Conserved Protein Domain Family
Bromo_gcn5_like

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cd05509: Bromo_gcn5_like 
Click on image for an interactive view with Cn3D
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99941
View PSSM: cd05509
Aligned: 52 rows
Threshold Bit Score: 138.842
Threshold Setting Gi: 3876449
Created: 12-Sep-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #    #  #                                      #   #   
1E6I_A         13 PHDAAIQNILTELQNHaAAWPFLQPVNKEeVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGEN 92
2RI7_A         72 KDYEGLKRVLRSLQAHkMAWPFLEPVDPNdAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSD 151
gi 47223942  2620 KDYEGLRRTLRSLQAHkMAWPFLEPVDTNdAPDYYRVIKEPMDLSTMEERLQRREYVKLTEFVADMTKIFDNCRYYNPSD 2699
gi 115683727 3352 KDYDHLKKMLRQLQSHkMAWPFLEPVSELdAADYYDVIKDPMDLSTVDDRLKNKHYVKLSDFAADIGKVFDNCRFYNPTD 3431
gi 156395131   51 RDHDSLKRMLRSLQSHkMAWPFLEPVSGLdVPGYYDVIKEPMDLSTVEDKITSKKYATLEQFVSDVTRIFDNCRFFNGKD 130
gi 23092682  2560 NDVEELKNLIKQMQLHkSAWPFMEPVDPKeAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMTKIFDNCRYYNPKE 2639
2F6J_A         72 KDYEGLKRVLRSLQAHkXAWPFLEPVDPNdAPDYYGVIKEPXDLATXEERVQRRYYEKLTEFVADXTKIFDNCRYYNPSD 151
2FSA_C         72 KDYEGLKRVLRSLQAHkXAWPFLEPVDPNdAPDYYGVIKEPXDLATXEERVQRRYYEKLTEFVADXTKIFDNCRYYNPSD 151
gi 158600017 2070 PDFDLLWHAFDSLKSHrTSWPFRQAVDQKnHPDYYSIIKKPMDLSIVQRKLEHYEYHSLKEFTTDIAQIFENARIFNSKD 2149
gi 3876449    350 ADYTHVFELLELLLEHrMSTPFRNPVDLNeFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVNQMFENAKTYNPKG 429
                          90       100
                  ....*....|....*....|.
Feature 1           #                  
1E6I_A         93 TSYYKYANRLEKFFNNKVKEI 113
2RI7_A        152 SPFYQCAEVLESFFVQKLKGF 172
gi 47223942  2700 SPFYQCAEVLENFFVQKLKCF 2720
gi 115683727 3432 TPYYQCADVLEKFFIQKMKAL 3452
gi 156395131  131 TPYYRCAEVLEAVFVQKLRAW 151
gi 23092682  2640 SSFYKCAEALESYFVQKIKNF 2660
2F6J_A        152 SPFYQCAEVLESFFVQKLKGF 172
2FSA_C        152 SPFYQCAEVLESFFVQKLKGF 172
gi 158600017 2150 SAIYQCADILEKQFRERIVKV 2170
gi 3876449    430 NAVFKCAETMQEVFDKKLIDV 450

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