Conserved Protein Domain Family
Bromo_brd7_like

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cd05513: Bromo_brd7_like 
Click on image for an interactive view with Cn3D
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99945
View PSSM: cd05513
Aligned: 10 rows
Threshold Bit Score: 173.75
Threshold Setting Gi: 66811704
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #    #  #                                      #   #   
2I7K_A          8 PLQEALNQLMRQLQRkDPSAFFSFPVtDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPE 87
gi 53130979   135 PLQEALNQLMRQLQRkDPSSFFSFPVtDFIAPGYSMIIKNPMDFSTMKEKIKNNGYQSIEELKDNFKLMCTNAMTYNKPD 214
gi 41350212   135 PLQEALNQLMRQLQRkDPSAFFSFPVtDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPE 214
gi 47124770   138 PLQEALNQLVRQLQRkDPGAFFSFPVtDFIAPGYSLIIKNPMDFSTMKEKIRNCEYRSIEEFKENFKQICHNAMIYNKPG 217
gi 33416407   129 PLQEALSQLIRQLQRkDPSAFFSFPVtDLIAPGYSIIIKKPMDFSTIKEKVKKEQYQSLEELKLDFRVMCENAMIYNKPE 208
gi 7297294    279 PLNKLLEHLLRFLEKrDPHQFFAWPVtDDMAPGYSSIISRPMDFSTMRQKIDDHEYTALTEFTDDFKLMCENAIKYNHVD 358
gi 72114827   159 PILKVLENLQKTLQRkDVDGFFAWPVnDIIAPGYSSIILQPMDFCTMKKKIEREDYNSIDEYKDDFVTMCENAMKYNRPE 238
gi 156398114  160 ALQLCLENLHITLQRkDIQGFFAYPVnDAIAPGYSRVITHPMDFSTIKTKIDSNSYTTIEAFRDDFYLMCNNAMVYNAPD 239
gi 66811704   265 HYKKIFGQIIQLLMKkDTHGFFYSPVtEQIAPNYFKYIREPMDFETMLKKNKEFRYLNIDKFQYDFTLICENCMKYNDSA 344
gi 91085319   149 PVQRMLDQLLGLLEKkDPQQFFAWPVtDNIAPGYSSIITQPMDFSTMRQKIEDNQYDNLQDFNADFKLMCTNAMKYNHVD 228
                          90
                  ....*....|....*...
Feature 1           #               
2I7K_A         88 TIYYKAAKKLLHSGMKIL 105
gi 53130979   215 TIYYKAAKKLLHSGMKIL 232
gi 41350212   215 TIYYKAAKKLLHSGMKIL 232
gi 47124770   218 TIYYRAAKKLLNSGIKIL 235
gi 33416407   209 TIYYKAAKKLLHSGMKIL 226
gi 7297294    359 TVYNKAAKRLLQVGMKHL 376
gi 72114827   239 TVYYKAAKKLLGTGLKVM 256
gi 156398114  240 TIYFKAAKRIMQIGAKMM 257
gi 66811704   345 SVYYKEAKRLLTNGRSII 362
gi 91085319   229 TIYYKASKKLLHAGSKMM 246

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