Conserved Protein Domain Family
Bromo_BAZ2A_B_like

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cd05503: Bromo_BAZ2A_B_like 
Click on image for an interactive view with Cn3D
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99935
View PSSM: cd05503
Aligned: 13 rows
Threshold Bit Score: 180.263
Threshold Setting Gi: 115698917
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 #    #  #                                               
2E7O_A         11 DLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSsg---------qYPNLETFALDVRLVFDN 81
gi 34391523  1590 DLTFCEIILMELESHEDAWPFLEPVNPRLVPGYRKIIKNPMDFSTMRHKLLng---------nYSRCEEFAEDAELIFSN 1660
gi 47229311  1351 DLTFCEIILMEMEAHADAWPFLEPVNPRLVPGYRRIIKNPMDFPHHEGAAAagrvsppsdrpaYNSCEEFAADAQLVFNN 1430
gi 45382753  2027 DLAICSMILSELETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIRDKLTsg---------qYPNVEAFSLDVRLVFDN 2097
gi 30794571  1264 NKELCQLMLDELVVQANALPFLEPVNPKLVPGYKMIISKPMDLKTIRQKNEkl---------iYETPEDFAEDIELMFAN 1334
gi 21627440   579 ELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQdl---------sYKTREDFCVDVRQIFDN 649
gi 109939729 1771 DLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLrg---------gYTSSEEFAADALLVFDN 1841
gi 156394527  214 DMAPCRTILAEMEKHDDAWPFLIPVNAKQFPEYYKIIRKPMDFHTMKIKLRdy---------qYSSPQEFAQDSRLVFAN 284
gi 24652776   356 ELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQdl---------sYKTREDFCVDVRQIFDN 426
gi 22653668  1869 DLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSsg---------qYPNLETFALDVRLVFDN 1939
gi 148922865  341 DLGLCRILLAELERHQDAWPFLNPVNLKSVPGYRKVIKKPMDFSTIREKLVss---------qYQNLETFIIDVNLVFDN 411
gi 115698917 2141 ELQPCKQILGEIEKEQNSWPFMAPVNTKQIPTYRKIIKQPMDFSTMKSKLKek---------kYKTLDEFAGDARLIFDN 2211
gi 158591872 1462 MKNLFNTMLDELWARPESGPFQYPVDTKEVPFYKKVIKRPMDLNQIRMNVEnn---------kYMTQESFIEDLEQIFEN 1532
                          90       100
                  ....*....|....*....|....*.
Feature 1         #   #     #               
2E7O_A         82 CETFNEDDSDIGRAGHNMRKYFEKKW 107
gi 34391523  1661 CQLFNEDESDVGKAGLILKKFYDARW 1686
gi 47229311  1431 CELFNEDTSEVGVAGHAMRRFFESRW 1456
gi 45382753  2098 CETFNEDDSDIGRAGHNMRKYFEKKW 2123
gi 30794571  1335 CRQFNIDHSEIGRAGISLHKFFQKRW 1360
gi 21627440   650 CEMFNEDDSPVGKAGHGMRKFFESRW 675
gi 109939729 1842 CQTFNEDDSEVGKAGHIMRRFFESRW 1867
gi 156394527  285 CEEFNEDDSEVGQAGKRLSKFFESRW 310
gi 24652776   427 CEMFNEDDSPVGKAGHGMRKFFESRW 452
gi 22653668  1940 CETFNEDDSDIGRAGHNMRKYFEKKW 1965
gi 148922865  412 CEKFNEDNSDIGRAGHNMRKFFEKRW 437
gi 115698917 2212 CETFNEDESEVGRAGHAMRSFFETRW 2237
gi 158591872 1533 CRTFNEDESPIGQSGVTLHKFYLKRW 1558

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