Conserved Protein Domain Family
Bromo_brd1_like

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cd05512: Bromo_brd1_like 
Click on image for an interactive view with Cn3D
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99944
View PSSM: cd05512
Aligned: 10 rows
Threshold Bit Score: 186.451
Threshold Setting Gi: 91087827
Created: 12-Sep-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #    #  #                                      #   #   
2D9E_A          7 GFLILLRKTLEQLQekDTGNIFSEPVPLseVPDYLDHIKKPMDFFTMKQNLEayrYLNFDDFEEDFNLIVSNCLKYNAKD 86
gi 71895457   637 PFLILLRKTLEHLQekDTGNIFSEPVPLseVPDYLDHIKKPMDFQTMKQNLEayrYLNFDDFEEDFNLIINNCLKYNAKD 716
gi 6331389    602 PFNVLLRTTLDLLQekDPAHIFAEPVNLseVPDYLEFISKPMDFSTMRRKLEshlYRTLEEFEEDFNLIVTNCMKYNAKD 681
gi 49118426   565 PLTVLLRSLLEQLQekDPARIFAHPVNLseVPDYLDHIKHPMDFSTMKKRLEdqrYRNLNEFEEDFNLIIENCMKYNAKD 644
gi 7304241    615 PLEAALNKLLDALEarDSMQIFREPVDTseVPDYTDIVKQPMDLGTMRAKLKecqYNSLEQLEADFDLMIQNCLAYNNKD 694
gi 91087827   570 PLEASLRLVLDLVAakDTNEIFSEPVDLeeVPDYTTVVSEPMDLSTMRKKLDdglYPDLTSMEKDFDLMIANCLAYNNRD 649
gi 66513632   525 PLESILRSLLEAIKmkDINDVFGQPVNTkeVPDYLEIVSHPMDLSTMQTKIErqeYDTIGAFEADFNLMVNNCLAYNRKD 604
gi 156382583  604 PLNIVLRKTLDQVQtkDPGEIFSDPVDTneVLDYLDVIKQPMDFSTMRSRIDsnfYHTIEQFEADFNLIIENCMAYNAQD 683
gi 56208593   548 PFTVILRAVLDQLQekDQAHIFAEPVNIkeVPDYMDHVLHPMDFSTMSKRIEaqgYKYLDEFEADFNLITDNCMKYNGKD 627
gi 47206036   583 PMLVLLRSTLEQLQekDTALIFAQPVDIkeVPDYAEFISQPMDFSTMQSKLEshaYRSVGDLEDDFNLMISNCLLYNTKD 662
                          90
                  ....*....|....*...
Feature 1           #               
2D9E_A         87 TIFYRAAVRLREQGGAVL 104
gi 71895457   717 TIFYRAAVRLREQGGVVL 734
gi 6331389    682 TIFHRAAVRLRDLGGAIL 699
gi 49118426   645 TIFYRAAVRLRDHGGVLL 662
gi 7304241    695 TVFYRAGIRMRDQAAPLF 712
gi 91087827   650 TVFYRAAIKMRDQCGAIF 667
gi 66513632   605 TMFYRAGIKMKEQGGILI 622
gi 156382583  684 TIYYRAALKLRDQGRPII 701
gi 56208593   628 TFFYRAAVKLRDQGGAIL 645
gi 47206036   663 TVYHRTALRLRELGGAVL 680

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