-------------------- 179
gi 57229792   717 LTLTQHKYMLNAVRSLKkRLPDAYNFLVPVDTvrFNIPHYHTVIDTPMDLGTVETKLIvsdprgppkdks-------kms 789
gi 90306475   253 ITPLQNKFFIRTLAALK-RTHDARFFRVPVDPvkLNIPNYPTIIKEPMDLHTMEDKIKsg-------------------- 311
gi 1431082    134 LPPHQSKYLLSSIKATK-RLKDARPFLKPVDPiaLNIPHYFNYVQTPMDLSLIETKLQgn-------------------- 192
gi 154287696   74 LTAKQSKFLVRCIQGLK-RVHDSRFFREPVDPvkLNIPNYPLIIKQPMDLRTIEEKLKag-------------------- 132
gi 116510412  826 MSLAQWKYCGSCIRSLK-KLKDSIPFLKPVDPvqLNIPHYPSIIKHPMDFSTIERKLNssnpvkpd-------------- 890
gi 146421118   93 IPKHQAKFALNSIKTIK-RLRDAAPFTVPVDTvkLNIPLYYNYIKRPMDLSTIERKINln-------------------- 151
gi 63054449    85 MPPPQQKYCLAIVRQLK-RTKNSAPFKVPVDPikQNIPDYPTIVKNPMDLGTIEKKLTsy-------------------- 143
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
Feature 1                                  #   #     #               
gi 5921175    208 -------aYEVPEQITEDFNLMVNNSIKFNGpnagISQMARNIQASFEKHM 251
gi 71018707   184 gldpakdvYRRMHDFEADVRQVFFNCATFNGpdspYTHNARVLEAAFDKYM 234
gi 50553560   180 -------eYGTKEDMIADVQRIVDNCLTFNGadsfISSMAKSLFTSFERHM 223
gi 57229792   790 kwdtskgkYNNVAEVTEDVRRIWENSRKFNGkehpVSQMATRLEEAFERSL 840
gi 90306475   312 -------aYKTVDQITADFKLMIDNCITFNGpehvVTVEGMRLRDNWERHL 355
gi 1431082    193 -------vYHSVEQVTSDFKTMVDNCLNFNGpessISSMAKRIQKYFEKKL 236
gi 154287696  133 -------sYTSLFAVTSDFDLMVDNSVTFNGpehvVSMEGANLKQSFERHL 176
gi 116510412  891 -pnpdnprYLTVEDFVSDVRLVFTNCLTFNGpdhvVTQMGKRVEQVFDKHL 940
gi 146421118  152 -------aYADVSEIVDDFTLMVDNCCRFNGrrlpLYHKWLRISRAISKSI 195
gi 63054449   144 -------eYSVPQEFIDDMNLMFSNCFLYNGtespVGSMGKALQEVFERQL 187

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