Conserved Protein Domain Family
Bromo_RACK7

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cd05508: Bromo_RACK7 
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99940
View PSSM: cd05508
Aligned: 10 rows
Threshold Bit Score: 149.841
Threshold Setting Gi: 23172789
Created: 12-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #     #  #                                      #   #
gi 91092540   226 LEHLCNLLKFAVKrmiqcngSEPFIHPVde-kqFPEYRNYIVQPMTLTMLEKNIKdnaYGSTQAFESDAKWILHNSIIFN 304
gi 66911096   191 IEQLSYLLKFALQkmk-qpgTEPFQKPVsl-eqHPDYAEYIFYPMDLSTLEKNVKkkmYGCTEAFLAEAKWILHNCIIYN 268
gi 6329749    170 IEQLSYLLKFAIQkmk-qpgTDAFQKPVpl-eqHPDYAEYIFHPMDLCTLEKNAKkkmYGCTEAFLADAKWILHNCIIYN 247
gi 34784012   151 LEQLSYLLKFALQkmk-qpgTEPFQKPVsl-dqHPNYAEYIFHPMDLSTLEKNIKkkmYGCTEAFLADVKWILHNCIIYN 228
gi 66531166   156 VDQLCLLLKHVVErmreypgSEPFWKPVel-seAPNYLDYVVKPMDLSLLESNVRaklYGSTDAFMADAKWIQHNCIVFN 234
gi 108873960  357 QDSLTISLKFTMKrml-qlkGSAILNPLdk-ehFPNYDAYVTKHIDLTTLQKNVVeqkYQTTDAFQADVNWILHNASIYP 434
gi 23172789   403 VDLLSQLLSFALDrmkhvrgAHKLRSPLev--fPLTYKKFFVNPVSFESLAQCIRngaYQSTDEFLSEVKWIQHNALILD 480
gi 156363241   99 TDELSKMLKFTLErmk--ekAKDFLQPFcl-ekYDDYLQFVIKPVDLSLLEKNVRkkhYKTAKQFREHAQWILHNAIIYF 175
gi 118100625  259 TEQLSYLLKFALQkmk-qpgTEPFQKPVsl-dqHPDYAEYIFHPMDLCTLEKNVKkkmYGCTEAFLADAKWILHNCIIYN 336
gi 115640580  158 VDKLAKVLRTSIEkmk-rytNSLLFTPIddlreFRDYRQFVFHPMDLSVMEKNVQsrsYGSTEAFLADAKWIVHNAFVYF 236
                          90       100
                  ....*....|....*....|....*..
Feature 1                    #               
gi 91092540   305 Syq------skLTTAAKTIVKICKQEM 325
gi 66911096   269 Ggn------hkLTQTAKVIIKICEHEM 289
gi 6329749    248 Ggn------hkLTQIAKVVIKICEHEM 268
gi 34784012   229 Ggn------hkLTATAKVIVKICEHEM 249
gi 66531166   235 TcggvytdtskLTNAAKQIIKLARQEV 261
gi 108873960  435 Lns-------kLLSIAKGLMKICKQEI 454
gi 23172789   481 Agd------akVEQASKAVVKVCRQEA 501
gi 156363241  176 Ged------reLTELAEAIMEDCDGEL 196
gi 118100625  337 Ggn------hkLTQTAKVIIKICEHEM 357
gi 115640580  237 Gsg------nrYSNAAKALLKACETEM 257

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