Conserved Protein Domain Family
Bromo_tif1_like

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cd05502: Bromo_tif1_like 
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99934
View PSSM: cd05502
Aligned: 20 rows
Threshold Bit Score: 153.986
Threshold Setting Gi: 83405105
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #   #  #                                         # 
gi 50747778  1119 LDDYDQKKCEKLVLSLFCS-SMSLPFHEPVSpLARHYYQIIKRPMDLSIIRKKLQkkdkfHYSAPEELVTDVRLMFWNCA 1197
gi 55962792   264 LSACDQRKCEKLTLLILSN-ILSAPFHEPVSpLARHYYQIIKKPMDLSVIRNRLGsnshtHYCSPQEFVADVLLMFKNCA 342
gi 47220585    73 LSNQEQRRCEKLALRLYSH-ALSAPFHEPVSpLAQNYYQIIRRPIDLSLIRRRLDetntlHYFSVEQFIDDVLLMFKNCA 151
gi 156402732   72 QTFISLQICEKILLELFCH-SDSIPFQQKVSkSVPNYYKVITHPMDLSTIRAKIQpqhfqHYSSITEFLSDCQLIFSNCA 150
gi 92081546  1000 LQGKPLKLCERILLELFCH-SKSSPFHFPVKnSVPNYYKLIKEPMDFLKIKKKLQpgnfqHYAGCEKFLSDVYLVFTNCY 1078
gi 156554524  945 MSTRDLRIAQRIVLELYCQyEQSLPFREVVPpEIVEYHRVIKKPIALDVIKEKLKpesenHYTDLKQVIADIRLMFKNAY 1024
gi 6631000    963 LSALELRILQRICLELYCQyEQSLNFREPESpANTSYYEIVSSPMSLDVIRTRLDpsspnHYKDIAGFVSDVRLIFSNTY 1042
gi 91080215   668 LCYKDKKIAERIVLELYCQyDPSLPFREVIGpENEEYHAIIKTPIALDSIRQKLNwnspeHYTTMEQLIKDVRLMFKNAY 747
gi 108876507  872 ITPLELKILQRIILELFCQyETSMPFRHLEPeINKAYYDIVCNPISLTMIRDKLEmtnpgHYTDIASFVADIRRLFSNVY 951
gi 115757074 1184 FTAREFKLCQRLLLEMYCL-EDSQPFLEPVGpEVTGYLEIIPIPMDLSTIKSKLSltspnKYFSPRQMVEDLRVMFTNCY 1262
                          90       100       110
                  ....*....|....*....|....*....|
Feature 1           #     #                     
gi 50747778  1198 KFNYpdseVAEAGRCLDVFFEGKLKEIYPD 1227
gi 55962792   343 KFNYpdseVAQAGHSLQSFFISKLREVFPD 372
gi 47220585   152 TFNYpdseVAQAGQNLETFFLNQLKEVFPE 181
gi 156402732  151 TFNDesseVGRMGNNLELYYMSLLQKFLPE 180
gi 92081546  1079 LFNGedtsLGRAAKEVQKYFYERVQLWLPF 1108
gi 156554524 1025 TFNPpesqVFHEAKSLDYFFEKLLTKWAEN 1054
gi 6631000   1043 LFYQedtkTYSNAKYLENFFEEQLAKWLPQ 1072
gi 91080215   748 TYNPedsqVYADAKVLEKFFDEQLEKFLPE 777
gi 108876507  952 LFYQedsiTFKNAHKLEKFFEQQLAKWLPK 981
gi 115757074 1263 QYNGetsdLGKIAQHLQRYASRFMKRYLPE 1292

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