Conserved Protein Domain Family
Bromo_brd8_like

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cd05507: Bromo_brd8_like 
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99939
View PSSM: cd05507
Aligned: 14 rows
Threshold Bit Score: 155.215
Threshold Setting Gi: 17534575
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #    #  #                                            
gi 110763449  793 YRAWKKAVMLVYNRLatHKYASVFLRPItedqAPGYHSVIFRPMDLSTIKKNIDNGt----------------------I 850
gi 53136534   782 QKIWKKAIMLVWRAAanHRYANVFLQPVtddiAPGYHSIVQRPMDLSTIKKNIENGl----------------------I 839
gi 34452707  1105 HLLFKKTLLPVWKMIasHRFSSPFLKPVserqAPGYKDVVKRPMDLTSLKRNLSKGr----------------------I 1162
gi 34784101   633 QKIWKKAIMLVWRAAanHRYASVFLQPVsddiAPGYHSIVHRPMDLSAIKKNIESGq----------------------I 690
gi 76155901   272 ARRWRRSLLSALSTVysHRHAYVFMHPVtediAPGYSTVVYEPVDLTSLRRRMESSlsylissqqpsalnpsissyqviV 351
gi 7301767    729 RAASKKLFLSIYAMLldSKHAAPFKRPFhdehAQRHADLCLRPMDFPTIKRNIDSGf----------------------I 786
gi 108880907  806 YRAWKKAILSILAKVssCRQAAAFLKPLp---DEQVSDIIYRPMDLSVIKKNVENGi----------------------I 860
gi 17534575   642 EDTTKLKLLAMYRYLhdCEWSEAFKKPVpl-gEATYDQGVLERIDLSLIKKEIDNGt----------------------I 698
gi 39596931   681 EAAMKANLMKRWDTIerHPCAEPFREPVpe-cEEEYGLGIHEKVDLSAIRRDIDTGv----------------------V 737
gi 116063320  584 QKIWKKAIMLVWRAAanHRYANVFLQPVtddiAPGYHSIVHRPMDLSTIKKNIETGl----------------------I 641
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
Feature 1                         #   #      #                   
gi 110763449  851 RSTMHFQRDVMLMFQNAIMYNKHd-TFIYKMAVSMQEECLQHMQILV 896
gi 53136534   840 RTTAEFQRDIMLMFQNAVMYNSSd-HDVYHMAVEMQRDVLEQIQQFL 885
gi 34452707  1163 RTMAQFLRDLMLMFQNAVMYNDSd-HHVYHMAVEMRREVLEQIQVLN 1208
gi 34784101   691 RTTAEFQRDIMLMFQNAVMYNSSd-HDVYHMALEMQRDVLEQIQQFL 736
gi 76155901   352 EVAARFIRDLLLMFMNARMYNSQn-HEVHRMAGEMYHDVISELQPLW 397
gi 7301767    787 RSLSELHRDVLLMAHNVLVAYKPhtAQHKTARLFVQDCQAIKEFSQL 833
gi 108880907  861 RSSSEFQRDVMLMYTNAMVLNRPd-LCCSKAANFLVTECIALMESIP 906
gi 17534575   699 NSESGFLLRAYRMLSNAIMYNGYd-HDVHLHAKYIIEHVMNDIHTLN 744
gi 39596931   738 DGLTLFLLRTYRMFSNAVMFNGYd-HDVALQAKDIHCSTMKLMVQEI 783
gi 116063320  642 RSTAEFQRDIMLMFQNAVMYNSSd-HDVYHMAVEMQRDVLEQIQQFL 687

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