Conserved Protein Domain Family
Bromo_SP100C_like

?
cd05501: Bromo_SP100C_like 
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
?
PSSM-Id: 99933
View PSSM: cd05501
Aligned: 6 rows
Threshold Bit Score: 157.975
Threshold Setting Gi: 110760414
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #           #  #                             
gi 6166538    757 PEEQLKCEFLLLKVYCC---------SESSFFAKIPyy-------yyIREACQGLKEPMWLDKIKKRLNEhGYPQVEGFV 820
gi 13991103   773 PEEQLKCEFLLLKVYCD---------SKSCFFASEPy---------yNREGSQGPQKPMWLNKVKTSLNEqTYTRVEGFV 834
gi 26350431   474 QTRRQKCELLLLTIYCY---------PKSGFFIPKPk---------qRKEKFPDLREHMWLNKIKNRLNKkAYHSVRRFV 535
gi 110825744  568 KRMLWSCTFCRMKRSSG---------SQQCHHVSKTlerqmqpqdqlIRDYGEPFQEAMWLDLVKERLIT-EMYTVAWFV 637
gi 149411491  997 PEELLKCEFLLLKIFCL---------YDSKIFIEDPe---------rIKDYYQHIKEPMWLNLIKERLHQgMYNTIEGFV 1058
gi 110760414 1473 PLALSKLEMIHQTVWQMdeaevfkcpSSGGNNQSSTy---------tIEDYCKVIKSPMFLETVEYKLKNrVYHKVEHVV 1543
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
Feature 1                  #   #     #                     
gi 6166538    821 QDMRLIFQNHRASYKyk-gFGQMGFRLEAEFEKNFKEVFAI 860
gi 13991103   835 QDMRLIFHNHKEFYRed-kFTRLGIQVQDIFEKNFRNIFAI 874
gi 26350431   536 EDMRLIFHNHSIFYKk--rFKNLGIIVGKKFEKNFKRIFSI 574
gi 110825744  638 RDMRLMFRNHKTFYKas-dFGQVGLDLEAEFEKDLKDVLGF 677
gi 149411491 1059 LDMRLIFKNCWKFNKnn-kFGQMGIKLKKVFEKNFKQVFSI 1098
gi 110760414 1544 RDFRRIVYNSKLYHKddhdRVKVIETLSKKLEELFEEHFAS 1584

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap